Human toxocariasis: contribution by Brazilian researchers

In the present paper the main aspects of the natural history of human infection by Toxocara larvae that occasionally result in the occurrence of visceral and/or ocular larva migrans syndrome were reviewed. The contribution by Brazilian researchers was emphasized, especially the staff of the Tropical Medicine Institute of São Paulo (IMT)

Reaction Of Methyl (e)-2-phenyl-1-azirine-3-acrylates With Hydrazines And Amidines. Synthetic And Mechanistic Implications

1-Azirines 2a-b react with hydrazine in methanol to produce hexahydropyrrolo[3,2-c]pyrazol-5-ones 3a-b. The process is suggested to involve intramolecular interception of an unstable 4-aminopyrazoline intermediate resulting from C=N bond cleavage. Reaction of 2a with phenylhydrazine similarly affords 3c. In dimethyl sulfoxide, on the other hand, formamidine, guanidine, and hydrazine afford imidazole 4, pyrimidines 5a-b, amino-s-triazine 6, or triazole 9 as a consequence of C-C bond cleavage in aziridine intermediate 8. The intermediacy of tautomers is proposed to account for the diversity of products in this case. © 1991 American Chemical Society.5617

Floral Resins Of Clusia Spp.: Chemical Composition And Biological Function

The floral resins of five species of Clusia belonging to two taxonomic sections of the genus were investigated. These resins are used by pollinating bees for nest construction. The major components of these resins are polyisoprenylated benzophenones, a class of biologically active compounds. We found clusianone and three hitherto unknown compounds, grandone, nemorosone and hydroxy-nemorosone.373664276430Armbruster, W.S., (1984) Amer. J. Bot., 71, pp. 1149-1160Roubik, D.W., (1989) Ecology and Natural History of Tropical Bees, , Cambrige University Press, N.YGustafson, K.R., Blunt, J.W., Munro, M.H.G., Fuller, R.W., McKee, T.C., Cardelina, J.H., McMahon, J.B., Boyd, M.R., (1992) Tetrahedron, 48, pp. 10093-10102Cerrini, S., Lamba, D., Delle Monache, F., Pinheiro, R.M., (1993) Phytochemistry, 32, pp. 1023-1028Delle Monache, F., Marta, M., Mac-Quhae, M.M., Nicoletti, M., (1984) Gazz. Chim. Ital., 114, pp. 135-137Tomás-Barberán, F.A., Garcia-Viguera, C., Vit-Olivier, P., Ferreres, F., Tomás-Lorente, F., (1993) Phytochemistry, 34, pp. 191-195noteMcCandlish, L.E., Hanson, J.C., Stout, G.H., (1976) Acta Cryst., 32 B, pp. 1793-1801Delle Monache, F., Delle Monache, G., Gacs-Baitz, E., (1991) Phytochemistry, 30, pp. 2003-2005noteBorremans, F., De Potter, M., De Keulteleire, D., (1975) Org. Magn. Res., 7, p. 41

Glucosidic iridoids from Molopanthera paniculata Turcz. (Rubiaceae, Posoquerieae)

One new veratroyl derivative, together with the known iridoids barlerin and shanzhiside methyl ester were isolated from Molopanthera paniculata. The structures of compounds were established by 1D and 2D NMR and HRMS analyses