L’esperienza dei caregiver primari che assistono a domicilio le persone affette dalla Malattia di Alzheimer [Alzheimer's disease and caregivers experience in home care]

The aim of this study is to investigate the experience of primary caregivers (men and women) of Alzheimer Disease dementia, in order to tailor program and project to avoid care giving burden. A qualitative phenomenological method was used and the sample was defined by data saturation. Interviews were carried out and recorded in a day care Centre, transcribed verbatim. The analysis was conducted coding common themes and phrases. Six main themes emerged. Our results are similar to those existing in literature, showing care givers as individual in great danger physically and mentally. In the light of the study it is possible to tailor a nursing model in order to improve quality of life and decrease the burden of caregivers, this model should be implemented and analyzed

Optic radiation tractography and vision in anterior temporal lobe resection.

Anterior temporal lobe resection (ATLR) is an effective treatment for refractory temporal lobe epilepsy but may result in a contralateral superior visual field deficit (VFD) that precludes driving in the seizure-free patient. Diffusion tensor imaging (DTI) tractography can delineate the optic radiation preoperatively and stratify risk. It would be advantageous to incorporate display of tracts into interventional magnetic resonance imaging (MRI) to guide surgery

Design of electron beam bending magnet system for electron and photon therapy: A simulation approach

The doubly achromatic electron beam bending magnet system using two sector magnets has been designed for the medical applications to treat the cancer. The aim of electron beam bending magnet system is to focus an electron beam having a spot size less than 3 mm × 3 mm, energy spread within 3% and divergence angle ≤ 3mrad at the target position. To achieve these parameters, the simulation has been carried out using Lorentz-3EM software. The beam spot, divergence angle and energy spread have been observed with respect to the variation in angles of sector magnets and drift distance. Based on the simulated results, it has been optimized that the first and second magnet has an angle 206° and 35° and the drift distance 80 mm. It is also observed that at the 1125, 1762, 2570, 3265 and 4155 Amp-turn, the optimized design produces 3369, 4972, 6384, 7584 and 9568 Gauss of magnetic field at median plane which require to bend 6, 9, 12, 15 and 18 MeV energy of electron, respectively, for the electron therapy application. The output beam parameters of the optimized design are energy spread ±3%, divergence angle ~3 mrad and spot size 2.6 mm. Moreover, for 6 MV and 15 MV photon therapy applications, an electron beam of energy 6.5 MeV and 15.5 MeV extracted from magnet system and focused on the bremsstrahlung target. Various materials have been studied for photon generation using Monte Carlo based Fluka code and Tungsten material has been optimized as bremsstrahlung target which produces continuous energy bremsstrahlung spectrum. For the photon therapy, the 1233 and 3327 amp-turn, in an optimized design produces 3616 and 7785 Gauss of magnetic field at median plane require to bend 6.5 and 15.5 MeV energy of electron, respectively, which further produces bremsstrahlung radiation from Tungsten target

Sowing times influence canola grain yield and oil quality.

Titulo em português: Influência de épocas de semeadura na produtividade e qualidade de óleo de canola

Eruption dynamics of the 22–23 April 2015 calbuco volcano (Southern Chile): Analyses of tephra fall deposits

