7,367 research outputs found
[μ-4-Benzoyl-1-(1-oxido-2-naphthylÂcarbonÂyl)thioÂsemicarbazidato(4−)]bisÂ[pyridineÂcopper(II)]
In the title dinuclear complex, [Cu2(C19H11N3O3S)(C5H5N)2], the two CuII centers have different coordination environments, viz. N2OS and N2O2, each exhibiting a distorted square-planar geometry. π–π interÂactions between the aromatic rings of neighbouring complexes [centroid–centroid distance = 3.856 (5) Å] link pairs of molÂecules into centrosymmetric dimers, which are further packed into stacks along the b axis with relatively short Cu⋯Cu separations of 3.482 (1) Å. Weak interÂmolecular C—H⋯N hydrogen bonds help to consolidate the crystal packing
Bis[μ-N′-acetyl-1-oxidonaphthalene-2-carbohydrazidato(3−)]tetraÂpyridineÂtricopper(II)
There are two half-molÂecules in the asymmetric unit of the title compound, [Cu3(C13H9N2O3)2(C5H5N)4], and crystallographic inversion symmetry completes each trinuclear molÂecule. In both molÂecules, the central Cu atom (site symmetry ) adopts a distorted trans-CuO2N4 octaÂhedral geometry, arising from its coordination by two N,O-bidentate aroylhydrazine ligands and two pyridine molÂecules. The peripheral Cu atoms adopt trans-CuN2O2 square-planar coordinations arising from an N,O,O-triÂdentate ligand (that also bonds to the central Cu atom) and a pyridine molÂecule
(1E)-6-MethÂoxy-3,4-dihydroÂnaphthalen-1(2H)-one oxime
In the crystal structure of the title compound, C11H13NO2, the molÂecules are paired into centrosymmetric dimers via interÂmolecular O—H⋯N hydrogen bonds
MicroRNA-483 amelioration of experimental pulmonary hypertension.
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit. Lower levels of miR-483 were found in serum from patients with idiopathic pulmonary arterial hypertension (IPAH), particularly those with more severe disease. RNA-seq and bioinformatics analyses showed that miR-483 targets several PAH-related genes, including transforming growth factor-β (TGF-β), TGF-β receptor 2 (TGFBR2), β-catenin, connective tissue growth factor (CTGF), interleukin-1β (IL-1β), and endothelin-1 (ET-1). Overexpression of miR-483 in ECs inhibited inflammatory and fibrogenic responses, revealed by the decreased expression of TGF-β, TGFBR2, β-catenin, CTGF, IL-1β, and ET-1. In contrast, inhibition of miR-483 increased these genes in ECs. Rats with EC-specific miR-483 overexpression exhibited ameliorated pulmonary hypertension (PH) and reduced right ventricular hypertrophy on challenge with monocrotaline (MCT) or Sugen + hypoxia. A reversal effect was observed in rats that received MCT with inhaled lentivirus overexpressing miR-483. These results indicate that PAH is associated with a reduced level of miR-483 and that miR-483 might reduce experimental PH by inhibition of multiple adverse responses
A data analysis method for isochronous mass spectrometry using two time-of-flight detectors at CSRe
The concept of isochronous mass spectrometry (IMS) applying two
time-of-flight (TOF) detectors originated many years ago at GSI. However, the
corresponding method for data analysis has never been discussed in detail.
Recently, two TOF detectors have been installed at CSRe and the new working
mode of the ring is under test. In this paper, a data analysis method for this
mode is introduced and tested with a series of simulations. The results show
that the new IMS method can significantly improve mass resolving power via the
additional velocity information of stored ions. This improvement is especially
important for nuclides with Lorentz factor -value far away from the
transition point of the storage ring CSRe.Comment: published in Chinese Physics C Vol. 39, No. 10 (2015) 10620
The color gradients of spiral disks in the Sloan Digital Sky Survey
We investigate the radial color gradients of galactic disks using a sample of
about 20,000 face-on spiral galaxies selected from the fourth data release of
the Sloan Digital Sky Survey (SDSS-DR4). We combine galaxies with similar
concentration, size and luminosity to construct composite galaxies, and then
measure their color profiles by stacking the azimuthally averaged radial color
profiles of all the member galaxies. Except for the smallest galaxies (R_{50}<3
kpc), almost all galaxies show negative disk color gradients with mean g-r
gradient G_{gr}=-0.006 mag kpc^{-1} and r-z gradient G_{rz}=-0.018 mag
kpc^{-1}. The disk color gradients are independent of the morphological types
of galaxies and strongly dependent on the disk surface brightness \mu_{d}, with
lower surface brightness galactic disks having steeper color gradients. We
quantify the intrinsic correlation between color gradients and surface
brightness as G_{gr}=-0.011\mu_{d}+0.233 and G_{rz}=-0.015\mu_{d}+0.324. These
quantified correlations provide tight observational constraints on the
formation and evolution models of spiral galaxies.Comment: 20 pages, 5 figures, Accepted for publication in RAA (Research in
Astronomy and Astrophysics
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