Évolutions de la monnaie et du crédit en France en 2008.

Après plusieurs années de croissance soutenue, la contribution française à l’agrégat M3 de la zone euro a ralenti en 2008. La croissance des crédits au secteur privé, principale source de la création de monnaie, s’est modérée en France comme dans le reste de la zone euro.Monnaie, crédits à l’habitat, crédits aux entreprises.

Les crédits aux sociétés non financières en France : évolutions récentes.

Particulièrement soutenue jusqu’à ces derniers mois, la croissance des crédits aux entreprises donne, depuis peu, des signes de modération, dans un contexte de consolidation des bilans bancaires et de dégradation de l’environnement macroéconomique.Crédits aux entreprises, taux débiteurs, réintermédiation, financement des entreprises, conditions du crédit.

Efficient construction of free energy profiles of breathing metal–organic frameworks using advanced molecular dynamics simulations

In order to reliably predict and understand the breathing behavior of highly flexible metal–organic frameworks from thermodynamic considerations, an accurate estimation of the free energy difference between their different metastable states is a prerequisite. Herein, a variety of free energy estimation methods are thoroughly tested for their ability to construct the free energy profile as a function of the unit cell volume of MIL-53(Al). The methods comprise free energy perturbation, thermodynamic integration, umbrella sampling, metadynamics, and variationally enhanced sampling. A series of molecular dynamics simulations have been performed in the frame of each of the five methods to describe structural transformations in flexible materials with the volume as the collective variable, which offers a unique opportunity to assess their computational efficiency. Subsequently, the most efficient method, umbrella sampling, is used to construct an accurate free energy profile at different temperatures for MIL-53(Al) from first principles at the PBE+D3(BJ) level of theory. This study yields insight into the importance of the different aspects such as entropy contributions and anharmonic contributions on the resulting free energy profile. As such, this thorough study provides unparalleled insight in the thermodynamics of the large structural deformations of flexible materials

Évolutions récentes du crédit aux ménages en France.

Les turbulences observées sur les marchés financiers n’ont guère affecté jusqu’à présent la distribution de crédits à l’habitat en France, alors que la demande des ménages a continué de se modérer de manière graduelle.crédits à l’habitat, ménages, endettement, conditions du crédit, taux débiteurs.

An unusual cause of difficult weaning in a patient with newly diagnosed small cell lung cancer

AbstractWe describe a patient with acute respiratory insufficiency and difficult ventilator weaning in the ICU ward, leading to diagnosis of small cell lung cancer with superior vena cava superior syndrome. Bilateral vocal cord paralysis caused his respiratory distress and weaning difficulties. Thyroidectomy and neurological problems (such as Parkinson disease and Guillain Barré syndrome) are more common causes of bilateral vocal cord paralysis. Lung cancer patients are also at risk due to mediastinal invasion. The left recurrent laryngeal nerve is more prone to paralysis because of the typical anatomy. In contrary, bilateral vocal cord paralysis is rare and doesn't result in speech problems but rather breathing difficulties. Tracheostomy is the classic therapy, but laser cordectomy and Botulinum toxin injection in the laryngeal muscles are alternatives

Achievements and state of the art of hydrogen fuelled IC engines after twenty years of research at Ghent University

Paper presented at the 8th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Mauritius, 11-13 July, 2011.Hydrogen could be “the” fuel for the future, not only for fuel cells but certainly for internal combustion engines. The research on hydrogen started at Ghent University in 1990 with the adaptation of a Valmet diesel engine to hydrogen operation (atmospheric, carbureted version) to prove the capability of hydrogen as a fuel for IC engines. Since then several engines were modified for hydrogen use with the state of the art technologies (sequential injection, electronic management units). With European (Craft, Brite) and Belgian grants three buses demonstrated on several levels the application of hydrogen IC engines. At the moment the laboratory test proves an operation with a power output higher than the gasoline engine, with an equal efficiency of the diesel engine and with very low emissions (NOx less than 100 ppm). The interests of the research group of Ghent University was not only for the experimental work, but also the combustion process is simulated (GUEST code). The estimated formula of the laminar flame speed of hydrogen by Verhelst is worldwide used in other research studies. At the moment a doctoral study examines the heat transfer in hydrogen engines, which is so different from the already not very accurate heat transfer models in gasoline and diesel engines. In our laboratory tests, the hydrogen engine is ready for mass production (backfire safe, high power output, high efficiency, very low emissions). But storage on the vehicle recently and infrastructure of the fuel delivery are the bottle-necks for a real implementation of the hydrogen economy. From hydrogen, methanol can be produced on a sustainable way. Methanol is a liquid (no storage problem on het vehicle) and with minor modifications the same infrastructure can be used as for gasoline. Methanol has very good engine characteristics. Will methanol based on hydrogen be then “the” fuel of the future?mp201

Rise time evaluation of the heat flux microsensor (HFM) on a hot-air-gun test rig

Paper presented at the 8th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Mauritius, 11-13 July, 2011.Investigating the heat transfer inside internal combustion engines is key in the search for higher efficiency, higher power output and lower emissions. To understand the process and to validate model predictions, heat flux measurements inside an engine have to be conducted. In previous works, we have always used a commercially available thermopile to measure the heat transfer in a hydrogen combustion engine, but its large dimensions pose concerns about the sensor’s response time. Therefore, measurements have been done on a calibration rig with a hot air flow as heat source. This paper presents a comparison of the rise time of the thermopile with that of an alternative sensor developed for heat transfer measurements in gas turbines. The papers results in an increased confidence in the thermopile sensor, because its response time is at least as good as that of the alternative sensor. The results do show that the reproducibility of the test rig can be improved. Moreover, due to fluctuations in the heat flux level generated by the source, only the order of magnitude of the measured heat flux of two different experiments was comparable. Therefore, a new calibration rig will be developed to improve the reproducibility and to increase stability of the heat flux level of the heat source.mp201

Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease

BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer's disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). RESULTS: Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. CONCLUSIONS: Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.This study was funded by Appel à Projet Interne (API) of the University Hospital of Strasbourg, Alsace Alzheimer 67, Fondation Université de Strasbourg and famille Jean Amrhein, and Projet Hospitalier de Recherche Clinique (PHRC) inter-régional (IDRCB 2012-A00992-41). The work was also supported by the following: the Newcastle Healthcare Charity (BH0070250); Academy of Medical Sciences, Wellcome Trust Starter Grants scheme for Clinical Lecturers (BH090112 to JPT); Wellcome Intermediate Clinical Fellowship (BH083281 to JPT); National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre in Ageing and Chronic Disease and Biomedical Research Unit in Lewy Body Dementia, based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University; NIHR Dementia Biomedical Research Unit at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge