Mutation of ten-eleven translocation-2 is associated with increased risk of autoimmune disease in patients with myelodysplastic syndrome

Background/Aims: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we investigated whether particular genetic mutations are associated with AID in patients with MDS. Methods: Eighty-eight genetic mutations associated with myeloid malignancy were sequenced in 73 MDS patients. The association between these mutations and AID was then analyzed. Results: The median age of the 73 MDS patients was 70 years (interquartile range, 56 to 75), and 49 (67.1%) were male. AID was observed in 16 of 73 patients (21.9%). Mutations were detected in 57 (78.1%) patients. The percentage (68.8% vs. 80.7%, p = 0.32) and the mean number of mutations (1.8 ± 1.6 vs. 2.2 ± 1.8, p = 0.34) in MDS patients with or without AID were similar. However, the ten-eleven translocation-2 (TET2) mutation rate was significantly higher in patients with AID than in those without (31.3% vs. 5.3%, respectively; p = 0.001). All TET2 mutations were variants of strong clinical significance. Conclusions: Mutation of TET2 in patients with MDS may be associated with increased risk of developing AID.We thank Professor Eun Bong Lee for critical review of the manuscript. This research was supported by Basic Science Research Program through the Nation-al Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1A2A1A17069780)

A simulation study of Top and Bottom Counting Detectors in ISS-CREAM experiment for cosmic ray electron physics

International audienceThe Cosmic Ray Energetics and Mass experiment at the International Space Station (ISS-CREAM) is developed for studying the origin, acceleration and propagation mechanism of high energy cosmic rays. The Top and Bottom Counting Detectors (TCD/BCD), sub-detectors of the ISS-CREAM instrument, are developed for electron/ γ -ray physics. The TCD/BCD help distinguish electrons from protons by comparing the hit and shower width distributions for electrons and protons. The e/p separation capability of the TCD/BCD is studied by using the GEANT3 simulation package, and optimal parameters for the e/p separation are obtained

Karl Brugmann, I pronomi dimostrativi nelle lingue indoeuropee. Un'analisi storico-semantica

traduzione italiana di K. Brugmann, "Die Demonstrativpronomina der indogermanischen Sprachen. Eine bedeutungsgeschichtliche Untersuchung, Vorbemerkungen", Leipzig, 1904, pp. 3-18 e relativa nota introduttiva bio-bibliografica sull'autore a cura del traduttore: Nota su Karl Brugmann, p. 14