927 research outputs found
Classes of Measures Generated by Capacities
We introduce classes of measures in the half-space
generated by Riesz, or Bessel, or Besov capacities in , and give
a geometric characterization as Carleson-type measures
Performance of the Micromegas detector in the CAST experiment
The gaseous Micromegas detector designed for the CERN Axion search experiment
CAST, operated smoothly during Phase-I, which included the 2003 and 2004
running periods. It exhibited linear response in the energy range of interest
(1-10keV), good spatial sensitivity and energy resolution (15-19% FWHM at
5.9keV)as well as remarkable stability. The detector's upgrade for the 2004
run, supported by the development of advanced offline analysis tools, improved
the background rejection capability, leading to an average rate 5x10^-5
counts/sec/cm^2/keV with 94% cut efficiency. Also, the origin of the detected
background was studied with a Monte Carlo simulation, using the GEANT4 package.Comment: Prepared for PSD7: The Seventh International Conference on Position
Sensitive Detectors, Liverpool, United Kingdom, 12-16 Sep. 200
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Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study
Background
Modifying dairy fat composition by increasing the MUFA content is a potential strategy to reduce dietary SFA intake for cardiovascular disease (CVD) prevention in the population.
Objectives
To determine the effects of consuming SFA-reduced, MUFA-enriched (modified) dairy products, compared with conventional dairy products (control), on the fasting cholesterol profile (primary outcome), endothelial function assessed by flow-mediated dilatation (FMD; key secondary outcome), and other cardiometabolic risk markers.
Methods
A double-blind, randomized, controlled crossover 12-wk intervention was conducted. Participants with a 1.5-fold higher (moderate) CVD risk than the population mean replaced habitual dairy products with study products (milk, cheese, and butter) to achieve a high-fat, high-dairy isoenergetic daily dietary exchange [38% of total energy intake (%TE) from fat: control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA) diet].
Results
Fifty-four participants (57.4% men; mean ± SEM age: 52 ± 3 y; BMI: 25.8 ± 0.5 kg/m2) completed the study. The modified diet attenuated the rise in fasting LDL cholesterol observed with the control diet (0.03 ± 0.06 mmol/L and 0.19 ± 0.05 mmol/L, respectively; P = 0.03). Relative to baseline, the %FMD response increased after the modified diet (0.35% ± 0.15%), whereas a decrease was observed after the control diet (−0.51% ± 0.15%; P< 0.0001). In addition, fasting plasma nitrite concentrations increased after the modified diet, yet decreased after the control diet (0.02 ± 0.01 μmol/L and −0.03 ± 0.02 μmol/L, respectively; P = 0.01).
Conclusions
In adults at moderate CVD risk, consumption of a high-fat diet containing SFA-reduced, MUFA-enriched dairy products for 12 wk showed beneficial effects on fasting LDL cholesterol and endothelial function compared with conventional dairy products. Our findings indicate that fatty acid modification of dairy products may have potential as a public health strategy aimed at CVD risk reduction. This trial was registered at clinicaltrials.gov as NCT02089035
Energy resolution of alpha particles in a microbulk Micromegas detector at high pressure Argon and Xenon mixtures
The latest Micromesh Gas Amplification Structures (Micromegas) are achieving
outstanding energy resolution for low energy photons, with values as low as 11%
FWHM for the 5.9 keV line of Fe in argon/isobutane mixtures at
atmospheric pressure. At higher energies (MeV scale), these measurements are
more complicated due to the difficulty in confining the events in the chamber,
although there is no fundamental reason why resolutions of 1% FWHM or below
could not be reached. There is much motivation to demonstrate experimentally
this fact in Xe mixtures due to the possible application of Micromegas readouts
to the Double Beta Decay search of Xe, or in other experiments needing
calorimetry and topology in the same detector. In this paper, we report on
systematic measurements of energy resolution with state-of-the-art Micromegas
using a 5.5 MeV alpha source in high pressure Ar/isobutane mixtures. Values as
low as 1.8% FWHM have been obtained, with possible evidence that better
resolutions are achievable. Similar measurements in Xe, of which a preliminary
result is also shown here, are under progress.Comment: 16 pages, 19 figures, version after referees comments. Accepted for
publication in Nuclear Instruments and Methods
AKT regulates NPM dependent ARF localization and p53mut stability in tumors
Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive. Here we describe how NPM and ARF associate in the nucleoplasm to form a MDM2 inhibitory complex. We find that oligomerization of NPM drives nucleolar accumulation of ARF. Moreover, the formation of NPM and ARF oligomers antagonizes MDM2 association with the inhibitory complex, leading to activation of MDM2 E3-ligase activity and targeting of p53. We find that AKT phosphorylation of NPM-Ser48 prevents oligomerization that results in nucleoplasmic localization of ARF, constitutive MDM2 inhibition and stabilization of p53. We also show that ARF promotes p53 mutant stability in tumors and suppresses p73 mediated p21 expression and senescence. We demonstrate that AKT and PI3K inhibitors may be effective in treatment of therapeutically resistant tumors with elevated AKT and carrying gain of function mutations in p53. Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localization, reduced p53(mut) stability and increased sensitivity to ionizing radiation in a xenograft model of pancreatic cancer. Analysis of human tumors indicates that phospho-S48-NPM may be a useful biomarker for monitoring AKT activity and in vivo efficacy of AKT inhibitor treatment. Critically, we propose that combination therapy involving PI3K-AKT inhibitors would benefit from a patient stratification rationale based on ARF and p53(mut) status
Modelling the behaviour of microbulk Micromegas in Xenon/trimethylamine gas
We model the response of a state of the art micro-hole single-stage charge
amplication device (`microbulk' Micromegas) in a gaseous atmosphere consisting
of Xenon/trimethylamine at various concentrations and pressures. The amplifying
structure, made with photo-lithographic techniques similar to those followed in
the fabrication of gas electron multipliers (GEMs), consisted of a 100 um-side
equilateral-triangle pattern with 50 um-diameter holes placed at its vertexes.
Once the primary electrons are guided into the holes by virtue of an optimized
field configuration, avalanches develop along the 50 um-height channels etched
out of the original doubly copper-clad polyimide foil. In order to properly
account for the strong field gradients at the holes' entrance as well as for
the fluctuations of the avalanche process (that ultimately determine the
achievable energy resolution), we abandoned the hydrodynamic framework,
resorting to a purely microscopic description of the electron trajectories as
obtained from elementary cross-sections. We show that achieving a satisfactory
description needs additional assumptions about atom-molecule (Penning) transfer
reactions and charge recombination to be made
Cyan-Emitting Cu(I) Complexes and Their Luminescent Metallopolymers
Copper complexes have shown great versatility and a wide application range across the natural and life sciences, with a particular promise as organic light-emitting diodes. In this work, four novel heteroleptic Cu(I) complexes were designed in order to allow their integration in advanced materials such as metallopolymers. We herein present the synthesis and the electrochemical and photophysical characterisation of these Cu(I) complexes, in combination with ab initio calculations. The complexes present a bright cyan emission (λem ~ 505 nm) in their solid state, both as powder and as blends in a polymer matrix. The successful synthesis of metallopolymers embedding two of the novel complexes is shown. These copolymers were also found to be luminescent and their photophysical properties were compared to those of their polymer blends. The chemical nature of the polymer backbone contributes significantly to the photoluminescence quantum yield, paving a route for the strategic design of novel luminescent Cu(I)-based polymeric materials
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