568 research outputs found
From tunneling to photoemission: correlating two spaces
Correlating the data measured by tunneling and photoemission spectroscopies
is a long-standing problem in condensed matter physics. The quasiparticle
interference, recently discovered in high-Tc cuprates, reveals a possibility to
solve this problem. Application of modern phase retrieval algorithms to Fourier
transformed tunneling data allows to recover the distribution of the
quasiparticle spectral weight in the reciprocal space of solids measured
directly by photoemission. This opens a direct way to unify these two powerful
techniques and may help to solve a number of problems related with space/time
inhomogeneities predicted in strongly correlated electron systems.Comment: more info at http://www.imp.kiev.ua/~kord/AC-ARPES/index.htm
Dark Energy and Extending the Geodesic Equations of Motion: Connecting the Galactic and Cosmological Length Scales
Recently, an extension of the geodesic equations of motion using the Dark
Energy length scale was proposed. Here, we apply this extension to the
analyzing the motion of test particles at the galactic scale and longer. A
cosmological check of the extension is made using the observed rotational
velocity curves and core sizes of 1393 spiral galaxies. We derive the density
profile of a model galaxy using this extension, and with it, we calculate
to be ; this is within experimental error of the
WMAP value of . We then calculate to be
kpc, which is in reasonable agreement with observations.Comment: 25 pages. Accepted for publication in General Relativity and
Gravitation. Paper contains the published version of the second half of
arXiv:0711.3124v2 with corrections include
"Dark energy" in the Local Void
The unexpected discovery of the accelerated cosmic expansion in 1998 has
filled the Universe with the embarrassing presence of an unidentified "dark
energy", or cosmological constant, devoid of any physical meaning. While this
standard cosmology seems to work well at the global level, improved knowledge
of the kinematics and other properties of our extragalactic neighborhood
indicates the need for a better theory. We investigate whether the recently
suggested repulsive-gravity scenario can account for some of the features that
are unexplained by the standard model. Through simple dynamical considerations,
we find that the Local Void could host an amount of antimatter
() roughly equivalent to the mass of a typical
supercluster, thus restoring the matter-antimatter symmetry. The antigravity
field produced by this "dark repulsor" can explain the anomalous motion of the
Local Sheet away from the Local Void, as well as several other properties of
nearby galaxies that seem to require void evacuation and structure formation
much faster than expected from the standard model. At the global cosmological
level, gravitational repulsion from antimatter hidden in voids can provide more
than enough potential energy to drive both the cosmic expansion and its
acceleration, with no need for an initial "explosion" and dark energy.
Moreover, the discrete distribution of these dark repulsors, in contrast to the
uniformly permeating dark energy, can also explain dark flows and other
recently observed excessive inhomogeneities and anisotropies of the Universe.Comment: 6 pages, accepted as a Letter to the Editor by Astrophysics and Space
Scienc
Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics
Background: The use of tumour xenografts is a well-established research tool in cancer genomics but has not yet
been comprehensively evaluated for cancer epigenomics.
Methods: In this study, we assessed the suitability of patient-derived tumour xenografts (PDXs) for methylome analysis
using Infinium 450 K Beadchips and MeDIP-seq.
Results: Controlled for confounding host (mouse) sequences, comparison of primary PDXs and matching patient
tumours in a rare (osteosarcoma) and common (colon) cancer revealed that an average 2.7% of the assayed CpG sites
undergo major (Δβ ≥ 0.51) methylation changes in a cancer-specific manner as a result of the xenografting procedure.
No significant subsequent methylation changes were observed after a second round of xenografting between primary
and secondary PDXs. Based on computational simulation using publically available methylation data, we additionally
show that future studies comparing two groups of PDXs should use 15 or more samples in each group to minimise
the impact of xenografting-associated changes in methylation on comparison results.
