474 research outputs found
Logarithmic Corrections to Schwarzschild and Other Non-extremal Black Hole Entropy in Different Dimensions
Euclidean gravity method has been successful in computing logarithmic
corrections to extremal black hole entropy in terms of low energy data, and
gives results in perfect agreement with the microscopic results in string
theory. Motivated by this success we apply Euclidean gravity to compute
logarithmic corrections to the entropy of various non-extremal black holes in
different dimensions, taking special care of integration over the zero modes
and keeping track of the ensemble in which the computation is done. These
results provide strong constraint on any ultraviolet completion of the theory
if the latter is able to give an independent computation of the entropy of
non-extremal black holes from microscopic description. For Schwarzschild black
holes in four space-time dimensions the macroscopic result seems to disagree
with the existing result in loop quantum gravity.Comment: LaTeX, 40 pages; corrected small typos and added reference
Can spacetime curvature induced corrections to Lamb shift be observable?
The Lamb shift results from the coupling of an atom to vacuum fluctuations of
quantum fields, so corrections are expected to arise when the spacetime is
curved since the vacuum fluctuations are modified by the presence of spacetime
curvature. Here, we calculate the curvature-induced correction to the Lamb
shift outside a spherically symmetric object and demonstrate that this
correction can be remarkably significant outside a compact massive
astrophysical body. For instance, for a neutron star or a stellar mass black
hole, the correction is 25% at a radial distance of ,
16% at and as large as 1.6% even at , where is
the mass of the object, the Newtonian constant, and the speed of light.
In principle, we can look at the spectra from a distant compact super-massive
body to find such corrections. Therefore, our results suggest a possible way of
detecting fundamental quantum effects in astronomical observations.Comment: 13 pages, 3 figures, slight title change, clarifications and more
discussions added, version to be published in JHE
Particle creation rate for dynamical black holes
We present the particle creation probability rate around a general black hole
as an outcome of quantum fluctuations. Using the uncertainty principle for
these fluctuation, we derive a new ultraviolet frequency cutoff for the
radiation spectrum of a dynamical black hole. Using this frequency cutoff, we
define the probability creation rate function for such black holes. We consider
a dynamical Vaidya model, and calculate the probability creation rate for this
case when its horizon is in a slowly evolving phase. Our results show that one
can expect the usual Hawking radiation emission process in the case of a
dynamical black hole when it has a slowly evolving horizon. Moreover,
calculating the probability rate for a dynamical black hole gives a measure of
when Hawking radiation can be killed off by an incoming flux of matter or
radiation. Our result strictly suggests that we have to revise the Hawking
radiation expectation for primordial black holes that have grown substantially
since they were created in the early universe. We also infer that this
frequency cut off can be a parameter that shows the primordial black hole
growth at the emission moment.Comment: 10 pages, 1 figure. The paper was rewritten in more clear
presentation and one more appendix is adde
Logarithmic correction to BH entropy as Noether charge
We consider the role of the type-A trace anomaly in static black hole
solutions to semiclassical Einstein equation in four dimensions. Via Wald's
Noether charge formalism, we compute the contribution to the entropy coming
from the anomaly induced effective action and unveil a logarithmic correction
to the Bekenstein-Hawking area law.
The corrected entropy is given by a seemingly universal formula involving the
coefficient of the type-A trace anomaly, the Euler characteristic of the
horizon and the value at the horizon of the solution to the uniformization
problem for Q-curvature. Two instances are examined in detail: Schwarzschild
and a four-dimensional massless topological black hole. We also find agreement
with the logarithmic correction due to one-loop contribution of conformal
fields in the Schwarzschild background.Comment: 14 pages, JHEP styl
Experimental loophole-free violation of a Bell inequality using entangled electron spins separated by 1.3 km
For more than 80 years, the counterintuitive predictions of quantum theory
have stimulated debate about the nature of reality. In his seminal work, John
Bell proved that no theory of nature that obeys locality and realism can
reproduce all the predictions of quantum theory. Bell showed that in any local
realist theory the correlations between distant measurements satisfy an
inequality and, moreover, that this inequality can be violated according to
quantum theory. This provided a recipe for experimental tests of the
fundamental principles underlying the laws of nature. In the past decades,
numerous ingenious Bell inequality tests have been reported. However, because
of experimental limitations, all experiments to date required additional
assumptions to obtain a contradiction with local realism, resulting in
loopholes. Here we report on a Bell experiment that is free of any such
additional assumption and thus directly tests the principles underlying Bell's
inequality. We employ an event-ready scheme that enables the generation of
high-fidelity entanglement between distant electron spins. Efficient spin
readout avoids the fair sampling assumption (detection loophole), while the use
of fast random basis selection and readout combined with a spatial separation
of 1.3 km ensure the required locality conditions. We perform 245 trials
testing the CHSH-Bell inequality and find . A
null hypothesis test yields a probability of that a local-realist
model for space-like separated sites produces data with a violation at least as
large as observed, even when allowing for memory in the devices. This result
rules out large classes of local realist theories, and paves the way for
implementing device-independent quantum-secure communication and randomness
certification.Comment: Raw data will be made available after publicatio
Logarithmic Corrections to Extremal Black Hole Entropy from Quantum Entropy Function
We evaluate the one loop determinant of matter multiplet fields of N=4
supergravity in the near horizon geometry of quarter BPS black holes, and use
it to calculate logarithmic corrections to the entropy of these black holes
using the quantum entropy function formalism. We show that even though
individual fields give non-vanishing logarithmic contribution to the entropy,
the net contribution from all the fields in the matter multiplet vanishes. Thus
logarithmic corrections to the entropy of quarter BPS black holes, if present,
must be independent of the number of matter multiplet fields in the theory.
This is consistent with the microscopic results. During our analysis we also
determine the complete spectrum of small fluctuations of matter multiplet
fields in the near horizon geometry.Comment: LaTeX file, 52 pages; v2: minor corrections, references adde
Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection
Protection of the brain from viral infections involves the type I interferon (IFN-I) system, defects in which renders humans susceptible to herpes simplex encephalitis (HSE). However, excessive cerebral IFN-I levels leads to pathologies, suggesting the need for tight regulation of responses. Based on data from mouse models, human HSE cases, and primary cell culture systems, we here show that microglia and other immune cells undergo apoptosis in the HSV-1-infected brain through a mechanism dependent on the cyclic GMP-AMP synthase (cGAS) - stimulator of interferon genes (STING) pathway, but independent of IFN-I. HSV-1 infection of microglia induced cGAS-dependent apoptosis at high viral doses, while lower viral doses led to IFN-I responses. Importantly, inhibition of caspase activity prevented microglial cell death and augmented IFN-I responses. Accordingly, HSV-1-infected organotypic brain slices, or mice treated with caspase inhibitor, exhibited lower viral load and improved outcome of infection. Collectively, we identify an activation-induced apoptosis program in brain immune cells which down-modulates local immune responses
Structure and function of mammalian cilia
In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease
Stochastic Gravity: Theory and Applications
Whereas semiclassical gravity is based on the semiclassical Einstein equation
with sources given by the expectation value of the stress-energy tensor of
quantum fields, stochastic semiclassical gravity is based on the
Einstein-Langevin equation, which has in addition sources due to the noise
kernel. In the first part, we describe the fundamentals of this new theory via
two approaches: the axiomatic and the functional. In the second part, we
describe three applications of stochastic gravity theory. First, we consider
metric perturbations in a Minkowski spacetime, compute the two-point
correlation functions of these perturbations and prove that Minkowski spacetime
is a stable solution of semiclassical gravity. Second, we discuss structure
formation from the stochastic gravity viewpoint. Third, we discuss the
backreaction of Hawking radiation in the gravitational background of a black
hole and describe the metric fluctuations near the event horizon of an
evaporating black holeComment: 100 pages, no figures; an update of the 2003 review in Living Reviews
in Relativity gr-qc/0307032 ; it includes new sections on the Validity of
Semiclassical Gravity, the Stability of Minkowski Spacetime, and the Metric
Fluctuations of an Evaporating Black Hol
History of sentinel node and validation of the technique
Sentinel node biopsy is a minimally invasive technique to select patients with occult lymph node metastases who may benefit from further regional or systemic therapy. The sentinel node is the first lymph node reached by metastasising cells from a primary tumour. Attempts to remove this node with a procedure based on standard anatomical patterns did not become popular. The development of the dynamic technique of intraoperative lymphatic mapping in the 1990s resulted in general acceptance of the sentinel node concept. This hypothesis of sequential tumour dissemination seems to be valid according to numerous studies of sentinel node biopsy with confirmatory regional lymph node dissection. This report describes the history and the validation of the technique, with particular reference to breast cancer
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