Aloe Vera – Nature’s Power

Aloe vera is a plant used in various fields like Homeopathy, Ayurveda, Allopathy, Siddha, Unani, cosmetology, dermatology and surprisingly even in dentistry. Aloe vera is richest source of health for humans with various benefits and properties like wound healing, anti-microbial, anti-inflammatory, immunomodulatory, anti-septic, anti-helmenthic and anti-oxidant. Aloe vera is used in dentistry as active ingredient in tooth pastes, tooth gels and mouth rinse for plaque control, treatment of various oral lesions, halitosis and gingivitis, as decontaminant in endodontics, in extraction sockets, dental implants and in denture care. This paper gives an overview of aloe vera plant, its ingredients, properties and various therapeutic and dental applications

EFFECT OF ANHEDRAL AND DIHEDRAL ON THE LATERAL DIRECTIONAL STATIC STABILITY OF THE AIRCRAFT

Developments and advancements in Aircraft industry have led to an increasing the stability and maneuverability of an aircraft. When the aircraft subjected to unbalanced force it needs the suitable wing to overcome the side slip and maneuverability of an aircraft. This work proposed a Dihedral and Anhedral wing simulation in XFLR5 software to increase the stability and maneuverability of an aircraft. XFLR5 analysis was then carried out for Dihedral and anhedral angles of 5deg, 10deg ,with side slip angles 2deg and 5deg. The aerofoil used in wing is NACA 4412 and in tail is 0009..Lateral-Directional Static Stability of 5,10 deg of both anhedral and dihedral wings are analyzed. The graphs are plotted between co-efficient of rolling moment and side slip angle ; co-efficient of yawing moment and side slip angle. The simulation is done in a free stream velocity of 60 m/s and inviscid flow. Anhedral is a negative dihedral angle .The anhedral reduces the dihedral effect bringing the wing\u27s roll characteristics into a more desirable performance envelope while keeping it stable yet maneuverable.Dihedral is the upward angle of an aircraft\u27s wings, which increases lateral stability in a bank by causing the lower wing to fly at a higher angle of attack than the higher wing

TALENT ACQUISITION IN AMARA RAJA BATTRIES PVT LTD., TIRUPATI

The purpose of this study is to look into how the use of artificial intelligence (AI) has been applied to the recruitment and selection of job candidates. This study specifically looks at the use of AI technology throughout the employment process in terms of its degree, pace, and prospective application areas. Descriptive research design was used for examining an attrition rate. A questionnaire covering various aspects relating to the recruitment and selection in the company where focused. 120 samples were collected using the random sampling technique. Hypothesis for the study were tested using correlation, analysis of variance method. The result shows that Which media is ideal for recruitment efforts and Is there any bias in the selection of employees in the organization

Viral Mediated Redirection of NEMO/IKKγ to Autophagosomes Curtails the Inflammatory Cascade

The early host response to viral infections involves transient activation of pattern recognition receptors leading to an induction of inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). Subsequent activation of cytokine receptors in an autocrine and paracrine manner results in an inflammatory cascade. The precise mechanisms by which viruses avert an inflammatory cascade are incompletely understood. Nuclear factor (NF)-κB is a central regulator of the inflammatory signaling cascade that is controlled by inhibitor of NF-κB (IκB) proteins and the IκB kinase (IKK) complex. In this study we show that murine cytomegalovirus inhibits the inflammatory cascade by blocking Toll-like receptor (TLR) and IL-1 receptor-dependent NF-κB activation. Inhibition occurs through an interaction of the viral M45 protein with the NF-κB essential modulator (NEMO), the regulatory subunit of the IKK complex. M45 induces proteasome-independent degradation of NEMO by targeting NEMO to autophagosomes for subsequent degradation in lysosomes. We propose that the selective and irreversible degradation of a central regulatory protein by autophagy represents a new viral strategy to dampen the inflammatory response

p53 status of newly established acute myeloid leukaemia cell lines

We analysed the status of the p53 gene and protein in eight newly established acute myeloid leukaemia (AML) cell lines representing blast cells of either de novo leukaemia patients in first remission or patients with relapsed and chemotherapy-resistant disease causing their death. There were no mutations in the p53 gene in any of the cell lines as analysed by single-strand conformation polymorphism of amplified exons 5–8. However, the p53 protein was clearly and consistently expressed in all of these cell lines, as shown by immunohistochemistry, Western blotting and flow cytometry. The consistently expressed p53 protein was located in both the nucleus and the cytoplasm of all the cell lines and, as shown by flow cytometry, it was mostly in a conformation typical of the mutated protein. These AML cell lines offer a tool for studying the production and function of the p53 protein and its possible role in cell cycle regulation and chemoresistance as well as in the regulation of apoptosis in AML. © 1999 Cancer Research Campaig

A Wide Extent of Inter-Strain Diversity in Virulent and Vaccine Strains of Alphaherpesviruses

Alphaherpesviruses are widespread in the human population, and include herpes simplex virus 1 (HSV-1) and 2, and varicella zoster virus (VZV). These viral pathogens cause epithelial lesions, and then infect the nervous system to cause lifelong latency, reactivation, and spread. A related veterinary herpesvirus, pseudorabies (PRV), causes similar disease in livestock that result in significant economic losses. Vaccines developed for VZV and PRV serve as useful models for the development of an HSV-1 vaccine. We present full genome sequence comparisons of the PRV vaccine strain Bartha, and two virulent PRV isolates, Kaplan and Becker. These genome sequences were determined by high-throughput sequencing and assembly, and present new insights into the attenuation of a mammalian alphaherpesvirus vaccine strain. We find many previously unknown coding differences between PRV Bartha and the virulent strains, including changes to the fusion proteins gH and gB, and over forty other viral proteins. Inter-strain variation in PRV protein sequences is much closer to levels previously observed for HSV-1 than for the highly stable VZV proteome. Almost 20% of the PRV genome contains tandem short sequence repeats (SSRs), a class of nucleic acids motifs whose length-variation has been associated with changes in DNA binding site efficiency, transcriptional regulation, and protein interactions. We find SSRs throughout the herpesvirus family, and provide the first global characterization of SSRs in viruses, both within and between strains. We find SSR length variation between different isolates of PRV and HSV-1, which may provide a new mechanism for phenotypic variation between strains. Finally, we detected a small number of polymorphic bases within each plaque-purified PRV strain, and we characterize the effect of passage and plaque-purification on these polymorphisms. These data add to growing evidence that even plaque-purified stocks of stable DNA viruses exhibit limited sequence heterogeneity, which likely seeds future strain evolution