260 research outputs found
Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins
Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively towards the plus end of microtubules, Within the family of conventional kinesins, two groups can be distinguished to date, one derived from animal species, and one originating from filamentous fungi. So far no conventional kinesin has been reported from plant cells. Fungal and animal conventional kinesins differ in several respects, both in terms of their primary sequence and their physiological properties. Thus all fungal conventional kinesins move at velocities that are 4-5 times higher than those of animal conventional kinesins, and all of them appear to lack associated light chains. Both groups of motors are characterized by a number of group-specific sequence features which are considered here with respect to their functional importance. Animal and fungal conventional kinesins also share a number of sequence characteristics which point to common principles of motor function. The overall domain organization is remarkably similar. A C-terminal sequence motif common to all kinesins, which constitutes the only region of high homology outside the motor domain, suggests common principles of cargo association in both groups of motors. Consideration of the differences of, and similarities between, fungal and animal kinesins offers novel possibilities for experimentation (e.g., by constructing chimeras) that can be expected to contribute to our understanding of motor function
Non-Markovian control of qubit thermodynamics by frequent quantum measurements
We explore the effects of frequent, impulsive quantum nondemolition
measurements of the energy of two-level systems (TLS), alias qubits, in contact
with a thermal bath. The resulting entropy and temperature of both the system
and the bath are found to be completely determined by the measurement rate, and
unrelated to what is expected by standard thermodynamical rules that hold for
Markovian baths. These anomalies allow for very fast control of heating,
cooling and state-purification (entropy reduction) of qubits, much sooner than
their thermal equilibration time.Comment: 8 pages, 9 figure
Pseudo Goldstone Bosons Phenomenology in Minimal Walking Technicolor
We construct the non-linear realized Lagrangian for the Goldstone Bosons
associated to the breaking pattern of SU(4) to SO(4). This pattern is expected
to occur in any Technicolor extension of the standard model featuring two Dirac
fermions transforming according to real representations of the underlying gauge
group. We concentrate on the Minimal Walking Technicolor quantum number
assignments with respect to the standard model symmetries. We demonstrate that
for, any choice of the quantum numbers, consistent with gauge and Witten
anomalies the spectrum of the pseudo Goldstone Bosons contains electrically
doubly charged states which can be discovered at the Large Hadron Collider.Comment: 25 pages, 5 figure
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS
Electroweak symmetry breaking in other terms
We analyse descriptions of electroweak symmetry breaking in terms of
ultralocal antisymmetric tensor fields and gauge-singlet geometric variables,
respectively; in particular, the Weinberg--Salam model and, ultimately,
dynamical electroweak symmetry breaking by technicolour theories with enhanced
symmetry groups. Our motivation is to unveil the manifestly gauge invariant
structure of the different realisations. We find, for example, parallels to
different types of torsion.Comment: 15p
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Observation of hard scattering in photoproduction events with a large rapidity gap at HERA
Events with a large rapidity gap and total transverse energy greater than 5
GeV have been observed in quasi-real photoproduction at HERA with the ZEUS
detector. The distribution of these events as a function of the
centre of mass energy is consistent with diffractive scattering. For total
transverse energies above 12 GeV, the hadronic final states show predominantly
a two-jet structure with each jet having a transverse energy greater than 4
GeV. For the two-jet events, little energy flow is found outside the jets. This
observation is consistent with the hard scattering of a quasi-real photon with
a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil
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