Ἀλήθεια como desvelamento: Heidegger sobre o conceito de verdade em Platão e consequente crítica

O presente artigo aduz a interpretação de Martin Heidegger do conceito de ἀλήθεια – tradicionalmente traduzido por verdade – na filosofia de Platão, a partir da célebre alegoria da caverna presente na República. Segundo o posicionamento inicial de Heidegger, ἀλήθεια era originalmente pensada pelos gregos como desvelamento até Platão, com quem o sentido do termo se transforma e passa a expressar a retitude da percepção. Contudo, as críticas filológicas proferidas contra Heidegger por Paul Friedländer fizeram com que seu posicionamento histórico-filológico inicial fosse em certa medida alterado, passando a sustentar que os gregos antigos, embora tivessem experimentado o acontecimento original de ἀλήθεια, não foram capazes de expressá-lo como tal. Por conseguinte, Heidegger também abandonou a tese de que houve em Platão uma mudança essencial no sentido de ἀλήθεια

Aproximando-se da distância: as principais disparidades do pensamento fraco de Vattimo ante a ontologia heideggeriana

O presente ensaio pretende apresentar uma série de distanciamentos fundamentais entre o pensamento do italiano Gianni Vattimo, centrado no conceito de pensamento fraco, com a ontologia heideggeriana. A problemática consiste no confesso fato de Vattimo basear seu pensamento na filosofia de Heidegger; contudo, sob forte influência do pensamento de Nietzsche, o filósofo italiano acaba por desvirtuar certos conceitos cruciais da filosofia heideggeriana, conduzindo-a a conclusões diametralmente opostas às suas. Vattimo assevera, assim, que há um elemento niilista que perpassa toda a ontologia heideggeriana, não, contudo, apenas como um sintoma de uma sociedade decadente e indefinida, mas julga esta mesma ausência de sentido como a própria superação da metafísica tão almejada pela filosofia da história de Heidegger

Chronic Lymphocytic Leukemia: Keeping Cell Death at Bay

Chronic lymphocytic leukemia (CLL) is a common adult leukemia caused by abnormal accumulation of B cells. Raval et al. (2007) now implicate dowregulation of the expression of the kinase DAPK1 both genetically and epigenetically in familial and sporadic CLL

The evolution of electrical energy measurement in Brazil

Peer Reviewe

Pulmonary hemorrhage: Imaging with a new magnetic resonance blood pool agent in conjunction with breathheld three-dimensional magnetic resonance angiography

Purpose: To describe the three-dimensional magnetic resonance angiography (3D MRA) imaging appearance of the pulmonary arteries following administration of a superparamagnetic iron oxide blood pool agent to human volunteers, and to demonstrate in an animal model (pigs) how this technique can be used to detect pulmonary parenchymal hemorrhage. Methods: Two volunteers were examined following the intravenous administration of a superparamagnetic iron oxide blood pool agent (NC100150 Injection, Nycomed Amersham Imaging, Wayne, PA, USA). T1-weighted 3D gradient recalled echo (GRE) image sets (TR/TE 5.1/1.4 msec, flip angle 30°) were acquired breathheld over 24 sec. To assess the detectability of pulmonary bleeding with intravascular MR contrast, pulmonary parenchymal injuries were created in two animals under general anesthesia, and fast T1-weighted 3D GRE image sets collected before and after the injury. Results: Administration of the intravascular contrast in the two volunteers resulted in selective enhancement of the pulmonary vasculature permitting complete visualization and excellent delineation of central, segmental, and subsegmental arteries. Following iatrogenic injury in the two animals, pulmonary hemorrhage was readily detected on the 3D image sets. Conclusion: The data presented illustrate that ultrafast 3D GRE MR imaging in conjunction with an intravenously administered intravascular blood pool agent can be used to perform high-quality pulmonary MRA as well as to detect pulmonary hemorrhag

HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

BACKGROUND: HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of homeodomain containing transcription factors. RESULTS AND CONCLUSIONS: We show here that HIPK2 activates transcription mediated by tumor suppressor p53 responsive promoter elements. Overexpression of HIPK2 leads to an increase of p53 protein expression or stability, which becomes enhanced further in the presence of the DNA damaging drug doxorubicin. The effects of HIPK2 on p53 are not observed with kinase deficient HIPK2 mutants. However, HIPK2 is not sufficient for phosphorylation of three crucial serine residues of p53, suggesting that HIPK2-induced p53 activation does not involve phosphorylation of p53. Instead, HIPK2 leads to a downregulation of p53-induced Mdm2 protein and this may lead to stabilization of p53. Overexpression of HIPK2 does not lead to a change of Mdm2 mRNA expression. The data suggest that HIPK2 plays a critical role in p53 mediated cellular responses by removing the p53 inhibitor protein Mdm2 via modification of the protein itself or its intracellular movement

‘Follow the Money’: tracking the diffusion of the American anti-money laundering policy in Latin America (1990s-2000s)

Given the wide reach of transnational crimes and the illegal flow of money, policing at an international level has become a new frontier for authorities who aim to control these threats. The United States has taken the center stage in this effort ever since the proclamation of the war on drugs and the continuing war on terror by promoting the ‘follow the money’ principle as a fundamental strategy to be adopted worldwide. In this paper, we will focus on US efforts to expand the anti-money laundering agenda and policies to Latin America, mobilizing the policy diffusion approach. By incorporating this thinking tool, we also aim to highlight the United States hegemonic position when establishing agendas and priorities internationally. Therefore, we will trace US official documents describing strategies, practices and policies aimed at promoting anti-money laundering policies in Latin American institutions through coercion, competition, learning and emulation mechanisms. By promoting training events and formulating evaluation mechanisms, the US has stimulated Latin American countries to elaborate their own law enforcement efforts inspired by these same paradigms.Given the wide reach of transnational crimes and the illegal flow of money, policing at an international level has become a new frontier for authorities. The United States has taken the center stage in this effort ever since the proclamation of the War on Drugs and the continuing War on Terror by promoting the ‘Follow the Money’ principle as a fundamental strategy to be adopted worldwide. The main goal of this paper is to identify the US efforts to formulate and expand the anti-money laundering agenda and policies to Latin America, from the 1990s to the 2000s, mobilizing the policy diffusion approach. By incorporating this thinking tool, we also aim to highlight the United States hegemonic position when establishing agendas and priorities internationally. Therefore, based on a qualitative design, we trace US official documents describing strategies, practices and policies aimed at promoting anti-money laundering policies in Latin American institutions through coercion, competition, learning and emulation mechanisms. As a result, by promoting training events and formulating evaluation mechanisms, the US has stimulated Latin American countries to elaborate their own law enforcement efforts inspired by these same paradigms, indicating that the US uses these anti-money laundering instruments to promote its policy agenda

In vitro image characteristics of an abdominal aortic stent graft: CTA versus 3D MRA

Percutaneous stent-grafting is increasingly employed as a less invasive alternative to surgery for the treatment of infrarenal abdominal aortic aneurysms. It requires long-term imaging follow-up, to document the structural integrity of the device, to exculude perigraft channels and endograft leakages, as well as the shrinkage of the aneurysmal sac. The expectation of severe stent induced artifacts and safety concerns have prevented 3D MRA from being used. The purpose of this in vitro study was to investigate the imaging characteristics of a bifurcated stent graft with 3D MRA (3D Frourier transform fast spoiled GRE) at 1.5 T in comparison to those of CTA. Measurement of the stent wall thickness and luminal diameter were made on a agar gel embedded stent graft at five locations on both CTA and MRA images. The stent graft was depicted as a dark ring on MR images. Wall thickness measurments at the five locations of the stent graft overestimated the true stent thickness, while luminal diameters were slightly underestimated. Measurement differences between MR and CT were not statistically significant (P=0.67;P=0.85). Artifacts emanating from the platinum markers were considerably less severe on the MR-images. A wider area of signal loss was seen only at the insertion of the iliac stent leg into the aortic stent portion due to the overlap of two radio-opaque platinum markers. 3D MRA images should permit a comprehensive assessment of the arterial lumen, and of perivascular tissue

Verantwortung. Grundbegriffe der Kommunikations- und Medienethik (Teil 3)

Der Begriff der Verantwortung spielt in der allgemeinen wie auch der angewandten Ethik eine zentrale Rolle. Er bezieht sich auf eine der moralischen Grundfragen des menschlichen Lebens, nämlich die Frage, ob die Folgen unseres Handelns als ethisch akzeptabel gelten können.