Poly[(μ4-3-carb­oxy­benzoato-κ5 O 1:O 1,O 1′:O 1′:O 3)(quinolin-8-olato-κ2 N,O)lead(II)]

The asymmetric unit of the title complex, [Pb(C8H5O4)(C9H6NO)]n, comprises a PbII cation, a quinolin-8-olate anion and a 3-carb­oxy­benzoate anion. The coordination geometry of the PbII atom is defined by one N and six O atoms, as well as a stereochemically active lone pair of electrons, and is based on a Ψ-dodeca­hedron. The quinolin-8-olate is chelating and the 3-carb­oxy­benzoate anion forms bonds to four different PbII atoms. The benzoate end of the 3-carb­oxy­benzoate ligand chelates one PbII atom and simultaneously bridges two PbII atoms on either side, forming a chain along the b axis. The carboxyl end of the 3-carb­oxy­benzoate connects to a neighbouring chain by employing its carbonyl atom to form a bond to a PbII atom and the hydroxyl group to form a hydrogen bond to a quinolin-8-olate O atom. Thereby, a layer is formed in the bc plane

Pregnancy Outcomes Among Hospitalized Patients Infected With 2009 H1N1 Influenza Virus in Qom, Iran, in Oct-Nov. 2009

Background: Pandemic H1N1 influenza A 2009 (H1N1/09) virus has been identified as a leading cause of febrile respiratory diseases worldwide, and pregnant women constitute a high risk group. Objectives: To determine the clinical characteristics and outcomes of pregnant women with H1N1 influenza A hospitalized in university hospitals of Qom city in Iran. Patients and Methods: This descriptive retrospective study was conducted using existed data related to October and November 2009. All pregnant women with influenza manifestations were admitted to the hospitals to undergo nasopharyngeal culture. H1N1 virus was confirmed in 11 cases. Data including demographic characteristics, clinical manifestations, laboratory test results, and pregnancy complications was extracted from medical records, and analyzed by descriptive statistics. Results: The mean age of the women was 28.1 ± 4.7 years with a mean gestational age of 28.7 ± 10.9 weeks. The most common clinical manifestations included coughing (100%), fever (87.5%), and dyspnea (75%). The most common abnormal test was anemia (88%). Pregnancy complications included preterm delivery (36.3%), low birth weight (18%), oligohydramnios (9%), gestational diabetes (9%), and fetal distress (9%). Also one (12.5%) wound dehiscence happened. Conclusions: vaccination seems to be necessary to prevent this potentially fatal infectious disease. Furthermore, timely prescription of antiviral medications is recommended to decrease the risk of severe complications

catena-Poly[[lead(II)-bis­(μ2-quinolin-8-ol­ato)-κ3 N,O:O;κ3 O:N,O] N,N-di­methyl­formamide hemisolvate]

The asymmetric unit of the title compound, {[Pb(C9H6NO)2]·0.5C3H7NO}n, comprises Pb(quinolate)2 and half a dimethyl­formamide mol­ecule (which is disordered about a centre of inversion). The quinolate ligands N,O-chelate to a PbII ion and simultaneously bridge a neighbouring PbII ion to form a polymeric chain along [100] comprising Pb-linked Pb2O2 distorted rhombi. These chains pack to form a square grid, with the channels thus defined occupied by the disordered solvent mol­ecules

How Can We Identify Hijacked Journals?

By developing research and academic centers, the number of performed research articles has also increased. On the other hand, publishing the results of these articles in scientific journals shall also grow. In the meantime, researchers are trying to publish the findings of their research in journals which have been approved by one or more International indices so that such findings can be seen. In order to enhance the academic standards of Universities, proper journal choice will be of interest to researchers, especially those that are indexed in websites such as Thomson Reuters. However, certain forgery frauds researchers by launching fake Web sites that have been named by academic journal titles. In this paper, we introduce an approach to identify this type of journals that will be applicable by researchers in various academic disciplines

Dopaminergic D1 receptor signalling is necessary, but not sufficient for cued fear memory destabilisation

Rationale. Pharmacological targeting of memory reconsolidation is a promising therapeutic strategy for the treatment of fear memory-related disorders. However, the success of reconsolidation-based approaches depends upon the effective destabilisation of the fear memory by memory reactivation. Objectives. Here, we aimed to determine the functional involvement of dopamine D1 receptors in cued fear memory destabilisation, using systemic drug administration. Results. We observed that direct D1 receptor agonism was not sufficient to stimulate tone fear memory destabilisation to facilitate reconsolidation disruption by the glucocorticoid receptor antagonist mifepristone. Instead, administration of the nootropic nefiracetam did facilitate mifepristone-induced amnesia, in a manner that was dependent upon dopamine D1 receptor activation, although. Finally, while the combined treatment with nefiracetam and mifepristone did not confer fear-reducing effects under conditions of extinction learning, there was some evidence that mifepristone reduces fear expression irrespective of memory reactivation parameters. Conclusions. The use of combination pharmacological treatment to stimulate memory destabilisation and impair reconsolidation has potential therapeutic benefits, without risking a maladaptive increase of fear

Baseline characteristics of patients in the reduction of events with darbepoetin alfa in heart failure trial (RED-HF)

<p>Aims: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes.</p> <p>Methods and results: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate <60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106–117) g/L.</p> <p>Conclusion: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity.</p&gt

A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice

Several antihypertensive drugs, such as diuretics and β-blockers, can negatively affect sexual function, leading to diminished quality of life and often to noncompliance with the therapy. Other drug classes, however, such as angiotensin II receptor blockers (ARBs) are able to improve patients’ sexual function. Sufficient knowledge about the effects of these widely used antihypertensive drugs will make it possible for cardiologists and general practitioners to spare and even improve patients’ sexual health by switching to different classes of cardiac medication. Nevertheless, previous data (part I) indicate that most cardiologists lack knowledge about the effects cardiovascular agents can have on sexual function and will thus not be able to provide the necessary holistic patient care with regard to prescribing these drugs. To be able to improve healthcare on this point, we aimed to provide a practical overview, for use by cardiologists as well as other healthcare professionals, dealing with sexual dysfunction in their clinical practices. Therefore, a systematic review of the literature was performed. The eight most widely used classes of antihypertensive drugs have been categorised in a clear table, marking whether they have a positive, negative or no effect on sexual function