Measure of Design M&As: Exploratory investigations of IP analysis in design

Despite active participation of design firms in M&A markets, there has been little research measuring the value of design M&As. It is partially due that design has been seen to be an intangible asset. This paper seeks to the understanding of the value of design M&As and provides a possible metric for measuring the value using patent analysis. The value of design M&A was investigated at two levels: Design as differentiator (i.e., new product development) and Design as coordinator or integrator (i.e., organizational growth). The evolution of patenting quantity (e.g., the number of design patent applications, Locarno classes) and quality (e.g., forward citation, coinventor networks) in pre- and post-acquisition deals was suggested. We conducted a case study using the design and utility patents of Adobe Systems Inc. The results show the dynamics of innovation area and the presence of the high values of inventors holding design-tech linkage, which could be a potential intangible source of company growth. This study further provides implications for companies which might consider design M&As as new ways of design investment

Electrochemical Production of Hydrogen Coupled with the Oxidation of Arsenite

The production of hydrogen accompanied by the simultaneous oxidation of arsenite (As(III)) was achieved using an electrochemical system that employed a BiO_x–TiO_2 semiconductor anode and a stainless steel (SS) cathode in the presence of sodium chloride (NaCl) electrolyte. The production of H_2 was enhanced by the addition of As(III) during the course of water electrolysis. The synergistic effect of As(III) on H_2 production can be explained in terms of (1) the scavenging of reactive chlorine species (RCS), which inhibit the production of H_2 by competing with water molecules (or protons) for the electrons on the cathode, by As(III) and (2) the generation of protons, which are more favorably reduced on the cathode than water molecules, through the oxidation of As(III). The addition of 1.0 mM As(III) to the electrolyte at a constant cell voltage (E_(cell)) of 3.0 V enhanced the production of H2 by 12% even though the cell current (I_(cell)) was reduced by 5%. The net effect results in an increase in the energy efficiency (EE) for H_2 production (ΔEE) by 17.5%. Furthermore, the value ΔEE, which depended on As(III) concentration, also depended on the applied E_(cell). For example, the ΔEE increased with increasing As(III) concentration in the micromolar range but decreased as a function of E_(cell). This is attributed to the fact that the reactions between RCS and As(III) are influenced by both RCS concentration depending on E_(cell) and As(III) concentration in the solution. On the other hand, the ΔEE decreased with increasing As(III) concentration in the millimolar range due to the adsorption of As(V) generated from the oxidation of As(III) on the semiconductor anode. In comparison to the electrochemical oxidation of certain organic compounds (e.g., phenol, 4-chlorophenol, 2-chlorophenol, salicylic acid, catechol, maleic acid, oxalate, and urea), the ΔEE obtained during As(III) oxidation (17.5%) was higher than that observed during the oxidation of the above organic compounds (ΔEE = 3.0–15.3%) with the exception of phenol at 22.1%. The synergistic effect of As(III) on H_2 production shows that an energetic byproduct can be produced during the remediation of a significant inorganic pollutant

Measure of Design M&As: Exploratory investigations of IP analysis in design

Despite active participation of design firms in M&A markets, there has been little research measuring the value of design M&As. It is partially due that design has been seen to be an intangible asset. This paper seeks to the understanding of the value of design M&As and provides a possible metric for measuring the value using patent analysis. The value of design M&A was investigated at two levels: Design as differentiator (i.e., new product development) and Design as coordinator or integrator (i.e., organizational growth). The evolution of patenting quantity (e.g., the number of design patent applications, Locarno classes) and quality (e.g., forward citation, coinventor networks) in pre- and post-acquisition deals was suggested. We conducted a case study using the design and utility patents of Adobe Systems Inc. The results show the dynamics of innovation area and the presence of the high values of inventors holding design-tech linkage, which could be a potential intangible source of company growth. This study further provides implications for companies which might consider design M&As as new ways of design investment

Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells

Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited β-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-α) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries

Cinacalcet lowering of serum fibroblast growth factor-23 concentration may be independent from serum Ca, P, PTH and dose of active vitamin D in peritoneal dialysis patients: a randomized controlled study

Background : Elevated serum level of fibroblast growth factor-23 (FGF23) is associated with adverse outcomes in dialyzed patients. Objectives : The CUPID study compared the efficacy of a cinacalcet-based regimen with conventional care (vitamin D and P binders) for achieving the stringent NKF-K/DOQI targets for peritoneal dialysis (PD) patients. Additionally, we analyzed change in FGF23 levels between two treatments to explore the cinacalcet effect in lowering FGF23. Design : Multicenter, open-labeled, randomized controlled study. Setting : Seven university-affiliated hospitals in Korea. Participants : Overall, 66 peritoneal dialysis patients were enrolled. Intervention : Sixty six patients were randomly assigned to treatment with either cinacalcet + oral vitamin D (cinacalcet group, n = 33) or oral vitamin D alone (control group, n = 33) to achieve K/DOQI targets. CUPID included a 4-week screening for vitamin D washout, a 12-week dose-titration, and a 4-week assessment phases. We calculated mean values of iPTH, Ca, P, Ca x P, during assessment phase and final FGF23 to assess the outcome. Main outcome measures : Achievement of >30% reduction of iPTH from baseline (primary) and FGF23 reduction (secondary). Results : 72.7% (n = 24) of the cinacalcet group and 93.9% (n = 31) of the control group completed the study. Cinacalcet group received 30.2 ± 18.0 mg/day of cinacalcet and 0.13 ± 0.32 μg/d oral vitamin D (P < 0.001 vs. control with 0.27 ± 0.18 μg/d vitamin D). The proportion of patients who reached the primary endpoint was not statistically different (48.5% vs. 51.5%, cinacalcet vs. control, P = 1.000). After treatment, cinacalcet group experienced a significant reduction in FGF23 levels (median value from 3,960 to 2,325 RU/ml, P = 0.002), while an insignificant change was shown for control group (from 2,085 to 2,415 RU/ml). The percent change of FGF23 after treatment was also significantly different between the two groups (− 42.54% vs. 15.83%, P = 0.008). After adjustment, cinacalcet treatment was independently associated with the serum FGF23 reduction. Conclusion : Cinacalcet treatment was independently associated with the reduction of FGF23 in our PD patients.The CUPID study was funded by Kyowa Kirin, Korea. However, the funding body had no role in the design, implementation, analysis of the study. Presented at the Kidney Week 2012 of the American Society of Nephrology, San Diego, CA, October 30- November 4, 2012. We thank the Medical Research Collaborating Center (MRCC), Seoul National University Hospital for the statistical advice.Peer Reviewe

Does Abdominal Obesity Accelerate the Effect of Hypertriglyceridemia on Impaired Fasting Glucose?

Purpose: This study sought to determine whether abdominal obesity is a risk factor for impaired fasting glucose (IFG) and hypertriglyceridemia and to verify whether moderate effect of abdominal obesity on the relationship between IFG and hypertriglyceridemia in Korea. Materials and Methods: Data from the Korean National Health and Nutrition Examination Survey was used for the analysis. The study population included 5,938 subjects aged 20 year old drawn from non-diabetic participants in a health examination survey. The subjects were classified according to the presence of abdominal obesity based on waist circumference, IFG based on their fasting blood glucose level, and hypertriglyceridemia on their fasting triglyceride. Results: The multivariate-adjusted odds ratios for the occurrence of hypertriglyceridemia were 2.91 in the abdominal obesity group as compared with the nonobesity group and 1.31 in subjects with IFG compared with the normoglycemia controls. Abdominal obesity was found to be positively moderated in the interaction between waist circumference and fasting blood sugar. Conclusion: The moderate effect between abdominal obesity and IFG contributes to the development of hypertriglyceridemia in Korea