The Role of Interactions in Systems of Single Domain Ferrimagnetic Iron Oxide Nanoparticles

Magnetic nanoparticles are interesting materials for a lot of medical and technical applications. A less experimentally investigated question is the influence of particle packing density on magnetic properties due to magnetic interactions between single particles. For this, magnetic nanoparticles of iron oxides prepared as fine dry powder by laser deposition are investigated with respect to their structural and magnetic properties as function of packing density. The particles are nearly spherically shaped single crystals in the magnetic single domain size range with a mean diameter of 21 nm occasionally exhibiting spinel growth facets. Powders of these particles are diluted by nonmagnetic silicon oxide particles in a range of volume concentrations from 0.2 % up to 68 % of the bulk density of magnetite. The concentration dependence of remanence, coercivity and hysteresis losses is determined by measurements of minor loops in a vibrating sample magnetometer. Results which are discussed in the frame of present theoretical models may be understood in terms of the cubic anisotropy of magnetite distorted by a small uniaxial shape contribution. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2778

Fractionation of magnetic microspheres in a microfluidic spiral: interplay between magnetic and hydrodynamic forces

Magnetic forces and curvature-induced hydrodynamic drag have both been studied and employed in continuous microfluidic particle separation and enrichment schemes. Here we combine the two. We investigate consequences of applying an outwardly directed magnetic force to a dilute suspension of magnetic microspheres circulating in a spiral microfluidic channel. This force is realized with an array of permanent magnets arranged to produce a magnetic field with octupolar symmetry about the spiral axis. At low flow rates particles cluster around an apparent streamline of the flow near the outer wall of the turn. At high flow rates this equilibrium is disrupted by the induced secondary (Dean) flow and a new equilibrium is established near the inner wall of the turn. A model incorporating key forces involved in establishing these equilibria is described, and is used to extract quantitative information about the magnitude of local Dean drag forces from experimental data. Steady-state fractionation of suspensions by particle size under the combined influence of magnetic and hydrodynamic forces is demonstrated. Extensions of this work could lead to new continuous microscale particle sorting and enrichment processes with improved fidelity and specificity

Heat dissipation in Sm3+ and Zn2+ co-substituted magnetite (Zn0.1SmxFe2.9-xO4) nanoparticles coated with citric acid and pluronic F127 for hyperthermia application

In this work, Sm3+ and Zn2+ co-substituted magnetite Zn0.1SmxFe2.9-xO4 (x = 0.0, 0.01, 0.02, 0.03, 0.04 and 0.05) nanoparticles, have been prepared via co-precipitation method and were electrostatically and sterically stabilized by citric acid and pluronic F127 coatings. The coated nanoparticles were well dispersed in an aqueous solution (pH 5.5). Magnetic and structural properties of the nanoparticles and their ferrofluids were studied by different methods. XRD studies illustrated that all as-prepared nanoparticles have a single phase spinel structure, with lattice constants affected by samarium cations substitution. The temperature dependence of the magnetization showed that Curie temperatures of the uncoated samples monotonically increased from 430 to 480 °C as Sm3+ content increased, due to increase in A-B super-exchange interactions. Room temperature magnetic measurements exhibited a decrease in saturation magnetization of the uncoated samples from 98.8 to 71.9 emu/g as the Sm3+ content increased, which is attributed to substitution of Sm3+ (1.5 µB) ions for Fe3+ (5 µB) ones in B sublattices. FTIR spectra confirmed that Sm3+ substituted Zn0.1SmxFe2.9-xO4 nanoparticles were coated with both citric acid and pluronic F127 properly. The mean particle size of the coated nanoparticles was 40 nm. Calorimetric measurements showed that the maximum SLP and ILP values obtained for Sm3+ substituted nanoparticles were 259 W/g and 3.49 nHm2/kg (1.08 mg/ml, measured at f = 290 kHz and H = 16kA/m), respectively, that are related to the sample with x = 0.01. Magnetic measurements revealed coercivity, which indicated that hysteresis loss may represent a substantial portion in heat generation. Our results show that these ferrofluids are potential candidates for magnetic hyperthermia applications

Biodegradable magnetic microspheres for drug targeting, temperature controlled drug release, and hyperthermia

