691 research outputs found
Vector bundles on the projective line and finite domination of chain complexes
Finitely dominated chain complexes over a Laurent polynomial ring in one
indeterminate are characterised by vanishing of their Novikov homology. We
present an algebro-geometric approach to this result, based on extension of
chain complexes to sheaves on the projective line. We also discuss the
K-theoretical obstruction to extension.Comment: v1: 11 page
Search for exotic baryons in double radiative capture on pionic hydrogen
We report a search for low-lying exotic baryons via double radiative capture
on pionic hydrogen. The data were collected at the TRIUMF cyclotron using the
RMC spectrometer by detecting gamma-ray pairs from pion stops in liquid
hydrogen. No evidence was found to support an earlier claim for exotic baryons
of masses 1004 and 1044 MeV/. We obtain upper limits on the branching
ratios for double radiative capture via these exotic states of and respectively.Comment: 13 pages, 4 figure
Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
Background: The use of tumour xenografts is a well-established research tool in cancer genomics but has not yet
been comprehensively evaluated for cancer epigenomics.
Methods: In this study, we assessed the suitability of patient-derived tumour xenografts (PDXs) for methylome analysis
using Infinium 450 K Beadchips and MeDIP-seq.
Results: Controlled for confounding host (mouse) sequences, comparison of primary PDXs and matching patient
tumours in a rare (osteosarcoma) and common (colon) cancer revealed that an average 2.7% of the assayed CpG sites
undergo major (Δβ ≥ 0.51) methylation changes in a cancer-specific manner as a result of the xenografting procedure.
No significant subsequent methylation changes were observed after a second round of xenografting between primary
and secondary PDXs. Based on computational simulation using publically available methylation data, we additionally
show that future studies comparing two groups of PDXs should use 15 or more samples in each group to minimise
the impact of xenografting-associated changes in methylation on comparison results.
Conclusions: Our results from rare and common cancers indicate that PDXs are a suitable discovery tool for cancer
epigenomics and we provide guidance on how to overcome the observed limitations
Modification of threat-processing in non-anxious individuals: a preliminary, behavioral and ERP study
Background and objectives: Previous research suggests that attention bias toward threat contributes to the development and maintenance of anxiety. The current study extends this work by mapping the neural correlates of experimentally-induced changes in attention bias. The study examines both behavioral and psychophysiological changes associated with experimentally-induced changes in threat bias.
Methods: Thirty-four non-anxious female adults were randomly assigned to one of two conditions: training attention toward threat or placebo control. Attention bias was assessed and trained via a modified dot-probe task. Participants completed pre- and post-training assessments of attention bias and stress reactivity. As well, EEG was collected during pre- and post-test assessment of attention bias using the dot-probe task.
Results: Training induced significant changes in attention bias, though findings were complicated by group differences in baseline threat-bias scores. Compared to controls, those in the training group showed greater depression vulnerability to a post-training stressor and increased P2 amplitude, an ERP component associated with attention toward threat, during the dot-probe task.
Limitations: Although participants were randomly assigned to groups, there were still group differences in pre-training bias scores. Also, while the use of a stress task before the initial assessment of attention bias was used to control for initial differences in stress vulnerability, this may have altered pre-bias scores since participants completed this task immediately after being stressed.
