Imaging the disc rim and a moving close-in companion candidate in the pre-transitional disc of V1247 Orionis

This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.Context. V1247 Orionis harbours a pre-transitional disc with a partially cleared gap. Earlier interferometric and polarimetric observations revealed strong asymmetries both in the gap region and in the outer disc. The presence of a companion was inferred to explain these asymmetric structures and the ongoing disc clearing. Aims. Using an extensive set of multi-wavelength and multi-epoch observations we aimed to identify the origin of the previously detected asymmetries. Methods. We observed V1247 Ori at three epochs spanning ∼ 678 days using sparse aperture masking interferometry with Keck/NIRC2 and VLT/NACO. In addition, we search for signs of accretion through VLT/SPHERE-ZIMPOL spectral differential imaging in Hα and R-band continuum. Our SMA sub-millimetre interferometry in 880 µm continuum and in the CO(3-2) line allows us to constrain the orientation and direction of rotation of the outer disc. Results. We find the L’-band emission to be dominated by static features which trace forward-scattered dust emission from the inner edge of the outer disc located to the north-east. In H- and K-band, we see evidence for a companion candidate that moved systematically by 45◦ within the first ∼345 days. The separation of the companion candidate is not well constrained, but the observed position angle change is consistent with Keplerian motion of a body located on a 6 au orbit. From the SMA CO moment map, the location of the disc rim, and the detected orbital motion, we deduced the 3-dimensional orientation of the disc. We see no indication of accretion in Hα and set upper limits for an accreting companion. Conclusions. The measured contrast of the companion candidate in H and K is consistent with an actively accreting protoplanet. Hence, we identify V1247 Ori as a unique laboratory for studying companion-disc interactions and disc clearing.We acknowledge support from an ERC Starting Grant (Grant Agreement No. 639889), STFC Rutherford Fellowship Article number, page 14 of 17 M. Willson et al.: Imaging the disc rim and companion candidate in V1247 Ori (ST/J004030/1), STFC Rutherford Grant (ST/K003445/1), Marie SklodowskaCurie CIG grant (Ref. 618910), and Philip Leverhulme Prize (PLP-2013-110). We additionally acknowledge support from NASA KPDA grants (JPL-1452321, 1474717, 1485953, 1496788). The Submillimeter Array is a joint project between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics and is funded by the Smithsonian Institution and the Academia Sinica. The authors wish to recognize and acknowledge the very significant cultural role and reverence that the summit of Mauna Kea has always had within the indigenous Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain.Some of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation. J. Kluska acknowledges support from the research council of the KU Leuven under grant number C14/17/082. M. Curé and S. Kanaan acknowledge financial support from Centro de Astrofísica de Valparaiso. S. Kanaan thank the support of Fondecyt iniciacíon grant No. 11130702. T. Muto is partially supported by JSPS KAKENHI grant No. 26800106

Ultra-stable optical clock with two cold-atom ensembles

Atomic clocks based on optical transitions are the most stable, and therefore precise, timekeepers available. These clocks operate by alternating intervals of atomic interrogation with dead time required for quantum state preparation and readout. This non-continuous interrogation of the atom system results in the Dick effect, an aliasing of frequency noise of the laser interrogating the atomic transition. Despite recent advances in optical clock stability achieved by improving laser coherence, the Dick effect has continually limited optical clock performance. Here we implement a robust solution to overcome this limitation: a zero-dead-time optical clock based on the interleaved interrogation of two cold-atom ensembles. This clock exhibits vanishingly small Dick noise, thereby achieving an unprecedented fractional frequency instability of $6 \times 10^{-17} / \sqrt{\tau}$ for an averaging time $\tau$ in seconds. We also consider alternate dual-atom-ensemble schemes to extend laser coherence and reduce the standard quantum limit of clock stability, achieving a spectroscopy line quality factor $Q> 4 \times 10^{15}$

Estimating the Fitness Cost of Escape from HLA Presentation in HIV-1 Protease and Reverse Transcriptase

