A Defected Ground Structure without Ground Contact Problem and Application to Branch Line Couplers

A new defected ground structure (DGS) microstrip line that is free from the ground contact problem is described together with its application example. The proposed DGS microstrip line adopts a double-layered substrate. The first layer contains the microstrip line and DGS patterns on the top and bottom planes as with the conventional DGS line. The second substrate, of which upper metal plane has already been removed, is attached to the bottom ground plane of the first layer. This structure prevents the ground plane of the first substrate with DGS patterns from making contact with the metal housing. The proposed DGS microstrip line has advantageous transmission and rejection characteristics, without the ground contact problem of DGS patterns, which has been a critical problem of previous DGS lines. A 10 dB branch line hybrid coupler is designed and measured, as an example of application of the proposed DGS microstrip line

Flexible Microwave Tag System Based on DGS Multiple Resonators

A new flexible microwave tag system using a frequency-scanning type RFID is proposed with multiple resonators based on defected ground structures (DGSs). The proposed system achieves fully passive tag systems using multiple resonators with a spiral-shaped DGS over a wide frequency range. The resonator implemented on the rear side of a transmission line has the advantages of excellent band notch characteristics as well as bit-error avoidance from the frequency selective reflection. In addition, the tag system is designed on a thin flexible substrate in order to be applicable for amorphous surfaces. The proposed microwave tags have been implemented with wideband antennas at 3–7 GHz on thick and thin flexible substrates. The flexibility of the thin substrate has been evaluated in terms of cognitive capability for various radiuses of curvatures. From the experimental results in an anechoic chamber, the excellent recognition of various multibits identification codes in a wireless transmission environment has been verified

A Wideband Doherty Combiner with Phase Variation Compensation Using LTCC Applicable for High Power Transmission

In this paper, we propose a small-sized Doherty combiner with phase variation compensation using low temperature co-fired ceramic (LTCC) substrate. The proposed design theory for the Doherty combiner is derived using the phase calculation of the S-parameter based on the relation between the input and output ports. The proposed circuit is designed after determining the band edge frequency and the targeted degree of the phase balance. The proposed circuit is verified using the microstrip line and the LTCC substrate. The implemented structure, using LTCC as the substrate, is operated under a high-power test of continuous wave 50 W, the results of which also show that the amplitude and phase balance have variations within 0.2 dB and ±1°, respectively. The high-power test shows that the implemented structure is applicable for high power Doherty amplifiers or combiners

A New Doherty Combiner with Wide Bandwidth for Magnitude and Phase Balance Compensation

This paper proposes a novel Doherty combiner that uses a series and parallel resonant circuit for wideband. Unlike conventional combiners, the aim of the proposed combiners is to extend bandwidth for not only the magnitude bandwidth, but also phase balance by employing series and parallel resonant circuits at the output impedance of the peaking amplifier. Considering the load impedance of the peaking amplifier, the Doherty combiners were analyzed in the theory of this study by deriving the series and parallel resonant circuit values. The output phase balances are determined for the targeted bandwidth to achieve uniform phase balance in the proposed combiner I using a series resonator. For better magnitude bandwidth, the slope of reflection coefficient (Γ) at port 3 in the combiner II using series resonator was derived using the derivative of Γ with respect to ω. Experimental results show that the proposed combiner I has 63.5% magnitude fractional bandwidth (FBW) and 118% FBW with the phase balance at ±2.5°. The proposed combiner II also has 85% magnitude FBW and 118% FBW with the phase balance at ±2.5°

Foods contributing to nutrients intake and assessment of nutritional status in pre-dialysis patients: a cross-sectional study

