Streptozotosin ile diyabet oluşturulan ratlarda koenzim q10’un bazı kan antioksidan sistem parametreleri ile pankreas ve aorttaki histolojik değişiklikler üzerine etkileri

The purpose of the present study was to determine the effects of Coenzyme Q10 on antioxidant enzymes in diabetic rats. Group I was not exposed any application. Group II was intraperitoneally administrated 0.3 ml corn oil in daily for four weeks. Group III received 10 mg/kg CoQ10 in 0.3 ml corn oil intraperitoneally daily for four weeks. Diabetes was induced by subcutaneous injections of streptozotocin in group IV. Group V was made diabetic in the same way and then these animals were intraperitoneally injected with 10 mg/kg CoQ10 in 0.3 ml cornoil daily for four weeks. In blood samples, GSH, TBARS, SOD, NO levels and GPx, CAT activities were determined. Pancreas and aorta tissue samples were examined using histological and immunohistochemical methods. Plasma SOD, GPx, CAT and GSH levels in diabetic group were significantly lower than control group. These parameters significantly increased with CoQ10 application to diabetic rats when compared to diabetic group. The increased plasma TBARS level with diabetes reduced with CoQ10 treatment. The histological findings of the study support the changes in enzyme levels as a result of CoQ10 application. In conclusion, CoQ10 application to diabetic rats may have beneficial effects on some negative changes caused by diabetes.Bu çalışmanın amacı diyabet oluşturulan ratlarda koenzim Q10’un antioksidan parametreleri üzerine etkilerini değerlendirmektir. Çalışmada 38 yetişkin, erkek Wistar Abino rat (250-300 gr) kullanıldı. Grup I’deki hayvanlara herhangi bir uygulama yapılmadı. Grup II’deki hayvanlara günde 0.3 ml mısır yağı dört hafta boyunca intraperitoneal olarak uygulandı. Grup III’deki hayvanlara günde 0.3 ml mısır yağında çözdürülen 10 mg/kg CoQ10 dört hafta boyunca intraperitoneal olarak uygulandı. Grup IV’deki hayvanlarda, 40 mg/kg streptozotosinin günde tek doz olmak üzere iki subkutan enjeksiyonu ile diyabet oluşturuldu. Grup V’deki hayvanlarda aynı protokolle diyabet oluşturuldu ve daha sonra bu hayvanlara dört hafta boyunca 0.3 ml mısır yağında çözdürülen 10 mg/kg CoQ10 intraperitoneal olarak uygulandı. Kan örneklerinde GSH, TBARS, SOD, NO seviyeleri ile GPx, CAT aktiviteleri belirlendi. Pankreas ve aorta doku örnekleri histolojik ve immünohistokimyasal yöntemler kullanılarak incelendi. Diyabetik grupta plazma SOD, GPx, CAT ve GSH seviyeleri control grubuna gore önemli oranda düşüktü. Diyabetik ratlara CoQ10 uygulaması ile bu parametreler diyabetik gruba göre önemli oranda arttı. Diyabetle birlikte artan plazma TBARS seviyesi, CoQ10 uygulamasıyla azaldı. Çalışmanın histolojik bulguları CoQ10 uygulaması sonucunda enzim düzeylerindeki değişiklikleri desteklemektedir. Sonuç olarak, diyabetik ratlara CoQ10 uygulaması diyabetin neden olduğu bazı olumsuz değişiklikler üzerine faydalı etkilere sahip olabilir

Evaluation of Semicircular Canal Functions by the Video Head Impulse Test (vHIT) in Individuals with Motion Sickness