Magnetic microspheres (MMS) used for magnetic drug targeting consist of magnetic nanoparticles (MNP) and a pharmaceutical agent embedded in a polymeric matrix material. The application of MNP for drug targeting enables guiding the MMS to a target area, imaging the position of the MMS with magnetic particle imaging, and finally inducing drug release. As latter takes place by degradation of the MMS or diffusion through the matrix, an increase in temperature, e.g. through magnetic hyperthermia, leads to an accelerated drug release. Here, MMS consisting of poly(lactic-coglycolic) acid (PLGA) with different monomer ratios were prepared by an oil-in-water emulsion evaporation method. The model drug Camptothecin (CPT) and magnetic multicore nanoparticles (MCNP) with a high specific heating rate were embedded into the microspheres. We obtained MMS in the preferred size range of 1 to 2 μm with a concentration of MCNP of 16wt%, a drug load of about 0.5wt% and an excellent heating performance of 161 W/gMMS. Investigations of the drug release behaviour showed an accelerated drug release when increasing the temperature from 20 °C to 37 °C or 43 °C by using a water bath. In addition, an increase in drug release of about 50% through magnetic heating of the MMS up to 44 °C compared to 37 °C was observed. By this, a magnetic hyperthermia induced CPT release from PLGA MMS is demonstrated for the very first time

Influence of Sterilization and Preservation Procedures on the Integrity of Serum Protein-Coated Magnetic Nanoparticles

Protein-coated magnetic nanoparticles are promising candidates for various medical applications. Prior to their application into a biological system, one has to guarantee that the particle dispersions are free from pathogens or any other microbiologic contamination. Furthermore, to find entrance into clinical routine, the nanoparticle dispersions have to be storable for several months. In this study, we tested several procedures for sterilization and preservation of nanoparticle containing liquids on their influence on the integrity of the protein coating on the surface of these particles. For this, samples were treated by freezing, autoclaving, lyophilization, and ultraviolet (UV) irradiation, and characterized by means of dynamic light scattering, determination of surface potential, and gel electrophoresis afterwards. We found that the UV sterilization followed by lyophilization under the addition of polyethylene glycol are the most promising procedures for the preparation of sterilized long-term durable protein-coated magnetic nanoparticles. Ongoing work is focused on the optimization of used protocols for UV sterilization and lyophilization for further improvement of the storage time

A multi-purpose phantom kit for magnetic particle imaging

Phantoms are essential tools for the development and characterization of Magnetic Particle Imaging (MPI), an imaging technique that can quantitatively map the spatial distribution of magnetic nanoparticles (MNP). The objective of this study was to develop and validate a modular MPI phantom kit with high versatility for platform-independent quality assurance and the assembling of defined geometries in MPI. It was shown that the developed MPI phantom kit can be used for both application scenario testing and quality assurance in MPI which provides the basis for future reference phantoms to directly compare existing scanners within the MPI community

Retinal vessel diameter variations and their correlation to arterial blood pressure

Purpose : The risk for cardiovascular diseases can be evaluated by the measuring of the retinal blood vessel diameters. Temporal variations in vessel diameter lead to uncertainties. Mayer waves are cyclic variations in cardiovascular system, which can be seen in arterial blood pressure. A link to retinal vessel diameters is known in general but temporal dependencies are not described yet. We investigated the similarity of these variations and determined the temporal dependencies in a multimodal measurement study. Methods : In a study in accordance with the Declaration of Helsinki we performed measurements on 15 young and healthy subjects. Within a time period of 90 minutes, six repeated measurements with a duration of six minutes each were conducted. We did a simultaneous measurement of retinal vessel diameters (Dynamic Vessel Analyzer, IMEDOS Systems UG, Jena, Germany) and non-invasive continuous arterial blood pressure (Finometer Pro, Finapres Medical Systems B.V., Enschede, The Netherlands). The sum of the diameters was calculated for both arteries and veins. We extracted waves in Very Low Frequency range (VLF, 0.02–0.07Hz) and Low Frequency range (LF, 0.07–0.15Hz) by filtering and determined temporal dependencies between both modalities using cross correlation. We extracted the lags of best signal correlation and calculated statistical parameters. Results : Cross correlation analysis showed clear dependencies in most of the 90 datasets. The strongest correlations were in VLF: minima of arteries: median -3.68 s, Interquartile range (IQR) 3.57, minima of veins: median -5.89 s, IQR 3.85 and in LF: minima of arteries: median -3.95 s, IQR 3.29, maxima of veins: median -0.10 s, IQR 0.98. Negative time lags mean retinal vessel diameter follows blood pressure signal. Distribution of the time shifts in LF was much closer than in VLF. Most of the outliers were shifted by one period. Correlation coefficients ranged up to 0.82 for frequencies in VLF and up to 0.94 in LF, randomly shifted outliers had lower correlation coefficients up to 0.4. Most outliers were concentrated on a few subjects. Conclusions : Our study showed clear dependencies between variations in retinal vessel diameter and arterial blood pressure. The best correlation could be seen in VLF on minima of arteries and veins and in LF on minima of arteries and maxima of veins, yielding the smallest variation in time shift and the smallest number of outliers

