2,978 research outputs found
Computational investigation of particle penetration and deposition pattern in a realistic respiratory tract model from different types of dry powder inhalers
The aim of this study was to evaluate the device performance of a new design by comparing with a typical commercial DPI. Computational fluid dynamics (CFD) coupled with the discrete element method (DEM) collision has been utilized in this study to characterize and examine the flow field and particle transportation, respectively. A typical commercial DPI and an in-house designed novel DPI with distinct design features were compared to explore their dispersion capabilities and suitability for delivery to the respiratory tract. For this exploration, realistic oral to larynx and tracheobronchial airway models consisting of bio-relevant features were adopted to enhance practical feasibility. Distinct aerosol performances were observed between the two DPIs in the respiratory tract, where the in-house DPI, in comparison with the commercial DPI, has shown approximately 30% lower deposition fraction in the mouth-throat region with approximately 7% higher escape rate in the tracheobronchial region under the identical inhalation condition. This observation demonstrates that a novel in-house designed DPI provides higher device efficiency over the selected typical commercial DPI
The Conformal Anomaly of M5-Branes
We show that the conformal anomaly for N M5-branes grows like . The
method we employ relates Coulomb branch interactions in six dimensions to
interactions in four dimensions using supersymmetry. This leads to a relation
between the six-dimensional conformal anomaly and the conformal anomaly of N=4
Yang-Mills. Along the way, we determine the structure of the four derivative
interactions for the toroidally compactified (2,0) theory, while encountering
interesting novelties in the structure of the six derivative interactions.Comment: 38 pages, LaTeX; references adde
Minimal Gaugomaly Mediation
Mixed anomaly and gauge mediation ("gaugomaly'' mediation) gives a natural
solution to the SUSY flavor problem with a conventional LSP dark matter
candidate. We present a minimal version of gaugomaly mediation where the
messenger masses arise directly from anomaly mediation, automatically
generating a messenger scale of order 50 TeV. We also describe a simple
relaxation mechanism that gives rise to realistic mu and B mu terms. B is
naturally dominated by the anomaly-mediated contribution from top loops, so the
mu/B mu sector only depends on a single new parameter. In the minimal version
of this scenario the full SUSY spectrum is determined by two continuous
parameters (the anomaly- and gauge-mediated SUSY breaking masses) and one
discrete parameter (the number of messengers). We show that these simple models
can give realistic spectra with viable dark matter.Comment: 18 pages, 4 figures; v2: corrected example generating non-holomorphic
Kahler term
D-brane anomaly inflow revisited
Axial and gravitational anomaly of field theories, when embedded in string
theory, must be accompanied by canceling inflow. We give a self-contained
overview for various world-volume theories, and clarify the role of smeared
magnetic sources in I-brane/D-brane cases. The proper anomaly descent of the
source, as demanded by regularity of RR field strengths H's, turns out to be an
essential ingredient. We show how this allows correct inflow to be generated
for all such theories, including self-dual cases, and also that the mechanism
is now insensitive to the choice between the two related but inequivalent forms
of D-brane Chern-Simons couplings. In particular, SO(6)_R axial anomaly of d=4
maximal SYM is canceled by the inflow onto D3-branes via the standard minimal
coupling to C_4. We also propose how, for the anomaly cancelation, the four
types of Orientifold planes should be coupled to the spacetime curvatures, of
which conflicting claims existed previously.Comment: 41 pages, references updated; version to appear in JHE
High frequency diffraction of an electromagnetic plane wave by an imperfectly conducting rectangular cylinder
Copyright @ 2011 IEEEWe shall consider the the problem of determining the scattered far wave field produced when a plane E-polarized wave is incident on an imperfectly conducting rectangular cylinder. By using the the uniform asymptotic solution for the problem of the diffraction of a plane wave by a right-angled impedance wedge, in conjunction with Keller's method, the a high frequency far field solution to the problem is given
Seroprevalence of Mycoplasma bovis infection in dairy cows in subtropical southern China
