Designing a template bank to observe compact binary coalescences in Advanced LIGO's second observing run

We describe the methodology and novel techniques used to construct a set of waveforms, or template bank, applicable to searches for compact binary coalescences in Advanced LIGO's second observing run. This template bank is suitable for observing systems composed of two neutron stars, two black holes, or a neutron star and a black hole. The Post-Newtonian formulation is used to model waveforms with total mass less than 4 $M_{\odot}$ and the most recent effective-one-body model, calibrated to numerical relativity to include the merger and ringdown, is used for total masses greater than 4 $M_{\odot}$. The effects of spin precession, matter, orbital eccentricity and radiation modes beyond the quadrupole are neglected. In contrast to the template bank used to search for compact binary mergers in Advanced LIGO's first observing run, here we are including binary-black-hole systems with total mass up to several hundreds of solar masses, thereby improving the ability to observe such systems. We introduce a technique to vary the starting frequency of waveform filters so that our bank can simultaneously contain binary-neutron-star and high-mass binary-black hole waveforms. We also introduce a lower-bound on the filter waveform length, to exclude very short-duration, high-mass templates whose sensitivity is strongly reduced by the characteristics and performance of the interferometers

Costimulatory blockade: A novel approach to the treatment of glomerular disease?

Costimulatory pathways (Cluster of differentiation 28, tumor necrosis factor-related, adhesion and T Cell Ig- and mucin-domain molecules) regulating the interactions between receptors on the T cells and their ligands expressed on several cell types, have a key role in controlling many immunological and non immunological processes. Indeed, accumulating evidence indicate that these molecules are involved in the pathogenesis of numerous conditions, such as allograft rejection, atherosclerosis, rheumatoid arthritis, psoriasis and renal diseases, including glomerulonephritis. Primary or secondary (i.e., associated with infections, drugs or systemic diseases, such as systemic lupus erythematosus, diabetes, etc.) glomerulonephritis represent a group of heterogeneous diseases with different pathogenic mechanisms. Since costimulatory molecules, in particular CD80 and CD40, have been found to be expressed on podocytes in the course of different experimental and clinical glomerulonephritis, costimulation has been thought as a new therapeutic target for patients with glomerular diseases. However, although experimental data suggested that the blockade of costimulatory pathways is effective and safe in the prevention and treatment of glomerular diseases, clinical trials reported contrasting results. So, at this moment, there is not a strong evidence for the general use of costimulatory blockade as an alternative treatment strategy in patients with primary or secondary glomerulonephritis. Here, we critically discuss the current data and the main issues regarding the development of this innovative therapeutic approach

A stochastic template bank for gravitational wave searches for precessing neutron star - black hole coalescence events

Gravitational wave searches to date have largely focused on non-precessing systems. Including precession effects greatly increases the number of templates to be searched over. This leads to a corresponding increase in the computational cost and can increase the false alarm rate of a realistic search. On the other hand, there might be astrophysical systems that are entirely missed by non-precessing searches. In this paper we consider the problem of constructing a template bank using stochastic methods for neutron star - black hole binaries allowing for generic precession, but with the restriction that the total angular momentum of the binary is pointing towards the detector. We quantify the number of templates required for the search, and we explicitly construct the template bank. We show that despite the large number of templates, stochastic methods can be adapted to solve the problem. We quantify the parameter space region over which the non-precessing search might miss signals

Renal involvement in mushroom poisoning: The case of Orellanus syndrome

none8Although mushroom poisoning is a rare cause of acute renal injury, in some cases it may lead to the development of a severe and irreversible renal failure. Orellanus syndrome is the most important example of organic renal damage related to mushroom consumption. It is caused by the ingestion of orellanine, the main toxin of different types of Cortinarius mushrooms (Cortinarius speciosissimus, C. orellanus, C. orellanoides, etc.), and it is characterized by progressive clinical phases with a predominant kidney involvement, finally requiring renal replacement therapy in about 10% of cases. Renal damage is often late and associated with a histological picture of interstitial nephritis. Diagnosis is essentially clinical and no specific therapy has been shown to be effective in preventing and treating renal damage. Here, we describe the case of a patient with mixed wild mushroom poisoning, presenting the typical clinical signs and course of the Orellanus syndrome. This case offers us the opportunity to review the main clinical features of this severe and little-known intoxication.openEsposito, P; La Porta, E; Calatroni, M; Bianzina, S; Libetta, C; Gregorini, M; Rampino, T; Dal Canton, AEsposito, P; La Porta, E; Calatroni, M; Bianzina, S; Libetta, Carmelo; Gregorini, Marilena; Rampino, Teresa; DAL CANTON, Antoni

Management of mineral metabolism in hemodialysis patients: discrepancy between interventions and perceived causes of failure

none8BACKGROUND: Mineral and bone disorders (MBD) in patients undergoing hemodialysis (HD) are a major clinical complication. Current therapeutic strategies do not attain the expected results. The Italian audit on mineral metabolism was implemented to investigate MBD management through a "patient-oriented" approach. METHODS: Clinical and laboratory data pertinent to MBD from 509 prevalent adult patients on chronic HD were recorded and examined (audit), after which individual strategies were elaborated to improve MBD control. Their effectiveness was evaluated 6 months after the audit (Post-6). RESULTS: The audit disclosed poor MBD control in a high percentage of patients (56 %). Low compliance to treatment was the major determinant of failure (in 43.5 % of cases). Logistic regression showed a direct correlation between high degree of compliance and the achievement of therapeutic targets, e.g. parathyroid hormone: odds ratio (OR) 2.48, p = 0.015. In contrast, a minority of the proposed interventions (14.7 %) included strategies to improve patient compliance. At Post-6, despite a significant increase in drug prescription (p < 0.05 vs. audit), the rate of successful MBD control was unchanged. CONCLUSIONS: Low compliance with treatment is a major, but still neglected, cause of failure in the achievement of MBD control in HD patients.Esposito, P; Rampino, T; Gregorini, M; Tinelli, C; De Silvestri, A; Malberti, F; Coppo, R; Dal Canton, A.Esposito, P; Rampino, Teresa; Gregorini, Marilena; Tinelli, C; De Silvestri, A; Malberti, F; Coppo, R; DAL CANTON, Antoni

An improved pipeline to search for gravitational waves from compact binary coalescence

The second generation of ground-based gravitational-wave detectors will begin taking data in September 2015. Sensitive and computationally-efficient data analysis methods will be required to maximize what we learn from their observations. We describe improvements made to the offline analysis pipeline searching for gravitational waves from stellar-mass compact binary coalescences, and assess how these improvements affect search sensitivity. Starting with the two-stage ihope pipeline used in S5, S6 and VSR1-3 and using two weeks of S6/VSR3 data as test periods, we first demonstrate a pipeline with a simpler workflow. This single-stage pipeline performs matched filtering and coincidence testing only once. This simplification allows us to reach much lower false-alarm rates for loud candidate events. We then describe an optimized chi-squared test which minimizes computational cost. Next, we compare methods of generating template banks, demonstrating that a fixed bank may be used for extended stretches of time. Fixing the bank reduces the cost and complexity, compared to the previous method of regenerating a template bank every 2048 s of analyzed data. Creating a fixed bank shared by all detectors also allows us to apply a more stringent coincidence test, whose performance we quantify. With these improvements, we find a 10% increase in sensitive volume with a negligible change in computational cost