742 research outputs found
Collective effects of stellar winds and unidentified gamma-ray sources
We study collective wind configurations produced by a number of massive stars, and obtain densities and expansion velocities of the stellar wind gas that is to be target, in this model, of hadronic interactions. We study the expected -ray emission from these regions, considering in an approximate way the effect of cosmic ray modulation. We compute secondary particle production (electrons from knock-on interactions and electrons and positrons from charged pion decay), and solve the loss equation with ionization, synchrotron, bremsstrahlung, inverse Compton, and expansion losses. We provide examples where configurations can produce sources for GLAST satellite, and the MAGIC, HESS, or VERITAS telescopes in non-uniform ways, i.e., with or without the corresponding counterparts. We show that in all cases we studied no EGRET source is expected
ATM Mutations and Phenotypes in Ataxia-Telangiectasia Families in the British Isles: Expression of Mutant ATM and the Risk of Leukemia, Lymphoma, and Breast Cancer
SummaryWe report the spectrum of 59 ATM mutations observed in ataxia-telangiectasia (A-T) patients in the British Isles. Of 51 ATM mutations identified in families native to the British Isles, 11 were founder mutations, and 2 of these 11 conferred a milder clinical phenotype with respect to both cerebellar degeneration and cellular features. We report, in two A-T families, an ATM mutation (7271T→G) that may be associated with an increased risk of breast cancer in both homozygotes and heterozygotes (relative risk 12.7; P=.0025), although there is a less severe A-T phenotype in terms of the degree of cerebellar degeneration. This mutation (7271T→G) also allows expression of full-length ATM protein at a level comparable with that in unaffected individuals. In addition, we have studied 18 A-T patients, in 15 families, who developed leukemia, lymphoma, preleukemic T-cell proliferation, or Hodgkin lymphoma, mostly in childhood. A wide variety of ATM mutation types, including missense mutations and in-frame deletions, were seen in these patients. We also show that 25% of all A-T patients carried in-frame deletions or missense mutations, many of which were also associated with expression of mutant ATM protein
Study of Two-Step Mechanisms in Pion Absorption on 6Li, 12C via Deuteron Emission
The (pi+,pd), and (pi+,dd) reactions were investigated with pions of 100 and
165 MeV kinetic energy on 6Li and 12C targets. In comparison with previously
published (pi+,pp) data on the same targets and at the same beam energies,
kinematic regions were identified in which the neutron pickup process n+p->d
dominated the observed deuteron yield. The importance of this mechanism
increases with energy, contributing half of the observed cross section at 165
MeV. The contribution of direct quasi-triton absorption is significant only at
100 MeV.Comment: 23 pages, 12 figure
Statistical Survey of Type III Radio Bursts at Long Wavelengths Observed by the Solar TErrestrial RElations Observatory (STEREO)/Waves Instruments: Radio Flux Density Variations with Frequency
We have performed a statistical study of Type III radio bursts observed
by Solar TErrestrial RElations Observatory (STEREO)/Waves between May 2007 and
February 2013. We have investigated the flux density between kHz and
MHz. Both high- and low-frequency cutoffs have been observed in of
events suggesting an important role of propagation. As already reported by
previous authors, we observed that the maximum flux density occurs at MHz on
both spacecraft. We have developed a simplified analytical model of the flux
density as a function of radial distance and compared it to the STEREO/Waves
data.Comment: published in Solar Physic
Qualitative theory testing as mixed-method research
While the concept of mixed-methods research is more usually associated with combining quantitative and qualitative approaches, this paper outlines a study that mixed methods by undertaking qualitative theory testing and derivation when examining the relationship between health promotion theory and hospital nursing practice. Thus, it is concerned with relating the metatheoretical aspects of the debate and not with the pragmatic aspects of the research and concomitant methods. A deductive–inductive–deductive design, based on the theory–research–theory strategy of Meleis (1985), tested, revised and developed for nursing established health promotion theory using theory-testing criteria. To complement the methodological mix, the study also used the theory (i.e. a health-promotion taxonomy) as a framework to contextualise the findings rather than generate theory in the way associated with interpretative inquiry. While inconsistent with the traditional view linking theory testing with quantitative, objective epistemology, the process enabled a theoretically robust health-promotion taxonomy to be synthesised and advanced for use in nursing in relation to a paradigm of social thought
Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility
We recently reported that a sequence variant in the cell-cycle-checkpoint
kinase CHEK2 (CHEK2 1100delC) is a low-penetrance breast
cancer-susceptibility allele in noncarriers of BRCA1 or BRCA2 mutations.