Conclusions: Our results from rare and common cancers indicate that PDXs are a suitable discovery tool for cancer
epigenomics and we provide guidance on how to overcome the observed limitations
A comparison of infant and toddler feeding practices of mothers with and without histories of eating disorders
This preliminary study surveyed the feeding practices of mothers with eating disorder histories through evaluation of mothers' reported feeding styles, child diet composition and restrictive special approaches to feeding. For this non-randomised cohort study, 25 mothers with eating disorder histories and 25 mothers with no history of an eating disorder with children ages 6-36 months were selected such that the groups were similar based on child age group and child sex. Mothers were compared on self-reported feeding style using the Infant Feeding Styles Questionnaire and on child diet composition and special feeding approaches using a modified version of the Toddler Diet Questionnaire from the Women, Infants, and Children program. Mothers with eating disorder histories scored lower on the restrictive feeding style subscale than controls. No significant differences were detected between groups in child diet including the percentage of mothers who breastfed, duration of breastfeeding, age at solid food introduction, daily number of meals or snacks or daily frequency of consumption of fruits, vegetables or protein foods. Mothers with eating disorder histories were more likely to report taking a restrictive special approach to feeding such as limiting processed foods or feeding organic foods only. Although mothers with eating disorder histories may not differ greatly from control mothers in terms of child diet composition (smaller effects may not have been detected due to limited sample size), they may be more likely to take restrictive special approaches to feeding which mirror dietary rules common in individuals with eating disorders
On the inflationary flow equations
I explore properties of the inflationary flow equations. I show that the flow
equations do not correspond directly to inflationary dynamics. Nevertheless,
they can be used as a rather complicated algorithm for generating inflationary
models. I demonstrate that the flow equations can be solved analytically and
give a closed form solution for the potentials to which flow equation solutions
correspond. I end by considering some simpler algorithms for generating
stochastic sets of slow-roll inflationary models for confrontation with
observational data.Comment: 4 pages RevTeX4 file. Corrected typos in Eqs 11 and 13. Supersedes
journal versio
The fermi arc and fermi pocket in cuprates in a short-range diagonal stripe phase
In this paper we studied the fermi arc and the fermi pocket in cuprates in a
short-range diagonal stripe phase with wave vectors , which
reproduce with a high accuracy the positions and sizes of the fermi arc and
fermi pocket and the superstructure in cuprates observed by Meng et
al\cite{Meng}. The low-energy spectral function indicates that the fermi pocket
results from the main band and the shadow band at the fermi energy. Above the
fermi energy the shadow band gradually departs away from the main band, leaving
a fermi arc. Thus we conclude that the fermi arc and fermi pocket can be fully
attributed to the stripe phase but has nothing to do with pairing.
Incorporating a d-wave pairing potential in the stripe phase the spectral
weight in the antinodal region is removed, leaving a clean fermi pocket in the
nodal region.Comment: 5 pages, 6 figure
Nonthermal atmospheric pressure plasma enhances mouse limb bud survival, growth, and elongation.
The enhanced differentiation of mesenchymal cells into chondrocytes or osteoblasts is of paramount importance in tissue engineering and regenerative therapies. A newly emerging body of evidence demonstrates that appendage regeneration is dependent on reactive oxygen species (ROS) production and signaling. Thus, we hypothesized that mesenchymal cell stimulation by nonthermal (NT)-plasma, which produces and induces ROS, would (1) promote skeletal cell differentiation and (2) limb autopod development. Stimulation with a single treatment of NT-plasma enhanced survival, growth, and elongation of mouse limb autopods in an in vitro organ culture system. Noticeable changes included enhanced development of digit length and definition of digit separation. These changes were coordinated with enhanced Wnt signaling in the distal apical epidermal ridge (AER) and presumptive joint regions. Autopod development continued to advance for approximately 144 h in culture, seemingly overcoming the negative culture environment usually observed in this in vitro system. Real-time quantitative polymerase chain reaction analysis confirmed the up-regulation of chondrogenic transcripts. Mechanistically, NT-plasma increased the number of ROS positive cells in the dorsal epithelium, mesenchyme, and the distal tip of each phalange behind the AER, determined using dihydrorhodamine. The importance of ROS production/signaling during development was further demonstrated by the stunting of digital outgrowth when anti-oxidants were applied. Results of this study show NT-plasma initiated and amplified ROS intracellular signaling to enhance development of the autopod. Parallels between development and regeneration suggest that the potential use of NT-plasma could extend to both tissue engineering and clinical applications to enhance fracture healing, trauma repair, and bone fusion
Axion-like particles as ultra high energy cosmic rays?
If Ultra High Energy Cosmic Rays (UHECRs) with E>4 10^{19} eV originate from
BL Lacertae at cosmological distances as suggested by recent studies, the
absence of the GZK cutoff can not be reconciled with Standard-Model particle
properties. Axions would escape the GZK cutoff, but even the coherent
conversion and back-conversion between photons and axions in large-scale
magnetic fields is not enough to produce the required flux. However, one may
construct models of other novel (pseudo)scalar neutral particles with
properties that would allow for sufficient rates of particle production in the
source and shower production in the atmosphere to explain the observations. As
an explicit example for such particles we consider SUSY models with light
sgoldstinos.Comment: 5 pages, 2 postscript figures, ref. adde
Vortex structure in d-density wave scenario of pseudogap
We investigate the vortex structure assuming the d-density wave scenario of
the pseudogap. We discuss the profiles of the order parameters in the vicinity
of the vortex, effective vortex charge and the local density of states. We find
a pronounced modification of these quantities when compared to a purely
superconducting case. Results have been obtained for a clean system as well as
in the presence of a nonmagnetic impurity. We show that the competition between
superconductivity and the density wave may explain some experimental data
recently obtained for high-temperature superconductors. In particular, we show
that the d-density wave scenario explains the asymmetry of the gap observed in
the vicinity of the vortex core.Comment: 8 pages, 10 figure
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