Spatial updating of objects after rotational and translational body movements in virtual environments

Cataloged from PDF version of article.Spatial reasoning in architectural design can be better understood by considering the factors that affect the spatial updating process of the individual in an environment. This study focuses on the issue of spatial updating of viewed and imagined objects after rotational and translational body movements in a virtual environment (VE). Rotational and translational movements based on an egocentric frame of reference where there is no control of the user are compared in a desktop VE. Moreover, preference in architectural drawing medium and gender are analyzed as the factors that affect the spatial updating of objects in each body movement type. The results indicated that translational movement was more efficient than the rotational movement in judgment of relative directions in viewed objects. Furthermore, the viewed objects were more correctly spatially updated than the imagined ones both in translational and rotational body movements. In comparison of hand, computer and both as the drawing media, findings indicated that preference in computer medium in architectural design drawings was an effective one in spatial updating process in a VE. Contrary to the previous studies, it is found that there was no significant difference between gender and movement types. © 2008 Elsevier Ltd. All rights reserved

Implications of strategic alliances for earnings quality and capital market investors

Strategic alliances are well-established organizational forms and a means of strategy implementation. Despite their growing pervasiveness in the economy, existent literature provides few insights about earnings quality of strategic alliances. This challenge is especially severe in contractual alliances (CAs), where firms do not form a new corporate entity that is separate from the parent organization in comparison to joint ventures (JVs). We investigate how earnings attributes differ depending on involvement in strategic alliances of 8137 CAs and 3026 JVs spanning 1997-2007. We find, in particular, that earnings attributes of firms involved in contractual alliances are broadly reflective of low underlying accounting quality. Relative to JV firms and non-alliance (NA) firms, they have higher levels of discretionary accruals, lower accrual quality, and earnings that are less persistent, less smooth, less relevant, less timely, and less conservative. They also have lower earnings response coefficients. © 2013 Elsevier Inc

Determination of Yield and Yield Components of Vetch and Cereal Mixture and Evaluation Using by GGE-Biplot Analysis

This study was carried out to determine forage and seed yield and its effecting component in different vetch and cereal mixtures, ecological condition of Tekirdağ-Thrace region of Turkey. The study was conducted using a total 5 vetch and cereals varieties includes three different vetch species orakefe, Hungarian vetch species sarıefe, narbon vetch candidate variety 570, two different cereals (barley variety scarpia, oat variety sebat) and their mixture combinations, each species were sown as sole, double and triple mixtures (8 combinations for each genotype) a randomized complete block design with 3 replications was laid out on 2013-2015 growing season. Eight mixture combinations for each genotype (common vetch, Hungarian vetch, Narbon vetch, barley and oat) were evaluated for yield and major plant structural characteristics. Genotype-Trait (GT) biplot analyses were used. Applying type of analyses to the multiple trait data revealed that GT biplot graphically displayed the interrelationships among traits and facilitated visual comparison of mixtures and selection for each genotype. Wide variation was observed for traits plant structure and components (plant height, branch number and pod number/plant, 1000 seed weight, individual genotype ratio). It was found that; seed yield, 1000 seed weight, plant height, branch and pod number /plant were the highest value in pure stand NV570. In addition (570+sebat) had maximum dry forage yield, sarıefe as pure stand has the maximum plant height and seed yield value. On the other had sarıefe+scarpia combination showed very high value for pod number/plant, branch number/plant and fresh and dry forage yield. Pure stand scarpia was the best performer in seed yield. CV+NV+scarpia had the highest 1000 seed weight, fresh and dry forage yield. Maximum planth height was determined from sebat+scarpia, CV+O+B and CV+HV+B combinations. Favorable seed yield and 1000 seed weight value was produced under pure stand sebat seeding. Intercrop NV570+O combination had the higher fresh and dry forage yield. CV+HV+O, CV+NV+O and CV+B+O combination had the highest plant height of sebat

Non-kutanöz Periferik T-hücreli Lenfomalarda Klinik Özellikler ve Tedavi Sonuçlarına ilişkin Gerçek Yaşam Deneyimi:Türk Hematoloji Araştırma ve Eğitim Grubunun Çok Merkezli Çalışması

Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event-free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy. © 2022 by Turkish Society of Hematology Turkish Journal of Hematology, Published by Galenos Publishing House

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Background: Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them. Methods: The study was conducted among participants from the Erasmus Rucphen Family Study (ERF), a Dutch family-based sample from the southwestern Netherlands. Variance components linkage analyses were performed using Merlin. Regions of interest (LOD &gt; 1.9) were fine-mapped using microarray and exome sequence data. Results: We observed one significant LOD score for the second principal component on chromosome 15 (LOD score = 3.01) and 12 suggestive LOD scores. Several loci contained variants identified in GWAS for these traits; however, these did not explain the linkage peaks, nor did other common variants. Exome sequence data identified two associated variants after multiple testing corrections were applied. Conclusions: We did not find common SNPs explaining these linkage signals. Exome sequencing uncovered a relatively rare variant in MAPK3K11 on chromosome 11 (MAF = 0.01) that helped account for the suggestive linkage peak observed for the first principal component. Conditional analysis revealed a drop in LOD from 2.01 to 0.88 for MAP3K11, suggesting that this variant may partially explain the linkage signal at this chromosomal location. MAP3K11 is related to the JNK pathway and is a pro-apoptotic kinase that plays an important role in the induction of cardiomyocyte apoptosis in various pathologies, including LVH. © 2018 The Author(s)

A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study

Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies of these phenotypes have been successful in identifying common variants; however, a large proportion of the genetic variability of these traits remains to be elucidated. The aim of this study was to discover loci potentially harboring rare variants utilizing variance component linkage analysis in 1547 individuals from a large family-based study, the Erasmus Rucphen Family Study (ERF). Linked regions were further explored using exome sequencing. Five suggestive linkage peaks were identified: two for QT interval (1q24, LOD = 2.63; 2q34, LOD = 2.05), one for QRS interval (1p35, LOD = 2.52) and two for PR interval (9p22, LOD = 2.20; 14q11, LOD = 2.29). Fine-mapping using exome sequence data identified a C > G missense variant (c.713C > G, p.Ser238Cys) in the FCRL2 gene associated with QT (rs74608430; P = 2.8 x 10(-4), minor allele frequency = 0.019). Heritability analysis demonstrated that the SNP explained 2.42% of the trait's genetic variability in ERF (P = 0.02). Pathway analysis suggested that the gene is involved in cytosolic Ca2+ levels (P = 3.3 x 10(-3)) and AMPK stimulated fatty acid oxidation in muscle (P = 4.1 x 10(-3)). Look-ups in bioinformatics resources showed that expression of FCRL2 is associated with ARHGAP24 and SETBP1 expression. This finding was not replicated in the Rotterdam study. Combining the bioinformatics information with the association and linkage analyses, FCRL2 emerges as a strong candidate gene for QT interval