Mathematics as a Supporting Tool for Technological Management

The necessity of production involving the applicability of mathematics in the management decision-making process stimulates the elaboration of this article. This approach seeks to develop under a new profile of Mathematical Science, now as another tool of technological management, while it allows to understand the diverse deductive paradigms of this knowledge of support to the administrative process. In this way, the general objective is to deal with the application of mathematics as a tool in technological management; (1), to evaluate the applicability of these tools in the management of small and medium enterprises (2), to propose a mathematical model that contributes to the innovation of the business enterprise (3). The theoretical foundation is in the Taxonomy of Bloom, prescribed for the development of abilities and cognitive attitudes of the individual. There will be no doubt that mathematical problem-solving procedures advance significantly, especially to the demands of complex solutions. The Content Analysis Method and related procedures apply to this task. As a result .... Therefore, the study of mathematical and statistical application, in addition to computer resources to identify the possible trend in the index of technological management, the present article states that mathematics as a tool has its widespread applicability within the most diverse types of technological management, regardless of their size and showing how mathematics is associated in different areas of knowledge as a trend for technological management, since it is still considered for some as a difficult element among managers

Comunidades de minhocas em solos com diferentes usos no Município da Lapa - Paraná.

5º ELAETAO

Minhocas em sistemas de uso do solo: estudo de caso em Assistência, SP.

Resumo. 5° ELAETAO

Indicadores de qualidade do solo em sistemas de uso do solo: estudo de caso em Assistência, SP.

Resumo. 5° ELAETAO

No evidence for an association between the -36A>C phospholamban gene polymorphism and a worse prognosis in heart failure

Background: In Brazil, heart failure leads to approximately 25,000 deaths per year. Abnormal calcium handling is a hallmark of heart failure and changes in genes encoding for proteins involved in the re-uptake of calcium might harbor mutations leading to inherited cardiomyopathies. Phospholamban (PLN) plays a prime role in cardiac contractility and relaxation and mutations in the gene encoding PLN have been associated with dilated cardiomyopathy. In this study, our objective was to determine the presence of the -36A>C alteration in PLN gene in a Brazilian population of individuals with HF and to test whether this alteration is associated with heart failure or with a worse prognosis of patients with HF. Methods: We genotyped a cohort of 881 patients with HF and 1259 individuals from a cohort of individuals from the general population for the alteration -36A>C in the PLN gene. Allele and genotype frequencies were compared between groups (patients and control). In addition, frequencies or mean values of different phenotypes associated with cardiovascular disease were compared between genotypic groups. Finally, patients were prospectively followed-up for death incidence and genotypes for the -36A>C were compared regarding mortality incidence in HF patients. Results: No significant association was found between the study polymorphism and HF in our population. In addition, no association between PLN -36A>C polymorphism and demographic, clinical and functional characteristics and mortality incidence in this sample of HF patients was observed. Conclusion: Our data do not support a role for the PLN -36A>C alteration in modulating the heart failure phenotype, including its clinical course, in humans

Delimiting the Origin of a B Chromosome by FISH Mapping, Chromosome Painting and DNA Sequence Analysis in Astyanax paranae (Teleostei, Characiformes)

Supernumerary (B) chromosomes have been shown to contain a wide variety of repetitive sequences. For this reason, fluorescent in situ hybridisation (FISH) is a useful tool for ascertaining the origin of these genomic elements, especially when combined with painting from microdissected B chromosomes. In order to investigate the origin of B chromosomes in the fish species Astyanax paranae, these two approaches were used along with PCR amplification of specific DNA sequences obtained from the B chromosomes and its comparison with those residing in the A chromosomes. Remarkably, chromosome painting with the one-arm metacentric B chromosome probe showed hybridization signals on entire B chromosome, while FISH mapping revealed the presence of H1 histone and 18S rDNA genes symmetrically placed in both arms of the B chromosome. These results support the hypothesis that the B chromosome of A. paranae is an isochromosome. Additionally, the chromosome pairs Nos. 2 or 23 are considered the possible B chromosome ancestors since both contain syntenic H1 and 18S rRNA sequences. The analysis of DNA sequence fragments of the histone and rRNA genes obtained from the microdissected B chromosomes showed high similarity with those obtained from 0B individuals, which supports the intraspecific origin of B chromosomes in A. paranae. Finally, the population hereby analysed showed a female-biased B chromosome presence suggesting that B chromosomes in this species could influence sex determinism.This research was funded by grants from the State of São Paulo Research Foundation (FAPESP) to DMZAS (2011/16825-3) and CO (2010/17009-2), grants from National Council for Research and Development (CNPq) to FF and by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)