Abstract Background For chronic kidney disease (CKD) patients, management of nutritional status is critical for delaying progression to end-stage renal disease. The purpose of this study is to provide the basis for personalized nutritional intervention in pre-dialysis patients by comparing the foods contributing to nutrients intake, nutritional status and potential dietary inflammation of CKD patients according to the diabetes mellitus (DM) comorbidity and CKD stage. Methods Two hundred fifty-six outpatients referred to the Department of Nephrology at SNUH from Feb 2016 to Jan 2017 were included. Subjects on dialysis and those who had undergone kidney transplantation were excluded. Bioelectrical impedance analysis (BIA), subjective global assessment (SGA), dietary intake, and biochemical parameters were collected. Subjects were classified into 4 groups according to DM comorbidity (DM or Non-DM) and CKD stage (Early or Late) by kidney function. Two-way analysis of variance and multinomial logistic regression analysis were performed for statistical analysis. Results Total number of malnourished patients was 31 (12.1%), and all of them were moderately malnourished according to SGA. The body mass index (BMI) of the DM-CKD group was significantly higher than the Non-DM-CKD group. The contribution of whole grains and legumes to protein intake in the DM-CKD group was greater than that in the Non-DM-CKD group. The DM- Early-CKD group consumed more whole grains and legumes compared with the Non-DM-Early-CKD group. The subjects in the lowest tertile for protein intake had lower phase angle, SGA score and serum albumin levels than those in the highest tertile. The potential for diet-induced inflammation did not differ among the groups. Conclusions Significant differences in intakes of whole grains and legumes between CKD patients with or without DM were observed. Since contribution of whole grains and legumes to phosphorus and potassium intake were significant, advice regarding whole grains and legumes may be needed in DM-CKD patients if phosphorus and potassium intake levels should be controlled. The nutritional status determined by BIA, SGA and serum albumin was found to be different depending on the protein intake. Understanding the characteristics of food sources can provide a basis for individualized nutritional intervention for CKD patients depending on the presence of diabetes

Prenatally Detected Congenital Perineal Mass Using 3D Ultrasound which was Diagnosed as Lipoblastoma Combined with Anorectal Malformation: Case Report

We report a case of prenatally diagnosed congenital perineal mass which was combined with anorectal malformation. The mass was successfully treated with posterior sagittal anorectoplasty postnatally. On ultrasound examination at a gestational age of 23 weeks the fetal perineal mass were found on the right side. Any other defects were not visible on ultrasonography during whole gestation. Amniocentesis was performed to evaluate the fetal karyotyping and acetylcholinesterase which were also normal. As the fetus grew up, the mass size was slowly increased more and more. At birth, a female neonate had a perineal mass on the right side as expected. During operation, the anal sphincteric displacement was found near the mass and reconstructed through posterior sagittal incision. This is the first reported case of prenatally diagnosed congenital perineal mass, after birth which was diagnosed as lipoblastoma and even combined with anorectal malformation. This case shows that it can be of clinical importance to be aware of this rare fetal perineal mass in prenatal diagnosis and counseling

Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia

The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, which antagonizes B cell receptor (BCR) signals, demonstrates remarkable clinical activity in chronic lymphocytic leukemia (CLL). The lymphocytosis experienced by most patients under ibrutinib has previously been attributed to inhibition of BTK-dependent integrin and chemokine cues operating to retain the tumor cells in nodal compartments. Here, we show that the VLA-4 integrin, as expressed by CD49d-positive CLL, can be inside-out activated upon BCR triggering, thus reinforcing the adhesive capacities of CLL cells. In vitro and in vivo ibrutinib treatment, although reducing the constitutive VLA-4 activation and cell adhesion, can be overcome by exogenous BCR triggering in a BTK-independent manner involving PI3K. Clinically, in three independent ibrutinib-treated CLL cohorts, CD49d expression identifies cases with reduced lymphocytosis and inferior nodal response and behaves as independent predictor of shorter progression-free survival, suggesting the retention of CD49d-expressing CLL cells in tissue sites via activated VLA-4. Evaluation of CD49d expression should be incorporated in the characterization of CLL undergoing therapy with BCR inhibitors