Structural properties of magnetic nanoparticles determine their heating behavior - an estimation of the in vivo heating potential

Magnetically induced heating of magnetic nanoparticles (MNP) in an alternating magnetic field (AMF) is a promising minimally invasive tool for localized tumor treatment by sensitizing or killing tumor cells with the help of thermal stress. Therefore, the selection of MNP exhibiting a sufficient heating capacity (specific absorption rate, SAR) to achieve satisfactory temperatures in vivo is necessary. Up to now, the SAR of MNP is mainly determined using ferrofluidic suspensions and may distinctly differ from the SAR in vivo due to immobilization of MNP in tissues and cells. The aim of our investigations was to study the correlation between the SAR and the degree of MNP immobilization in dependence of their physicochemical features. In this study, the included MNP exhibited varying physicochemical properties and were either made up of single cores or multicores. Whereas the single core MNP exhibited a core size of approximately 15 nm, the multicore MNP consisted of multiple smaller single cores (5 to 15 nm) with 65 to 175 nm diameter in total. Furthermore, different MNP coatings, including dimercaptosuccinic acid (DMSA), polyacrylic acid (PAA), polyethylenglycol (PEG), and starch, wereinvestigated. SAR values were determined after the suspension of MNP in water. MNP immobilization in tissues was simulated with 1% agarose gels and 10% polyvinyl alcohol (PVA) hydrogels. The highest SAR values were observed in ferrofluidic suspensions, whereas a strong reduction of the SAR after the immobilization of MNP with PVA was found. Generally, PVA embedment led to a higher immobilization of MNP compared to immobilization in agarose gels. The investigated single core MNP exhibited higher SAR values than the multicore MNP of the same core size within the used magnetic field parameters. Multicore MNP manufactured via different synthesis routes (fluidMAG-D, fluidMAG/12-D) showed different SAR although they exhibited comparable core and hydrodynamic sizes. Additionally, no correlation between ζ-potential and SAR values after immobilization was observed. Our data show that immobilization of MNP, independent of their physicochemical properties, can distinctly affect their SAR. Similar processes are supposed to take place in vivo, particularly when MNP are immobilized in cells and tissues. This aspect should be adequately considered when determining the SAR of MNP for magnetic hyperthermia

Collagen-iron oxide nanoparticle based ferrogel: Large reversible magnetostrains with potential for bioactuation

Smart materials such as stimuli responsive polymeric hydrogels offer unique possibilities for tissue engineering and regenerative medicine. As, however, most synthetic polymer systems and their degradation products lack complete biocompatibility and biodegradability, this study aims to synthesize a highly magnetic responsive hydrogel, based on the abundant natural biopolymer collagen. As the main component of vertebratal extracellular matrix, it reveals excellent biocompatibility. In combination with incorporated magnetic iron oxide nanoparticles, a novel smart nano-bio-ferrogel can be designed. While retaining its basic biophysical properties and interaction with living cells, this collagen-nanoparticle hydrogel can be compressed to 38% of its original size and recovers to 95% in suitable magnetic fields. Besides the phenomenology of this scenario, the underlying physical scenarios are also discussed within the framework of network models. The observed reversible peak strains as large as 150% open up possibilities for the fields of biomedical actuation, soft robotics and beyond. © 2020 The Author(s). Published by IOP Publishing Lt