To investigate whether other CHEK2 variants confer susceptibility to
breast cancer, we screened the full CHEK2 coding sequence in
BRCA1/2-negative breast cancer cases from 89 pedigrees with three or more
cases of breast cancer. We identified one novel germline variant, R117G,
in two separate families. To evaluate the possible association of R117G
and two germline variants repo
Electric current circuits in astrophysics
Cosmic magnetic structures have in common that they are anchored
in a dynamo, that an external driver converts kinetic energy into internal
magnetic energy, that this magnetic energy is transported as Poynting fl ux across the magnetically dominated structure, and that the magnetic energy
is released in the form of particle acceleration, heating, bulk motion,
MHD waves, and radiation. The investigation of the electric current system is
particularly illuminating as to the course of events and the physics involved.
We demonstrate this for the radio pulsar wind, the solar flare, and terrestrial
magnetic storms
Nonperturbative renormalization group approach to frustrated magnets
This article is devoted to the study of the critical properties of classical
XY and Heisenberg frustrated magnets in three dimensions. We first analyze the
experimental and numerical situations. We show that the unusual behaviors
encountered in these systems, typically nonuniversal scaling, are hardly
compatible with the hypothesis of a second order phase transition. We then
review the various perturbative and early nonperturbative approaches used to
investigate these systems. We argue that none of them provides a completely
satisfactory description of the three-dimensional critical behavior. We then
recall the principles of the nonperturbative approach - the effective average
action method - that we have used to investigate the physics of frustrated
magnets. First, we recall the treatment of the unfrustrated - O(N) - case with
this method. This allows to introduce its technical aspects. Then, we show how
this method unables to clarify most of the problems encountered in the previous
theoretical descriptions of frustrated magnets. Firstly, we get an explanation
of the long-standing mismatch between different perturbative approaches which
consists in a nonperturbative mechanism of annihilation of fixed points between
two and three dimensions. Secondly, we get a coherent picture of the physics of
frustrated magnets in qualitative and (semi-) quantitative agreement with the
numerical and experimental results. The central feature that emerges from our
approach is the existence of scaling behaviors without fixed or pseudo-fixed
point and that relies on a slowing-down of the renormalization group flow in a
whole region in the coupling constants space. This phenomenon allows to explain
the occurence of generic weak first order behaviors and to understand the
absence of universality in the critical behavior of frustrated magnets.Comment: 58 pages, 15 PS figure
Gamma rays from colliding winds of massive stars
Colliding winds of massive binaries have long been considered as potential sites of non-thermal high-energy photon production. This is motivated by the detection of non-thermal spectra in the radio band, as well as by correlation studies of yet unidentified EGRET gamma-ray sources with source populations appearing in star formation regions. This work re-considers the basic radiative processes and its properties that lead to high energy photon production in long-period massive star systems. We show that Klein-Nishina effects as well as the anisotropic nature of the inverse Compton scattering, the dominating leptonic emission process, likely yield spectral and variability signatures in the gamma-ray domain at or above the sensitivity of current or upcoming gamma ray instruments like GLAST-LAT. In addition to all relevant radiative losses, we include propagation (such as convection in the stellar wind) as well as photon absorption effects, which a priori can not be neglected. The calculations are applied to WR140 and WR147, and predictions for their detectability in the gamma-ray regime are provided. Physically similar specimen of their kind like WR146, WR137, WR138, WR112 and WR125 may be regarded as candidate sources at GeV energies for near-future gamma-ray experiments. Finally, we discuss several aspects relevant for eventually identifying this source class as a gamma-ray emitting population. Thereby we utilize our findings on the expected radiative behavior of typical colliding wind binaries in the gamma-ray regime as well as its expected spatial distribution on the gamma-ray sky
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