Background: In the occurrence of motion sickness, the functioning of the vestibular system in harmony has an important role. Aim/Objective: To evaluate the effectiveness of the vestibular system in individuals with motion disease with the Video Head Impulse Test (vHIT) device, which evaluates the vestibulo-ocular reflex (VOR). Materials and Methods: Thirty individuals with motion sickness (21 females, 9 males) and 30 healthy individuals (11 females, 19 males) without any vestibular complaints were examined with the vHIT device. All participants were older than 18 years. Results: It was observed that VOR gain values of the individuals with motion disease were significantly lower than those of the healthy individuals. Asymmetry values of the individuals with motion disease in all semicircular canals were higher than those of the healthy individuals; however, this difference was statistically significant only in the anterior semicircular canal. Conclusion and Significance: The observation of low gain values in all semicircular canals in individuals with motion sickness suggested that individuals with motion sickness may experience dysfunction in the sensory organelles in the vestibular system. Studies with larger case series and audiological test batteries will help us better understand motion sickness. Keywords: Motion sickness; vestibular; vHIT DOI: 10.7176/JHMN/79-05 Publication date:August 31st 202

Meslek Lisesi Öğrencilerinin Bilişsel ve Duyuşsal Özellikleri

Present research aims to shed light on cognitive and affective features of vocational high school ninth graders by following a phenomenological approach. At the end of a data analysis, the following themes emerged: (a) emotions erupt when faced with failure, (b) undiscovered or undeveloped skills of students, (c) social support in the process of learning, (d) failure to concentrate on the exam, (e) teacher competencies from students’ views, (f) complementary trainings, (g) favored learning strategy, (h) method and techniques of students, (i) the most popular/unpopular lesson, (j) families’ and student’s targets, (k) expectations for the future, (l) distinguished family members as students’ role models, (m) variables impinging on learning motivation, (n) teacher attitudes.Öğrencilerin mevcut potansiyellerinden en iyi şekilde yararlanmalarını sağlamak ve potansiyellerini geliştirmek gerekmektedir. Öğrencilerin sahip olduğu özelliklerine uygun nitelikte verilecek kaliteli bir eğitim başarıyı beraberinde getirecektir. Türkiye’de Fen ve Anadolu liseleri ile kıyaslandığında bazı meslek liselerine merkezi sınavlarda daha düşük puan alan öğrencilerin yerleştiği görülmektedir. Meslek lisesi öğrencileri araştırılması gereken özel bir grubu oluşturmaktadır. Bu araştırmada, meslek lisesi dokuzuncu sınıf öğrencilerinin bilişsel ve duyuşsal özelliklerinin incelenmesi amaçlanmaktadır. Araştırma fenomenolojik yaklaşımla yürütülmüştür. Verilerin analizi sonucu elde edilen temalar şöyledir: Başarısız olunca hissedilen duygular, öğrencilerin keşfedilmemiş, geliştirmedikleri yetenekleri, öğrenme sürecinde sosyal destek, sınava odaklanamama, öğrencilerin değerlendirmelerine göre öğretmen yeterlikleri, tamamlama eğitimleri, öğrencilerin kullandıkları öğrenme strateji, yöntem ve teknikler, matematik; sevilmeyen ve anlaşılmayan ders, Türkçe; en sevilen ders, aile ve öğrencinin hedefleri, geleceğe ilişkin beklentileri: iyi bir meslek sahibi olma, öğrencilerin rol modelleri olarak öne çıkan aile bireyleri, öğrenme motivasyonunu etkileyen değişkenler: okulu bitirmek isteme, hayatını kurtarma isteği, öğretmen tutumları

Marrubium zeydanlii (Lamiaceae), a new species from Turkey

Marrubium zeydanlii (Lamiaceae) is described as a new species from Turkey. It is similar to M. depauperatum and M. sivasense; however, it is distinguished from M. depauperatum by having lanate hairs on the stem, oblanceolate dentate leaves, 4–6-flowered verticillasters. It is also distinguished from M. sivasense by having lanate hairs on the stem, oblanceolate leaves, and shorter petals. The pollen grains are radially symmetrical and isopolar, the shape is oblate-spheroidal with the polar axes 16.7–20 µm and the equatorial axes 17.6–19.3 µm. trnL-F region was used to identify the phylogenetic position of the newly described species. The results of the current study indicated that the new species show significant morphological and molecular differences from closely related species. Taxonomic descriptions and micromorphology of pollen are examined and also, some notes on the ecology, phytogeographic, conservation status, and distribution map of the new species are presented. © TÜBİTAK

