Desempenho agro-econômico do feijoeiro comum semeado em duas época da safrinha no médio-norte matogrossense.

Esse trabalho objetivou determinar e analisar os indicadores agro-econômicos de nove cultivares do feijoeiro comum, semeadas na safrinha do ano agrícola de 2010-11 em duas épocas distintas (15/02/2011 e 25/02/2011) dentro do município de Sinop (MT).CONAFE

Desempenho agro-econômico do consórcio entre feijão-comum e Brachiaria ruziziensis implantado simultâneamente na safrinha do médio-norte matogrossense.

Esse trabalho objetivou analisar o desempenho agro-econômico de oito consórcios entre feijão-comum e Brachiaria ruziziensis implantados simultaneamente na safrinha do médio-norte matogrossense, submetidos ou não, á dose reduzida de graminicida.CONAFE

Temozolomide induces apoptosis and senescence in glioma cells cultured as multicellular spheroids

Temozolomide is an alkylating cytostatic drug that finds increasing application in the treatment of melanoma, anaplastic astrocytoma and glioblastoma multiforme. The compound is a prodrug that decomposes spontaneously, independent of an enzymatic activation step. DNA methylation induces futile mismatch repair cycles and depletion of the DNA repair enzyme O6-methylguanine-DNA methyltransferase should then initiate programmed cell death. We show drug-dependent inhibition of tumour growth in a three-dimensional cell culture model of the glioma cell lines U87MG and GaMG. Migrational behaviour of the glioblastoma cells remained unaltered. However, coincubation of tumour spheroids with primary brain aggregates showed reduced tumour cell invasion into brain tissue in the presence of temozolomide. This was not achieved by slowing cellular migration, as temozolomide-treated cells displayed no reduced motility. By transferase-mediated dUTP nick-end labelling (TUNEL) of apoptotic nuclei, we found that the drug was able to induce apoptosis throughout the tumour cell spheroids. Apoptosis was highest in the core region of the spheroids. Repetitive application of sublethal doses of temozolomide to multicellular spheroids resulted in the development of drug resistance in GaMG cells. We suggest that temozolomide is a strong initiator of apoptosis in glioblastoma tumour cells in a spheroid cell culture system, when cells are already in a stressful environment

Crescimento e hematologia do híbrido tambacu (Colossoma macropomum x Piaractus mesopotamicus) cultivado em piscicultura de Macapá, Estado do Amapá.

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Validação de marcadores moleculares para introgressão da característica nervura marrom (bmr6) em linhagens de sorgo biomassa utilizando retrocruzamento assistido.

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Desenvolvimento de híbridos de sorgo sensíveis ao fotoperíodo visando alta produtividade de biomassa.

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Magnetic Resonance Imaging In The Evaluation Of Patients With Aseptic Meningoencephalitis And Connective Tissue Disorders.

To describe the role of magnetic resonance imaging (MRI) in the evaluation of patients with chronic and recurrent aseptic meningitis. A retrospective study of five patients with aseptic meningoencefalitis diagnosed by clinical and CSF findings. CT scans showed without no relevant findings. MRI showed small multifocal lesions hyperintense on T2 weighted images and FLAIR, with mild or no gadolinium enhancement, mainly in periventricular and subcortical regions. Meningoencephalitis preceded the diagnosis of the underlying disease in four patients (Behçet's disease or systemic lupus erythematosus). After the introduction of adequate treatment for the rheumatic disease, they did not present further symptoms of aseptic meningoencephalitis. Aseptic meningoencephalitis can be an early presentation of an autoimmune disease. It is important to emphasize the role of MRI in the diagnosis and follow-up of these patients.5845-5