Conclusions: These findings demonstrate training-induced changes in behavior and neural response patterns relevant to work on attention bias modification
Factors Influencing the Participation of Older People in Clinical Trials : Data Analysis from the MAVIS Trial
Peer reviewedPostprin
Metal-insulator transition and charge ordering in the extended Hubbard model at one-quarter filling
We study with exact diagonalization the zero temperature properties of the
quarter-filled extended Hubbard model on a square lattice. We find that
increasing the ratio of the intersite Coulomb repulsion, , to the band width
drives the system from a metal to a charge ordered insulator. The evolution of
the optical conductivity spectrum with increasing is compared to the
observed optical conductivity of several layered molecular crystals with the
theta and beta'' crystal structures.Comment: 5 pages, 3 figure
CDMS, Supersymmetry and Extra Dimensions
The CDMS experiment aims to directly detect massive, cold dark matter
particles originating from the Milky Way halo. Charge and lattice excitations
are detected after a particle scatters in a Ge or Si crystal kept at ~30 mK,
allowing to separate nuclear recoils from the dominating electromagnetic
background. The operation of 12 detectors in the Soudan mine for 75 live days
in 2004 delivered no evidence for a signal, yielding stringent limits on dark
matter candidates from supersymmetry and universal extra dimensions. Thirty Ge
and Si detectors are presently installed in the Soudan cryostat, and operating
at base temperature. The run scheduled to start in 2006 is expected to yield a
one order of magnitude increase in dark matter sensitivity.Comment: To be published in the proceedings of the 7th UCLA symposium on
sources and detection of dark matter and dark energy in the universe, Marina
del Rey, Feb 22-24, 200
Charge ordering and antiferromagnetic exchange in layered molecular crystals of the theta type
We consider the electronic properties of layered molecular crystals of the
type theta-DA, where A is an anion and D is a donor molecule such as
BEDT-TTF [where BEDT-TTF is bis-(ethylenedithia-tetrathiafulvalene)] which is
arranged in the theta type pattern within the layers. We argue that the
simplest strongly correlated electron model that can describe the rich phase
diagram of these materials is the extended Hubbard model on the square lattice
at a quarter filling. In the limit where the Coulomb repulsion on a single site
is large, the nearest-neighbour Coulomb repulsion, V, plays a crucial role.
When V is much larger than the intermolecular hopping integral t the ground
state is an insulator with charge ordering. In this phase antiferromagnetism
arises due to a novel fourth-order superexchange process around a plaquette on
the square lattice. We argue that the charge ordered phase is destroyed below a
critical non-zero value V, of the order of t. Slave boson theory is used to
explicitly demonstrate this for the SU(N) generalisation of the model, in the
large N limit. We also discuss the relevance of the model to the all-organic
family beta''-(BEDT-TTF)SFYSO where Y = CHCF, CH, CHF.Comment: 15 pages, 6 eps figure
Exclusion limits on the WIMP-nucleon cross-section from the Cryogenic Dark Matter Search
The Cryogenic Dark Matter Search (CDMS) employs low-temperature Ge and Si
detectors to search for Weakly Interacting Massive Particles (WIMPs) via their
elastic-scattering interactions with nuclei while discriminating against
interactions of background particles. For recoil energies above 10 keV, events
due to background photons are rejected with >99.9% efficiency, and surface
events are rejected with >95% efficiency. The estimate of the background due to
neutrons is based primarily on the observation of multiple-scatter events that
should all be neutrons. Data selection is determined primarily by examining
calibration data and vetoed events. Resulting efficiencies should be accurate
to about 10%. Results of CDMS data from 1998 and 1999 with a relaxed
fiducial-volume cut (resulting in 15.8 kg-days exposure on Ge) are consistent
with an earlier analysis with a more restrictive fiducial-volume cut.
Twenty-three WIMP candidate events are observed, but these events are
consistent with a background from neutrons in all ways tested. Resulting limits
on the spin-independent WIMP-nucleon elastic-scattering cross-section exclude
unexplored parameter space for WIMPs with masses between 10-70 GeV c^{-2}.
These limits border, but do not exclude, parameter space allowed by
supersymmetry models and accelerator constraints. Results are compatible with
some regions reported as allowed at 3-sigma by the annual-modulation
measurement of the DAMA collaboration. However, under the assumptions of
standard WIMP interactions and a standard halo, the results are incompatible
with the DAMA most likely value at >99.9% CL, and are incompatible with the
model-independent annual-modulation signal of DAMA at 99.99% CL in the
asymptotic limit.Comment: 40 pages, 49 figures (4 in color), submitted to Phys. Rev. D;
v.2:clarified conclusions, added content and references based on referee's
and readers' comments; v.3: clarified introductory sections, added figure
based on referee's comment
Analytical Results for Individual and Group Selection of Any Intensity
The idea of evolutionary game theory is to relate the payoff of a game to reproductive success (= fitness). An underlying assumption in most models is that fitness is a linear function of the payoff. For stochastic evolutionary dynamics in finite populations, this leads to analytical results in the limit of weak selection, where the game has a small effect on overall fitness. But this linear function makes the analysis of strong selection difficult. Here, we show that analytical results can be obtained for any intensity of selection, if fitness is defined as an exponential function of payoff. This approach also works for group selection (= multi-level selection). We discuss the difference between our approach and that of inclusive fitness theory
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