Human immunodeficiency virus (HIV-1) is, like most pathogens, under selective pressure to escape the immune system of its host. In particular, HIV-1 can avoid recognition by cytotoxic T lymphocytes (CTLs) by altering the binding affinity of viral peptides to human leukocyte antigen (HLA) molecules, the role of which is to present those peptides to the immune system. It is generally assumed that HLA escape mutations carry a replicative fitness cost, but these costs have not been quantified. In this study, we assess the replicative cost of mutations which are likely to escape presentation by HLA molecules in the region of HIV-1 protease and reverse transcriptase. Specifically, we combine computational approaches for prediction of in vitro replicative fitness and peptide binding affinity to HLA molecules. We find that mutations which impair binding to HLA-A molecules tend to have lower in vitro replicative fitness than mutations which do not impair binding to HLA-A molecules, suggesting that HLA-A escape mutations carry higher fitness costs than non-escape mutations. We argue that the association between fitness and HLA-A binding impairment is probably due to an intrinsic cost of escape from HLA-A molecules, and these costs are particularly strong for HLA-A alleles associated with efficient virus control. Counter-intuitively, we do not observe a significant effect in the case of HLA-B, but, as discussed, this does not argue against the relevance of HLA-B in virus control. Overall, this article points to the intriguing possibility that HLA-A molecules preferentially target more conserved regions of HIV-1, emphasizing the importance of HLA-A genes in the evolution of HIV-1 and RNA viruses in general

Gemini-LIGHTS: Herbig Ae/Be and massive T-Tauri protoplanetary disks imaged with Gemini Planet Imager

This is the final version. Available on open access from the American Astronomical Society via the DOI in this recordWe present the complete sample of protoplanetary disks from the Gemini- Large Imaging with GPI Herbig/T-tauri Survey (Gemini-LIGHTS) which observed bright Herbig Ae/Be stars and T-Tauri stars in near-infrared polarized light to search for signatures of disk evolution and ongoing planet formation. The 44 targets were chosen based on their near- and mid-infrared colors, with roughly equal numbers of transitional, pre-transitional, and full disks. Our approach explicitly did not favor well-known, “famous” disks or those observed by ALMA, resulting in a less-biased sample suitable to probe the major stages of disk evolution during planet formation. Our optimized data reduction allowed polarized flux as low as 0.002% of the stellar light to be detected, and we report polarized scattered light around 80% of our targets. We detected point-like companions for 47% of the targets, including 3 brown dwarfs (2 confirmed, 1 new), and a new super-Jupiter mass candidate around V1295 Aql. We searched for correlations between the polarized flux and system parameters, finding a few clear trends: presence of a companion drastically reduces the polarized flux levels, far-IR excess correlates with polarized flux for non-binary systems, and systems hosting disks with ring structures have stellar masses < 3 M . Our sample also included four hot, dusty “FS CMa” systems and we detected large-scale (> 100 au) scattered light around each, signs of extreme youth for these enigmatic systems. Science-ready images are publicly available through multiple distribution channels using a new FITS file standard jointly developed with members of the VLT/SPHERE team.NSFEuropean Research Council (ERC)ANI

Variable effect of co-infection on the HIV infectivity: Within-host dynamics and epidemiological significance

<p>Abstract</p> <p>Background</p> <p>Recent studies have implicated viral characteristics in accounting for the variation in the HIV set-point viral load (spVL) observed among individuals. These studies have suggested that the spVL might be a heritable factor. The spVL, however, is not in an absolute equilibrium state; it is frequently perturbed by immune activations generated by co-infections, resulting in a significant amplification of the HIV viral load (VL). Here, we postulated that if the HIV replication capacity were an important determinant of the spVL, it would also determine the effect of co-infection on the VL. Then, we hypothesized that viral factors contribute to the variation of the effect of co-infection and introduce variation among individuals.</p> <p>Methods</p> <p>We developed a within-host deterministic differential equation model to describe the dynamics of HIV and malaria infections, and evaluated the effect of variations in the viral replicative capacity on the VL burden generated by co-infection. These variations were then evaluated at population level by implementing a between-host model in which the relationship between VL and the probability of HIV transmission per sexual contact was used as the within-host and between-host interface.</p> <p>Results</p> <p>Our within-host results indicated that the combination of parameters generating low spVL were unable to produce a substantial increase in the VL in response to co-infection. Conversely, larger spVL were associated with substantially larger increments in the VL. In accordance, the between-host model indicated that co-infection had a negligible impact in populations where the virus had low replicative capacity, reflected in low spVL. Similarly, the impact of co-infection increased as the spVL of the population increased.</p> <p>Conclusion</p> <p>Our results indicated that variations in the viral replicative capacity would influence the effect of co-infection on the VL. Therefore, viral factors could play an important role driving several virus-related processes such as the increment of the VL induced by co-infections. These results raise the possibility that biological differences could alter the effect of co-infection and underscore the importance of identifying these factors for the implementation of control interventions focused on co-infection.</p