Un educatore "in punta di piedi": l'educativa domiciliare dentro e oltre la pandemia

La tutela dei minori utilizza modalit\ue0 di cura educativa diverse: una delle pi\uf9 rispet- tose, della fragilit\ue0 e della resilienza familiare, \ue8 l\u2019educativa domiciliare. Gli inter- venti educativi domiciliari richiedono una professionalit\ue0 volta a promuovere cam- biamento, secondo criteri di rispetto, di delicata attenzione all\u2019intimit\ue0 dei nuclei e di apertura alle diverse forme di realizzazione del sistema \u201cfamiglia\u201d. Il tempo del- la pandemia ha confermato alcuni elementi di fondamento educativo di questo par- ticolare servizio e ha richiesto modalit\ue0 di intervento nuove, faticose ma generative

Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis

Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background (''Dutch hypothesis''). We investigated whether asthma and COPD have common underlying genetic factors, performing genome-wide association studies for both asthma and COPD and combining the results in meta-analyses. Three loci showed potential involvement in both diseases: chr2p24.3, chr5q23.1 and chr13q14.2, containing DDX1, COMMD10 (both participating in the nuclear factor (NF) κβ pathway) and GNG5P5, respectively. Single nucleotide polymorphisms (SNPs) rs9534578 in GNG5P5 reached genome-wide significance after first replication phase (p=9.96×10-9). The second replication phase, in seven independent cohorts, provided no significant replication. Expression quantitative trait loci (eQTL) analysis in blood cells and lung tissue on the top 20 associated SNPs identified two SNPs in COMMD10 that influenced gene expression. Inflammatory processes differ in asthma and COPD and are mediated by NF-κβ, which could be driven by the same underlying genes, COMMD10 and DDX1. None of the SNPs reached genome-wide significance. Our eQTL studies support a functional role for two COMMD10 SNPs, since they influence gene expression in both blood cells and lung tissue. Our findings suggest that there is either no common genetic component in asthma and COPD or, alternatively, different environmental factors, e.g. lifestyle and occupation in different countries and continents, which may have obscured the genetic common contribution. Copyrigh