How WEIRD is Usable Privacy and Security Research? (Extended Version)

In human factor fields such as human-computer interaction (HCI) and psychology, researchers have been concerned that participants mostly come from WEIRD (Western, Educated, Industrialized, Rich, and Democratic) countries. This WEIRD skew may hinder understanding of diverse populations and their cultural differences. The usable privacy and security (UPS) field has inherited many research methodologies from research on human factor fields. We conducted a literature review to understand the extent to which participant samples in UPS papers were from WEIRD countries and the characteristics of the methodologies and research topics in each user study recruiting Western or non-Western participants. We found that the skew toward WEIRD countries in UPS is greater than that in HCI. Geographic and linguistic barriers in the study methods and recruitment methods may cause researchers to conduct user studies locally. In addition, many papers did not report participant demographics, which could hinder the replication of the reported studies, leading to low reproducibility. To improve geographic diversity, we provide the suggestions including facilitate replication studies, address geographic and linguistic issues of study/recruitment methods, and facilitate research on the topics for non-WEIRD populations.Comment: This paper is the extended version of the paper presented at USENIX SECURITY 202

A study on psychological training of eSports using digital games: Focusing on rhythm game

Incidentally, several studies have mentioned that digital games or video games have a positive impact on psychological skills (Green, et al., 2003; Pessoa, 2009; Anguera, et al., 2013). Thus, this study aimed to examine the psychological skills focusing on selective attention by comparing the power change in the beta wave band of the EEG during game play and the results of the trail making test (TMT) conducted before and after. Participants were ten male college students who usually play game for at least one hour per day, five days per week (age: M = 21.90 ± 1.96). This study adopted “Osu!” that is a free online rhythm game as an experimental task, because several articles mentioned that professional gamers usually use "Osu!" as a warming up or practice before gaming (Webb, 2019; Carpenter, 2019). Thus, “Osu!” is assumed to have the effect of enhancing the players’ psychological skills. In addition, the TMT part B is adopted to measure attention to speed, motor speed, visual screening, mental flexibility, perseverance, interference affinity and reaction inhibition. As a result of comparing change in biological attention extracted from the EEG during game play or baseline measurement, there is a significant difference in selective attentional state between baseline and while game play. In comparison of TMT indicated that processing speed in after rhythm game was tended to be faster than before play. Thus, this study might be indicated that rhythm game would be the one of the psychological or cognitive training tool for eSports

Examining effectiveness of e-sports activity in Japan

Digital games or video games have a positive impact on cognitive function. However, there is no study examining the positive effects of e-sports in Japan. Thus, we conducted two studies. Study 1 examined the relationship between e-sports and cognitive function using the Stroop and reverse-Stroop Color and Word Test. Additionally, study 2 examined the psychological statement while playing e-sports using biological evaluation. Study 1 included six male collegiate students who could play e-sports (three in the e-sports group, three in the control group), while study 2 involved two male Japanese collegiate e-sports players. The e-sports group played e-sports for 10 minutes and their cognitive function and psychological statement were evaluated during play. EEG was employed to evaluate the psychological statement of the e-sport players in study 2. Emotional condition (concentration) was analysed from the combination of the extracted raw EEG data using KANSEI Module Logger. Results of study 1 indicated that 10 minutes of e-sports activity significantly improved cognitive function, especially interference and concentration, in the e-sports group. Study 2 concluded that the average concentration value at play time was significantly higher than that during the resting period. Therefore, this study indicated that e-sports activity might have positive effects when played for a brief time

Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy

To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine

Effectiveness of motivational videos for elite swimmers: Subjective and biological evaluations

Motivational videos (MVs) are used in Japan in many competitive sports, both professional and amateur. However, several researchers have stated that the effectiveness of MVs has not been scientifically verified, and only subjective evaluations have been conducted in previous studies (Yamazaki & Sugiyama, 2009). This study examined the psychological effectiveness of MVs using both subjective and biological evaluations. The subjects were six elite Japanese collegiate swimmers participating in the FINA Swimming World Cup (age: 21.33 ± 0.51, four males and two females). We employed subjective and biological evaluations to examine these elite swimmers’ psychological motivation while watching an MV as part of their practice. We adopted subjective and self-report Psychological Condition Inventory (Yamazaki et al., 2008) to measure the athletes’ level of vigor while watching the MV. An electroencephalogram (EEG) was employed to evaluate the emotions of the swimmers. The emotional condition (vigor) was analysed by combining the extracted raw EEG data using a KANSEI module logger (Littlesoftware, 2018). A subjective evaluation showed that the score for vigor significantly improved after watching the MV (t = 2.33, p < 0.05), which was also indicated by the results of the biological evaluation (t = 5.69, p < 0.01). There was also a significant correlation between subjective and biological vigor after watching the MV (r = 0.77, p < 0.01). The results of this study, therefore, indicated that biological evaluation can be employed anew to verify the effectiveness of MVs

Fibroblasts Show More Potential as Target Cells than Keratinocytes in COL7A1 Gene Therapy of Dystrophic Epidermolysis Bullosa

Dystrophic epidermolysis bullosa (DEB) is an inherited blistering skin disorder caused by mutations in the type VII collagen gene (COL7A1). Therapeutic introduction of COL7A1 into skin cells holds significant promise for the treatment of DEB. The purpose of this study was to establish an efficient retroviral transfer method for COL7A1 into DEB epidermal keratinocytes and dermal fibroblasts, and to determine which gene-transferred cells can most efficiently express collagen VII in the skin. We demonstrated that gene transfer using a combination of G protein of vesicular stomatitis virus-pseudotyped retroviral vector and retronectin introduced COL7A1 into keratinocytes and fibroblasts from a DEB patient with the lack of COL7A1 expression. Real-time polymerase chain reaction analysis of the normal human skin demonstrated that the quantity of COL7A1 expression in the epidermis was significantly higher than that in the dermis. Subsequently, we have produced skin grafts with the gene-transferred or untreated DEB keratinocytes and fibroblasts, and have transplanted them into nude rats. Interestingly, the series of skin graft experiments showed that the gene-transferred fibroblasts supplied higher amount of collagen VII to the new dermal–epidermal junction than the gene-transferred keratinocytes. An ultrastructural study revealed that collagen VII from gene-transferred cells formed proper anchoring fibrils. These results suggest that fibroblasts may be a better gene therapy target of DEB treatment than keratinocytes

Improvement of the SOD activity of the Cu2+ complexes by hybridization with lysozyme and its hydrogen bond effect on the activity enhancement

We prepared L-amino acids (L-valine and L-serine, respectively) based on the Schiff base Cu2+ complexes CuSV and CuSS in the absence/presence of hydroxyl groups and their imidazole-bound compounds CuSV-Imi and CuSS-Imi to reveal the effects of hydroxyl groups on SOD activity. The structural and spectroscopic features of the Cu2+ complexes were evaluated using X-ray crystallography, UV-vis spectroscopy, and EPR spectroscopy. The spectroscopic behavior upon addition of lysozyme indicated that both CuSV and CuSS were coordinated by the imidazole group of His15 in lysozyme at their equatorial position, leading to the formation of hybrid proteins with lysozyme. CuSS-Imi showed a higher SOD activity than CuSV-Imi, indicating that the hydroxyl group of CuSS-Imi played an important role in the disproportionation of O2− ion. Hybridization of the Cu2+ complexes CuSV and CuSS with lysozyme resulted in higher SOD activity than that of CuSV-Imi and CuSS-Imi. The improvements in SOD activity suggest that there are cooperative effects between Cu2+ complexes and lysozyme