After 54 years since its last major eruption in 1961, Calbuco Volcano (Ensenada, Southern Chile) reawakened with few hours of warning on 22 April 2015 at 18:05 local time. The main explosive eruption consisted of two eruption pulses (lasting ~1.5 and 6 h each one) on 22 and 23 April, producing stratospheric (>15 km height) eruption columns. The erupted materials correspond to porphyritic basaltic andesite (~55 wt.% of SiO2). The tephra fall affected mainly the area northeast of the volcano and the finest ash was deposited over Southern Chile and Patagonia Argentina. We studied the tephra fall deposits of both pulses in terms of stratigraphy, distribution, volume, emplacement dynamics and eruption source parameters. Here, we show field observations that have been made 5-470 km downwind and distinguish five layers (Layers A, B, B1, C and D) representing different stages of the eruption evolution: eruption onset (Layer A; pulse 1), followed by the first paroxysmal event (Layer B; pulse 1), in some places interbedded by layer B1, tentatively representing the sedimentation of a secondary plume during the end of pulse 1. We recognized a second paroxysm (Layer C; pulse 2) followed by the waning of the eruption (Layer D; pulse 2). The total calculated bulk tephra fall deposit volume is 0.27 ± 0.007 km3 (0.11-0.13 km3 dense rock equivalent), 38% of which was erupted during the first phase and 62% during the second pulse. This eruption was a magnitude 4.45 event (VEI 4 eruption) of subPlinian type.Fil: Romero, J. E.. Universidad de Atacama; ChileFil: Morgavi, D.. Università di Perugia; ItaliaFil: Arzilli, F.. University of Manchester; Reino UnidoFil: Daga, Romina Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Caselli, Alberto Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Negro; ArgentinaFil: Reckziegel, Florencia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; ArgentinaFil: Viramonte, Jose German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones en Energía no Convencional. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Física. Instituto de Investigaciones en Energía no Convencional; ArgentinaFil: Díaz Alvarado, J.. Universidad de Atacama; ChileFil: Polacci, M.. University of Manchester; Reino UnidoFil: Burton, M.. University of Manchester; Reino UnidoFil: Perugini, D.. Università di Perugia; Itali

Decisional Needs of People From Minority Ethnic Groups Around Living Donor Kidney Transplantation: A UK Healthcare Professionals’ Perspective

Despite improved patient and clinical outcomes, living donor kidney transplantation is underutilized in the United Kingdom, particularly among minority ethnic groups, compared to deceased donor kidney transplantation. This may in part be due to the way in which kidney services present information about treatment options. With a focus on ethnicity, semi structured interviews captured the views of 19 kidney healthcare professionals from two renal centres in West Yorkshire, about the decisional needs and context within which people with advanced kidney disease make transplant decisions. Data were analysed using thematic analysis. Themes were categorized into three groups: 1) Kidney healthcare professionals: language, cultural awareness, trusted personnel, and staff diversity, 2) Patient information resources: timing and setting of education and suitability of patient-facing information and, 3) People with advanced kidney disease: knowledge, risk perception, and cultural/religious beliefs. To our knowledge, this is the first study in the United Kingdom to investigate in depth, healthcare professionals’ views on living donor kidney transplantation decision making. Six recommendations for service improvement/delivery to support decision making around living donor kidney transplantation among minority ethnic groups are described

Optimización de la levadura de fisión Schizosaccharomyces pombe para su uso en la búsqueda de compuestos antitumorales

La desregulación del ciclo celular puede dar lugar a enfermedades como el cáncer. La levadura Schizosaccharomyces pombe es un organismo modelo que puede usarse para el estudio del ciclo celular y la búsqueda de nuevos fármacos antitumorales. Desgraciadamente, los microtúbulos de la levadura no son sensibles a algunas drogas muy utilizadas como el Taxol. El objetivo de este estudio es optimizar a S. pombe para poder expresar en ella tubulinas humanas en lugar de las endógenas así como analizar mediante modelización molecular los cambios necesarios para hacer a S. pombe sensible. De esta forma podríamos utilizar esta levadura para hacer búsquedas masivas de nuevos compuestos anticancerígenos

A Combined EM and Visual Tracking Probabilistic Model for Robust Mosaicking: Application to Fetoscopy

Twin-to-Twin Transfusion Syndrome (TTTS) is a progressive pregnancy complication in which inter-twin vascular connections in the shared placenta result in a blood flow imbalance between the twins. The most effective therapy is to sever these connections by laser photo-coagulation. However, the limited field of view of the fetoscope hinders their identification. A potential solution is to augment the surgeon’s view by creating a mosaic image of the placenta. State-of-the-art mosaicking methods use feature-based ap- proaches, which have three main limitations: (i) they are not robust against corrupt data e.g. blurred frames, (ii) tem- poral information is not used, (iii) the resulting mosaic suf- fers from drift. We introduce a probabilistic temporal model that incorporates electromagnetic and visual tracking data to achieve a robust mosaic with reduced drift. By assuming planarity of the imaged object, the nRT decomposition can be used to parametrize the state vector. Finally, we tackle the non-linear nature of the problem in a numerically stable manner by using the Square Root Unscented Kalman Filter. We show an improvement in performance in terms of robustness as well as a reduction of the drift in comparison to state-of-the-art methods in synthetic, phantom and ex vivo datasets