Auditory neuropathy in a patient exposed to xylene: case report

Objective: To report the case of an adult patient who developed auditory complaints following xylene exposure, and to review the literature on the effects of solvent exposure on hearing.Case report: The patient presented with a gradual deterioration in his ability to hear in difficult acoustic environments and also to hear complex sounds such as music, over a 40-year period. His symptoms began following exposure to the solvent xylene, and in the absence of any other risk factor. Our audiological investigations revealed normal otoacoustic emissions with absent auditory brainstem responses and absent acoustic reflexes in both ears, consistent with a diagnosis of bilateral auditory neuropathy. Central test results were also abnormal, indicating possible involvement of the central auditory pathway.Conclusions: To our knowledge, this is the first report of retrocochlear hearing loss following xylene exposure. The test results may provide some insight into the effect of xylene as an isolated agent on the human auditory pathway

Indirect Signs of the Peccei-Quinn Mechanism

In the Standard Model, the renormalization of the QCD vacuum angle $\theta$ is extremely tiny, and small $\theta$ is technically natural. In the general Standard Model effective field theory (SMEFT), however, $\Delta\theta$ is quadratically divergent, reflecting the fact that new sources of hadronic CP-violation typically produce $\mathcal O(1)$ threshold corrections to $\theta$. The observation of such CP-violating interactions would therefore be in tension with solutions to the strong CP problem in which $\theta=0$ is an ultraviolet boundary condition, pointing to the Peccei-Quinn mechanism as the explanation for why $\theta$ is small in the infrared. We study the quadratic divergences in $\theta$ arising from dimension-6 SMEFT operators and discuss the discovery prospects for these operators at electric dipole moment experiments, the LHC, and future proton-proton colliders.Comment: 27 pages, 3 figures. Comments welcome

Annealing Double-Head: An Architecture for Online Calibration of Deep Neural Networks

Model calibration, which is concerned with how frequently the model predicts correctly, not only plays a vital part in statistical model design, but also has substantial practical applications, such as optimal decision-making in the real world. However, it has been discovered that modern deep neural networks are generally poorly calibrated due to the overestimation (or underestimation) of predictive confidence, which is closely related to overfitting. In this paper, we propose Annealing Double-Head, a simple-to-implement but highly effective architecture for calibrating the DNN during training. To be precise, we construct an additional calibration head-a shallow neural network that typically has one latent layer-on top of the last latent layer in the normal model to map the logits to the aligned confidence. Furthermore, a simple Annealing technique that dynamically scales the logits by calibration head in training procedure is developed to improve its performance. Under both the in-distribution and distributional shift circumstances, we exhaustively evaluate our Annealing Double-Head architecture on multiple pairs of contemporary DNN architectures and vision and speech datasets. We demonstrate that our method achieves state-of-the-art model calibration performance without post-processing while simultaneously providing comparable predictive accuracy in comparison to other recently proposed calibration methods on a range of learning tasks.Comment: Preprint to be submitted. 18 pages, 9 figures, 2 table

Disk-Loss and Disk Renewal Phases in Classical Be Stars II. Detailed Analysis of Spectropolarimetric Data

In Wisniewski et al. 2010, paper I, we analyzed 15 years of spectroscopic and spectropolarimetric data from the Ritter and Pine Bluff Observatories of 2 Be stars, 60 Cygni and {\pi} Aquarii, when a transition from Be to B star occurred. Here we anaylize the intrinsic polarization, where we observe loop-like structures caused by the rise and fall of the polarization Balmer Jump and continuum V-band polarization being mismatched temporally with polarimetric outbursts. We also see polarization angle deviations from the mean, reported in paper I, which may be indicative of warps in the disk, blobs injected at an inclined orbit, or spiral density waves. We show our ongoing efforts to model time dependent behavior of the disk to constrain the phenomena, using 3D Monte Carlo radiative transfer codes.Comment: 2 pages, 6 figures, IAU Symposium 27

A Dynamic Approach to Addressing Observation-Minus-Forecast Mean Differences in a Land Surface Skin Temperature Data Assimilation System

