Early above- and below-ground responses of subboreal conifer seedlings to various levels of deciduous canopy removal

We examined the growth of understory conifers, following partial or complete deciduous canopy removal, in a field study established in two regions in Canada. In central British Columbia, we studied the responses of three species (Pseudotsuga menziesii var. glauca (Beissn.) Franco, Picea glauca (Moench) Voss x Picea engelmannii Parry ex Engelm., and Abies lasiocarpa (Hook.) Nutt.), and in northwestern Quebec, we studied one species (Abies balsamea (L.) Mill.). Stem and root diameter and height growth were measured 5 years before and 3 years after harvesting. Both root and stem diameter growth increased sharply following release but seedlings showed greater root growth, suggesting that in the short term, improvement in soil resource capture and transport, and presumably stability, may be more important than an increase in stem diameter and height growth. Response was strongly size dependent, which appears to reflect greater demand for soil resources as well as higher light levels and greater tree vigour before release for taller individuals. Growth ratios could not explain the faster response generally attributed to true fir species or the unusual swift response of spruces. Good prerelease vigour of spruces, presumably favoured by deciduous canopies, could explain their rapid response to release

Gendering the careers of young professionals: some early findings from a longitudinal study. in Organizing/theorizing: developments in organization theory and practice

Wonders whether companies actually have employees best interests at heart across physical, mental and spiritual spheres. Posits that most organizations ignore their workforce – not even, in many cases, describing workers as assets! Describes many studies to back up this claim in theis work based on the 2002 Employment Research Unit Annual Conference, in Cardiff, Wales

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1

Cathepsins are known to have many important physiological roles and provide a viable target for inhibition. Fluorobenzoyl dipeptide derivatives were synthesized and tested for biological activity in an effort to find an efficient inhibitor of the cysteine protease cathepsin L. Thirty-six novel inhibitors (1-36) were synthesized from protected amino acids via the standard DCC/HOBt coupling protocol, containing a benzyl ester or a nitrile as an electrophilic warhead. The activity of the inhibitors was evaluated against cathepsin L and IC50 values calculated. Modification of both amino acids and terminal groups afforded compounds with single digit micromolar inhibition. Results utilizing the benzoyl-L-leucine-glycine nitrile backbone are comparable to that for the commercially available inhibitor 39. © 2010 Informa UK Ltd

Implementing environmental flows in integrated water resources management and the ecosystem approach

In many of the world’s river basins, the water resources are over-allocated and/or highly modified, access to good quality water is limited or competitive and aquatic ecosystems are degraded. The decline in aquatic ecosystems can impact on human well-being by reducing the ecosystem services provided by healthy rivers, wetlands and floodplains. Basin water resources management requires the determination of water allocation among competing stakeholders including the environment, social needs and economic development. Traditionally, this determination occurred on a volumetric basis to meet basin productivity goals. However, it is difficult to address environmental goals in such a framework, because environmental condition is rarely considered in productivity goals, and short-term variations in river flow may be the most important driver of aquatic ecosystem health. Manipulation of flows to achieve desired outcomes for public supply, food and energy has been implemented for many years. More recently, manipulating flows to achieve ecological outcomes has been proposed. However, the complexity of determining the required flow regimes and the interdependencies between stakeholder outcomes has restricted the implementation of environmental flows as a core component of Integrated Water Resources Management (IWRM). We demonstrate through case studies of the Rhône and Thames river basins in Europe, the Colorado River basin in North America and the Murray-Darling basin in Australia the limitations of traditional environmental flow strategies in integrated water resources management. An alternative ecosystem approach can provide a framework for implementation of environmental flows in basin water resources management, as demonstrated by management of the Pangani River basin in Africa. An ecosystem approach in IWRM leads to management for agreed triple-bottom-line outcomes, rather than productivity or ecological outcomes alone. We recommend that environmental flow management should take on the principles of an ecosystem approach and form an integral part of IWRM

Balancing services from built and natural assets via river basin trade off analysis

Built water infrastructure impacts the balance of services provided by a river and its flow regime. Impacts on both commercial and subsistence activities should be considered in water management decision-making. Various methods used to define mandatory minimum environmental releases do not account for the inherent and often complex trade-offs and synergies which must be considered in selecting a balance of ecosystem and engineered services. This paper demonstrates the value and use of optimised many-objective trade-off analysis for managing resource-systems providing diverse and sometimes competing services. Using Kenya’s Tana River basin as a demonstration it shows controlled releases from multi-reservoir systems can be optimised using multiple performance metrics, representing individual provisioning ecosystem and engineered services at different locations and relating to different time periods. This enables better understanding the interactions between natural and built assets, and selecting river basin interventions that appropriately trade-off their services. Our demonstration shows prioritising Kenya’s statutory minimum environmental ‘reserve’ flows degrades flood-related provisioning services. Low overall flow regime alteration correlates ne