Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance

Towards a general framework for including noise impacts in LCA

Industrial Ecolog

Influence of consciousness, muscle action and activity on medial condyle translation after Oxford unicompartmental knee replacement

Background: Quantification of the in vivo position of the medial condyle throughout flexion is important for knee replacement design, and understanding knee pathology. The influence of consciousness, muscle action, and activity type on condyle translation was examined in patients who had undergone medial unicompartmental knee replacement (UKR) using lateral video fluoroscopy. Methods: The position of the centre of the femoral component relative to the tibial component was measured for 9 patients under different conditions. The following activities were assessed; passive flexion and extension when anaesthetised, passive flexion and extension when conscious, active flexion, extension and step-up. Results: The position of the centre of the femoral component relative to the tibial component was highly patient dependent. The greatest average translation range (14.9 mm) was observed in anaesthetised patients, and the condyle was significantly more anterior near to extension. Furthermore, when conscious but being moved passively, the femoral condyle translated a greater range (8.9 mm) than when moving actively (5.2 mm). When ascending stairs, the femoral condyle was more posterior at 20-30 degrees of flexion than during flexion/extension. Conclusions: The similarity between these results and published data suggest that knee kinematics following mobile-bearing UKR is relatively normal. The results show that in the normal knee and after UKR, knee kinematics is variable and is influenced by the patient, consciousness, muscle action, and activity type. Clinical relevance: It is therefore essential that all these factors are considered during knee replacement design, if the aim is to achieve more normal knee kinematics

Il laboratorio riflessivo: "Orientarsi nella vita: per un progetto di s\ue9 e delle proprie competenze educative"

Il contributo trae spunto dall'esperienza formativa condotta presso il Liceo Scientifico Statale "G.Salvemini" di Bari e illustra i risultati della ricerca-intervento sul tema dello sviluppo delle competenze pedagogiche genitoriali