In land data assimilation, bias in the observation-minus-forecast (O-F) residuals is typically removed from the observations prior to assimilation by rescaling the observations to have the same long-term mean (and higher-order moments) as the corresponding model forecasts. Such observation rescaling approaches require a long record of observed and forecast estimates, and an assumption that the O-F mean differences are stationary. A two-stage observation bias and state estimation filter is presented, as an alternative to observation rescaling that does not require a long data record or assume stationary O-F mean differences. The two-stage filter removes dynamic (nonstationary) estimates of the seasonal scale O-F mean difference from the assimilated observations, allowing the assimilation to correct the model for synoptic-scale errors without adverse effects from observation biases. The two-stage filter is demonstrated by assimilating geostationary skin temperature (Tsk) observations into the Catchment land surface model. Global maps of the O-F mean differences are presented, and the two-stage filter is evaluated for one year over the Americas. The two-stage filter effectively removed the Tsk O-F mean differences, for example the GOES-West O-F mean difference at 21:00 UTC was reduced from 5.1 K for a bias-blind assimilation to 0.3 K. Compared to independent in situ and remotely sensed Tsk observations, the two-stage assimilation reduced the unbiased Root Mean Square Difference (ubRMSD) of the modeled Tsk by 10 of the open-loop values

Embedding physical activity guidance during pregnancy and in postpartum care: ‘This Mum Moves’ enhances professional practice of midwives and health visitors

Introduction: The benefits of physical activity during pregnancy and after childbirth are well established, yet many health care professionals do not feel well equipped to provide physical activity guidance to these populations. As such, the objectives of this study were to explore the immediate and longer term effects of training on health care professionals’ ability to provide physical activity guidance to pregnant women and new mothers (mums). Methods: Midwives and health visitors from five locations in the United Kingdom were provided with training on the Chief Medical Officers' physical activity guidelines for pregnancy and after childbirth (n=393). Midwives and health visitors attended training to become This Mum Moves Ambassadors, then disseminated education to colleagues through a cascade training model. Changes in knowledge, confidence, and professional practice were assessed by survey before and immediately after training (n=247), and follow-up surveys were completed 3 (n=35) and 6 (n=34) months post training. Results: At all post training time points, health care professionals reported a significant increase in their confidence to communicate about physical activity (P < .001). The reported frequency of having conversations about physical activity increased significantly 3 and 6 months following training compared to baseline (pregnant women, P = .017; new mums, P = .005). There were changes in the types of advice and resources offered by health care professionals, and an overall increase in health care professionals’ own reported physical activity levels. Discussion: The This Mum Moves cascade approach to delivering training in physical activity guidelines improved reported knowledge, confidence and professional practice of midwives and health visitors, both immediately following and 3 and 6 months after training