The seroprevalence of Mycoplasma bovis infection in dairy cows in Guangxi Zhuang Autonomous Region (GZAR) in subtropical southern China was surveyed between June 2009 and March 2010. A total of 455 serum samples of dairy cows were collected from 6 districts in 4 different cities, and examined for M. bovis antibodies with the indirect enzyme-linked immunosorbent assay (ELISA) using a commercially available kit. The overall seroprevalence of M. bovis infection in dairy cows was 7.69% (35/455). Three year-old dairy cows had the highest seroprevalence (15.0%), followed by dairy cows of 4 year-old (11.1%). Dairy cows with the history of 5 pregnancies had the highest seroprevalence (33.3%). However, no statistically significant association was found between M. bovis infection and age or number of pregnancies (p > 0.05). All the aborting dairy cows were negative for M. bovis antibodies, suggesting that bovine abortion may have no association with M. bovis infection in GZAR. These results indicate that M. bovis infection in dairy cows was widespread in GZAR, and integrated strategies and measures should be performed to control and prevent M. bovis infection and disease outbreak.Key words: Mycoplasma bovis, seroprevalence, dairy cows, Guangxi Zhuang Autonomous Region (GZAR), China, enzyme-linked immunosorbent assay (ELISA)
Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD
Mouse models for preeclampsia: disruption of redox-regulated signaling
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia-like symptoms (high
blood pressure, albuminurea and preterm birth) resulting from extensive vasculo-endothelial pathology, primarily at the utero-fetal interface where maternal cardiac output is dramatically increased during pregnancy. Comt converts estradiol to 2-methoxyestradiol 2 (2ME2) which
counters angiogenesis by depleting hypoxia inducible factor-1 alpha (HIF-1 alpha) at late pregnancy. We propose that in wild type (Comt++) pregnant mice, 2ME2 destabilizes HIF-1 alpha by inhibiting mitochondrial superoxide dismutase (MnSOD). Thus, 2ME2 acts as a pro-oxidant, disrupting
redox-regulated signaling which blocks angiogenesis in wild type (WT) animals in physiological pregnancy. Further, we suggest that a lack of this inhibition under normoxic conditions in mutant animals (Comt-/-) stabilises HIF-1 alpha by inactivating prolyl hydroxlases (PHD). We predict that a lack of inhibition of MnSOD, leading to persistent accumulation of HIF-1 alpha, would trigger
inflammatory infiltration and endothelial damage in mutant animals. Critical tests of this hypothesis would be to recreate preeclampsia symptoms by inducing oxidative stress in WT animals or to ameliorate by treating mutant mice with Mn-SOD-catalase mimetics or activators of PHD
Validity of the Polar V800 heart rate monitor to measure RR intervals at rest
Purpose To assess the validity of RR intervals and short-term heart rate variability (HRV) data obtained from the Polar V800 heart rate monitor, in comparison to an electrocardiograph (ECG). Method Twenty participants completed an active orthostatic test using the V800 and ECG. An improved method for the identification and correction of RR intervals was employed prior to HRV analysis. Agreement of the data was assessed using intra-class correlation coefficients (ICC), Bland–Altman limits of agreement (LoA), and effect size (ES). Results A small number of errors were detected between ECG and Polar RR signal, with a combined error rate of 0.086 %. The RR intervals from ECG to V800 were significantly different, but with small ES for both supine corrected and standing corrected data (ES 0.999 for both supine and standing corrected intervals. When analysed with the same HRV software no significant differences were observed in any HRV parameters, for either supine or standing; the data displayed small bias and tight LoA, strong ICC (>0.99) and small ES (≤0.029). Conclusions The V800 improves over previous Polar models, with narrower LoA, stronger ICC and smaller ES for both the RR intervals and HRV parameters. The findings support the validity of the Polar V800 and its ability to produce RR interval recordings consistent with an ECG. In addition, HRV parameters derived from these recordings are also highly comparable
On instantons as Kaluza-Klein modes of M5-branes
Instantons and W-bosons in 5d maximally supersymmetric Yang-Mills theory
arise from a circle compactification of the 6d (2,0) theory as Kaluza-Klein
modes and winding self-dual strings, respectively. We study an index which
counts BPS instantons with electric charges in Coulomb and symmetric phases. We
first prove the existence of unique threshold bound state of (noncommutative)
U(1) instantons for any instanton number, and also show that charged instantons
in the Coulomb phase correctly give the degeneracy of SU(2) self-dual strings.
By studying SU(N) self-dual strings in the Coulomb phase, we find novel
momentum-carrying degrees on the worldsheet. The total number of these degrees
equals the anomaly coefficient of SU(N) (2,0) theory. We finally show that our
index can be used to study the symmetric phase of this theory, and provide an
interpretation as the superconformal index of the sigma model on instanton
moduli space.Comment: 54 pages, 2 figures. v2: references added, figure improved, added
comments on self-dual string anomaly, added new materials on the symmetric
phase index, other minor correction
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