Turkish thoracic society early career members task force group’s virtual congress notes: european respiratory society international congress 2020

In this article, Early Career Task Force Group members of the Turkish Thoracic Society summarize the European Respiratory Society 2020 virtual congress. Current developments in the field of respiratory diseases were compiled with the addition of sessions specific to coronavirus disease 2019 this year. Almost all of the congress sessions were examined, and the important and striking results of the congress were highlighted. Congress sessions were attended by expert researchers, and the prominent messages of each session were highlighted in short summaries. They were then grouped under relevant titles and ranked in order of meaning and relation. It was finalized by a team of researchers

Increased mean platelet volume in patients with infective endocarditis and embolic events

Background: Platelet activation appears to play an important role in thromboembolic com­plications of infective endocarditis (IE). Mean platelet volume (MPV) is a potentially useful marker of platelet activity and a quick and easy determinant of thrombotic risk. Hence the aim of this study was to investigate the baseline platelet volume indices (MPV and platelet distribution width [PDW]) in IE patients who developed embolic events in the follow-up period and who did not. Methods: The study group consisted of 76 consecutive patients (female: 55, male: 21, mean age: 26 years old, ranged: 8–64 years) with definite IE according to Duke Criteria. Thirty four healthy subjects, who were age and gender adjusted, served as the control group. The mean duration of hospital stay was 44 days. Results: Among the IE patients, 13 (13/76, 17.1%) had major embolic events. Significantly larger vegetations were observed in patients with embolic events as compared to non-embolic group (1.4 vs. 1.0 cm, p = 0.03). MPV at hospital admission was higher in patients who had embolic events in the follow-up period compared to both those who did not and the control subjects (10.62 ± 1.13 vs. 9.25 ± 0.97 and 8.93 ± 0.82 fL, p < 0.001, respectively). Similarly, the patients with embolic events had increased PDW compared to the non-embolic ones and the control group (16.31 ± 2.42 vs. 14.35 ± 1.97 and 14.04 ± 1.82%, p < 0.001, respectively). Conclusions: The present study demonstrated that IE patients with embolic events had in­creased MPV and PDW values, compared to non-embolics. Future prospective studies with standardized measurements may clarify the clinical role of platelet volume indices in thrombo­embolic complications of IE

Investigation of Effectiveness Studies Conducted by Using Cognitive Behavioral Group Therapy, Psychodrama and Art Therapy in Turkey

The aim of this study was to review the studies conducted in Turkey which evaluated the effectiveness of cognitive behavioral group therapy, psychodrama, and art group therapy programs. Articles only in Turkish that were published between 2000-2018 were searched by using specified keywords in Ebscohost, Ulakbim, DergiPark, Turkish Psychiatry Index, and Google Scholar databases. Among the articles, studies which were not effectiveness studies, those which did not have CBT group therapy, psychodrama, art therapy, those which did not indicate the effectiveness of the therapy, those which were thesis, case reports, studies that using two different group therapies, and psychoeducation and psychological counseling programs were excluded from the review. A total of 27 studies that met the inclusion criteria were included. Studies were examined in terms of research method, samples, therapy characteristics, and obtained results. The results showed that CBT group therapy, psychodrama, and art therapy were effective in alleviating different problems. Examined results suggested that more experimental and effectiveness studies regarding group psychotherapy are neede