Fair exchange in e-commerce and certified e-mail, new scenarios and protocols

We are witnessing a steady growth in the use of Internet in the electronic commerce field. This rise is promoting the migration from traditional processes and applications (paper based) to an electronic model. But the security of electronic transactions continues to pose an impediment to its implementation. Traditionally, most business transactions were conducted in person. Signing a contract required the meeting of all interested parties, the postman delivered certified mail in hand, and when paying for goods or services both customer and provider were present. When all parties are physically present, a transaction does not require a complex protocol. The participants acknowledge the presence of the other parties as assurance that they will receive their parts, whether a signature on a contract, or a receipt, etc. But with e-commerce growing in importance as sales and business channel, all these transactions have moved to its digital counterpart. Therefore we have digital signature of contracts, certified delivery of messages and electronic payment systems. With electronic transactions, the physical presence is not required,moreover, most of the times it is even impossible. The participants in a transaction can be thousands of kilometers away from each other, and they may not even be human participants, they can be machines. Thus, the security that the transaction will be executed without incident is not assured per se, we need additional security measures. To address this problem, fair exchange protocols were developed. In a fair exchange every party involved has an item that wants to exchange, but none of the participants is willing to give his item away unless he has an assurance he will receive the corresponding item from the other participants. Fair exchange has many applications, like digital signature of contracts, where the items to be exchanged are signatures on contracts, certified delivery of messages, where we exchange a message for evidence of receipt, or a payment process, where we exchange a payment (e-cash, e-check, visa, etc.) for digital goods or a receipt. The objective of this dissertation is the study of the fair exchange problem. In particular, it presents two new scenarios for digital contracting, the Atomic Multi- Two Party (AM2P) and the Agent Mediated Scenario (AMS), and proposes one optimistic contract signing protocol for each one. Moreover, it studies the efficiency of Multi-Party Contract Signing (MPCS) protocols from their architecture point of view, presenting a new lower bound for each architecture, in terms of minimum number of transactions needed. Regarding Certified Electronic Mail (CEM), this dissertation presents two optimistic CEMprotocols designed to be deployed on thecurrent e-mail infrastructure, therefore they assume the participation of multiple Mail Transfer Agents (MTAs). In one case, the protocol assumes untrusted MTAs whereas in the other one it assumes each User Agent (UA) trusts his own MTA. Regarding payment systems, this dissertation presents a secure and efficient electronic bearer bank check scheme allowing the electronic checks to be transferred fairly and anonymously.L’ús d’Internet en l’àmbit del comerç electrònic està experimentant un creixement estable. Aquest increment d’ús està promovent lamigració de processos tradicionals i aplicacions (basades en paper) cap a un model electrònic. Però la seguretat de les transaccions electròniques continua impedint la seva implantació. Tradicionalment, la majoria de les transaccions s’han dut a terme en persona. La firma d’un contracte requeria la presència de tots els firmants, el carter entrega les cartes certificades enmà, i quan es paga per un bé o servei ambdós venedor i comprador hi són presents. Quan totes les parts hi són presents, les transaccions no requereixen un protocol complex. Els participants assumeixen la presència de les altres parts com assegurança que rebran el que esperen d’elles, ja sigui la firma d’un contracte, un rebut d’entrega o un pagament. Però amb el creixement del comerç electrònic com a canal de venda i negoci, totes aquestes transaccions s’hanmogut al seu equivalent en el món electrònic. Així doncs tenim firma electrònica de contractes, enviament certificat de missatges, sistemes de pagament electrònic, etc. En les transaccions electròniques la presència física no és necessària, de fet, la majoria de vegades és fins it tot impossible. Els participants poden estar separats permilers de kilòmetres, i no és necessari que siguin humans, podrien sermàquines. Llavors, la seguretat de que la transacció s’executarà correctament no està assegurada per se, necessitem proporcionar mesures de seguretat addicionals. Per solucionar aquest problema, es van desenvolupar els protocols d’intercanvi equitatiu. En un intercanvi equitatiu totes les parts involucrades tenen un objecte que volen intercanviar, però cap de les parts implicades vol donar el seu objecte si no té la seguretat que rebrà els objectes de les altres parts. L’intercanvi equitatiu té multitud d’aplicacions, com la firma electrònica de contractes, on els elements a intercanviar son firmes de contractes, enviament certificat demissatges, on s’intercanvien unmissatge per una evidència de recepció, o un procés de pagament, on intercanviemun pagament (e-cash, visa, e-xec, etc.) per bens digitals o per un rebut. L’objectiu d’aquesta tesi és estudiar el problema de l’intercanvi equitatiu. En particular, la tesi presenta dos nous escenaris per a la firma electrònica de contractes, l’escenari multi-two party atòmic i l’escenari amb agents intermediaris, i proposa un protocol optimista per a cada un d’ells. A més, presenta un estudi de l’eficiència dels protocols de firma electrònica multi-part (Multi-Party Contract Signing (MPCS) protocols) des del punt de vista de la seva arquitectura, presentant una nova fita per a cada una, en termes de mínim nombre de transaccions necessàries. Pel que fa al correu electrònic certificat, aquesta tesi presenta dos protocols optimistes dissenyats per a ser desplegats damunt l’infraestructura actual de correu electrònic, per tant assumeix la participació demúltiples agents de transferència de correu. Un dels protocols assumeix que cap dels agents de transferència de correu participants és de confiança,mentre que l’altre assumeix que cada usuari confia en el seu propi agent. Pel que fa a sistemes de pagament, la tesi presenta un esquema de xec bancari al portador, eficient i segur, que garanteix que la transferència dels xecs es fa demanera anònima i equitativa