9,325 research outputs found

    Fusion of neurohypophyseal membranes in vitro

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    Freeze cleaving electron microscopy has shown that fusion of isolated secretory vesicles from bovine neurohypophyses was induced by Ca 2+ in micromolar concentrations. Mg 2+ and Sr 2+ were ineffective. Mg 2+ inhibited Ca 2+-induced fusion. In suspensions containing secretory vesicles as well as sheets of cell membrane, release of vasopressin parallel to intervesicular fusion of secretory vesicles with sheets of cell membrane was observed after exposure to Ca 2+. Mg 2+ and Sr 2+ were ineffective in replacing Ca 2+ as trigger for fusion or vasopressin release. Intervesicular fusion and exocytotic profiles were observed when isolated neurohypophyses or neurosecretosome were exposed to cold

    Generation of High-Energy Photons with Large Orbital Angular Momentum by Compton Backscattering

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    Usually, photons are described by plane waves with a definite 4-momentum. In addition to plane-wave photons, "twisted photons" have recently entered the field of modern laser optics; these are coherent superpositions of plane waves with a defined projection hbar*m of the orbital angular momentum onto the propagation axis, where m is integer. In this paper, we show that it is possible to produce high-energy twisted photons by Compton backscattering of twisted laser photons off ultra-relativistic electrons. Such photons may be of interest for experiments related to the excitation and disintegration of atoms and nuclei, and for studying the photo-effect and pair production off nuclei in previously unexplored experimental regimes.Comment: 4 pages; RevTe

    Nuclear recoil energy scale in liquid xenon with application to the direct detection of dark matter

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    We show for the first time that the quenching of electronic excitation from nuclear recoils in liquid xenon is well-described by Lindhard theory, if the nuclear recoil energy is reconstructed using the combined (scintillation and ionization) energy scale proposed by Shutt {\it et al.}. We argue for the adoption of this perspective in favor of the existing preference for reconstructing nuclear recoil energy solely from primary scintillation. We show that signal partitioning into scintillation and ionization is well-described by the Thomas-Imel box model. We discuss the implications for liquid xenon detectors aimed at the direct detection of dark matter

    Effect of nasal inflammation and of intranasal anti-inflammatory treatment on bronchial asthma

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    AbstractIt is logical to look upon the nose and the bronchi as integrated parts of one ‘united airway’ and we would like to advance the hypothesis that optimal management of airway disease, caused by inhaled allergens, may necessitate control of inflammation in all parts of the airways. Nasal inflammation can aggravate asthma symptoms, and there is a rationale for giving intranasal anti-inflammatory treatment to patients with asthma. (i) Inhaled allergens are predominantly deposited in the nose, whether a patient suffers from rhinitis, asthma or both. (ii) Antigen presentation consequently takes place in the nose, and the response of the airway immune system is thus initiated in the nasal mucous membrane. (iii) Antigen presentation in the nose may possibly induce cell recruitment and activation not only in the nasal mucosa but also in the lower airways. (iv) Suppression of nasal inflammation may therefore be necessary for optimal management of asthma

    Response of the large-scale subglacial drainage system of Northeast Greenland to surface elevation changes

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    The influence of subglacial water on the dynamics of ice flow has been the object of increasing interest in the past decade. In this study we focus on large-scale, long-term changes in surface elevation over Northeast Greenland and the corresponding changes in subglacial water routeways. Our results show that over timescales ranging from decades to millennia the area may experience redistribution of and fluctuation in subglacial water outflux under the main glacier outlets. The fluctuations in subglacial water routing occur even in the absence of external forcing. Based on these results we conclude that changes in the subglacial water routeways are an intrinsic part of the drainage basin dynamics, where the subglacial system is likely always in a transient state. The results also imply that fluctuations at the margins observed at present might originate from changes several hundred kilometres upstream. Since surface elevation changes may propagate upstream over timescales much longer than the observational period, the cause of the fluctuations may not be present in current observational records

    Cluster Analysis of Thermal Icequakes Using the Seismometer to Investigate Ice and Ocean Structure (SIIOS): Implications for Ocean World Seismology

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    Ocean Worlds are of high interest to the planetary community due to the potential habitability of their subsurface oceans. Over the next few decades several missions will be sent to ocean worlds including the Europa Clipper, Dragonfly, and possibly a Europa lander. The Dragonfly and Europa lander missions will carry seismic payloads tasked with detecting and locating seismic sources. The Seismometer to Investigate Ice and Ocean Structure (SIIOS) is a NASA PSTAR funded project that investigates ocean world seismology using terrestrial analogs. The goals of the SIIOS experiment include quantitatively comparing flight-candidate seismometers to traditional instruments, comparing single-station approaches to a small-aperture array, and characterizing the local seismic environment of our field sites. Here we present an analysis of detected local events at our field sites at Gulkana Glacier in Alaska and in Northwest Greenland approximately 80 km North of Qaanaaq, Greenland. Both field sites passively recorded data for about two weeks. We deployed our experiment on Gulkana Glacier in September 2017 and in Greenland in June 2018. At Gulkana there was a nearby USGS weather station which recorded wind data. Temperature data was collected using the MERRA satellite. In Greenland we deployed our own weather station to collect temperature and wind data. Gulkana represents a noisier and more active environment. Temperatures fluctuated around 0C, allowing for surface runoff to occur during the day. The glacier had several moulins, and during deployment we heard several rockfalls from nearby mountains. In addition to the local environment, Gulkana is located close to an active plate boundary (relative to Greenland). This meant that there were more regional events recorded over two weeks, than in Greenland. Greenlands local environment was also quieter, and less active. Temperatures remained below freezing. The Greenland ice was much thicker than Gulkana (~850 m versus ~100 m) and our stations were above a subglacial lake. Both conditions can reduce event detections from basal motion. Lastly, we encased our Greenland array in an aluminum vault and buried it beneath the surface unlike our array in Gulkana where the instruments were at the surface and covered with plastic bins. The vault further insulated the array from thermal and atmospheric events

    Ultrasound in Abdominal Aortic Aneurysm

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