ASSOCIATION BETWEEN SLEEP QUALITY AND GERIATRIC SYNDROMES IN NURSING HOME RESIDENTS

Background: With aging, an increase is observed in some geriatric syndromes as well as sleep disorders. Objective: The aim of this study is to investigate the relationship between sleep quality and geriatric syndromes (dementia, depression, sarcopenia, malnutrition, and frailty) in nursing home residents. Methods: The participants’ demographic characteristics, comorbid diseases, number of drugs, cognitive performance, mood and nutritional states, sarcopenia and fraility screening tests and sleep quality test were evaluated by two geriatricians. The participants were divided into two groups as good sleep quality and poor sleep quality. Correlation analysis of sleep quality and geriatric and mental functionality tests was performed with Spearman correlation analysis. Results: A total of 104 nursing home residents (34 females, 74 males, aged 61-98) participated in the study. Sleep quality was found to be worse in the elderly between the ages of 75-84, with a higher number of children, using assistive devices, and taking selective serotonin reuptake inhibitors. In addition, in participants with poor sleep quality, SARC-f (strength, assistance with walking, rising from a chair, climbing stairs, and falls) and geriatric depression scale scores were significantly higher. The Pittsburgh Sleep Quality Index global score was negatively associated with total sleep time and positively associated with geriatric depression scale score and SARC-f score. Conclusion: Findings from the present study in relation between poor sleep quality and some geriatric evaluation parameters suggests that there may be a common pathophysiological alteration with aging

Usporedba kemijskih i bioloških značajki propolisa pčelinje pasmine Apis mellifera caucasica iz turskih provincija Ardahana i Erzuruma

The aim of this study was to compare the biological activities of ethanolic propolis extracts of Apis mellifera caucasica obtained from Ardahan and Erzurum provinces of Turkey. Samples were tested for antioxidant, anticytotoxic, anticarcinogenic, antibacterial, and antifungal potentials using different techniques. Propolis samples from the two provinces had different mineral and organic compositions related to their geographical origin. The ferric reducing antioxidant power (FRAP) test showed superiority of Ardahan propolis over the Erzurum. Regardless of origin and the presence of mitomycin C in the culture medium, propolis enhanced human peripheral lymphocyte viability, which depended on the duration and propolis concentration. Antiperoxidative activity on MCF-7 breast cancer cells was concentrationdependent. Erzurum propolis showed the highest anticarcinogenic activity at the concentrations of 62.5 μg/mL and 125 μg/ mL, which dropped at higher concentrations. All propolis samples also showed antibacterial activity against the tested human pathogens similar to ampicillin and penicillin controls, except for Pseudomonas aeruginosa. However, they did not exert any antifungal activity against Candida albicans and Yarrowia lipolytica. In conclusion, propolis samples from both provinces showed promising biological activities, but further research should focus on finding the right concentrations for optimal effect and include the cell necrosis pathway to get a better idea of the anticarcinogenic effects.Cilj je ovoga istraživanja bio usporediti biološku aktivnost etanolnih ekstrakata propolisa pčelinje pasmine Apis mellifera caucasica iz dviju turskih provincija: Ardahana i Erzuruma. Testirana su njihova antioksidacijska, anticitotoksična, antikancerogena, antibakterijska i antifungalna svojstva. Uzorci iz tih dviju provincija razlikovali su se u mineralnom i organskom sastavu koji je odražavao njihovo zemljopisno podrijetlo. Test redukcije željeza/antioksidacijske snage (engl. ferric reducing antioxidant power, krat. FRAP) otkrio je superiornost ardahanskoga propolisa nad erzurumskim, no bez obzira na podrijetlo i prisutnost mitomicina C u mediju, oba su propolisa povećala vijabilnost ljudskih perifernih limfocita, a učinak je ovisio o koncentraciji i trajanju. Propolis iz Erzuruma iskazao je najveću antikancerogenu aktivnost u koncentracijama od 62,5 i 125 μg/mL, no ona se smanjila s višim koncentracijama. Oba su propolisa također iskazala antibakterijsku aktivnost sličnu ampicilinskoj i penicilinskoj kontroli, osim kad se radilo o bakteriji Pseudomonas aeruginosa. Međutim, oba su zakazala protiv plijesni Candida albicans i Yarrowia lipolytica. Može se zaključiti da uzorci propolisa iz obiju provincija pružaju obećavajuće biološke aktivnosti, no u daljnja istraživanja, koja se trebaju usmjeriti na traženje optimalnih koncentracija za postizanje željenog učinka, treba uključiti i nekrotični put u mehanizmu djelovanja kako bi se stekao bolji uvid u njihovo antikancerogeno djelovanje