257 research outputs found
COVID-19 vaccination in athletes: ready, set, go…
In the fight against the COVID-19 global pandemic, the focus in 2021 has fortunately turned to vaccination strategies. The successful development of several vaccines, and their proven efficacy and short-term safety in large scale multinational trials against severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), offers promise in controlling the pandemic. Many countries are now operationalising their vaccination programmes, and prioritising health-care workers and the most vulnerable individuals within the population—eg, the elderly and those with chronic health conditions.https://www.thelancet.com/journals/lanreshj2022Sports Medicin
COVID-19 vaccination in athletes: ready, set, go…
In the fight against the COVID-19 global pandemic, the focus in 2021 has fortunately turned to vaccination strategies. The successful development of several vaccines, and their proven efficacy and short-term safety in large scale multinational trials against severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), offers promise in controlling the pandemic. Many countries are now operationalising their vaccination programmes, and prioritising health-care workers and the most vulnerable individuals within the population—eg, the elderly and those with chronic health conditions.https://www.thelancet.com/journals/lanreshj2022Sports Medicin
Utilization of COVID-19 Treatments and Clinical Outcomes among Patients with Cancer: A COVID-19 and Cancer Consortium (CCC19) Cohort Study.
Among 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. Logistic regression with multiple adjustments (e.g., comorbidities, cancer status, baseline COVID-19 severity) was performed. Hydroxychloroquine with any other drug was associated with increased mortality versus treatment with any COVID-19 treatment other than hydroxychloroquine or untreated controls; this association was not present with hydroxychloroquine alone. Remdesivir had numerically reduced mortality versus untreated controls that did not reach statistical significance. Baseline COVID-19 severity was strongly associated with receipt of any treatment. Black patients were approximately half as likely to receive remdesivir as white patients. Although observational studies can be limited by potential unmeasured confounding, our findings add to the emerging understanding of patterns of care for patients with cancer and COVID-19 and support evaluation of emerging treatments through inclusive prospective controlled trials. SIGNIFICANCE: Evaluating the potential role of COVID-19 treatments in patients with cancer in a large observational study, there was no statistically significant 30-day all-cause mortality benefit with hydroxychloroquine or high-dose corticosteroids alone or in combination; remdesivir showed potential benefit. Treatment receipt reflects clinical decision-making and suggests disparities in medication access.This article is highlighted in the In This Issue feature, p. 1426
Ultrafast carrier relaxation and vertical-transport phenomena in semiconductor superlattices: A Monte Carlo analysis
The ultrafast dynamics of photoexcited carriers in semiconductor superlattices is studied theoretically on the basis of a Monte Carlo solution of the coupled Boltzmann transport equations for electrons and holes. The approach allows a kinetic description of the relevant interaction mechanisms such as intra- miniband and interminiband carrier-phonon scattering processes. The energy relaxation of photoexcited carriers, as well as their vertical transport, is investigated in detail. The effects of the multiminiband nature of the superlattice spectrum on the energy relaxation process are discussed with particular emphasis on the presence of Bloch oscillations induced by an external electric field. The analysis is performed for different superlattice structures and excitation conditions. It shows the dominant role of carrier-polar-optical-phonon interaction in determining the nature of the carrier dynamics in the low-density limit. In particular, the miniband width, compared to the phonon energy, turns out to be a relevant quantity in predicting the existence of Bloch oscillations
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Observation of hard scattering in photoproduction events with a large rapidity gap at HERA
Events with a large rapidity gap and total transverse energy greater than 5
GeV have been observed in quasi-real photoproduction at HERA with the ZEUS
detector. The distribution of these events as a function of the
centre of mass energy is consistent with diffractive scattering. For total
transverse energies above 12 GeV, the hadronic final states show predominantly
a two-jet structure with each jet having a transverse energy greater than 4
GeV. For the two-jet events, little energy flow is found outside the jets. This
observation is consistent with the hard scattering of a quasi-real photon with
a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil
Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia:a Multinational Point Prevalence Study of Hospitalised Patients
Pseudornonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP.
We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP.
The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low.
The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients
Search for the Chiral Magnetic Effect in Au+Au collisions at GeV with the STAR forward Event Plane Detectors
A decisive experimental test of the Chiral Magnetic Effect (CME) is
considered one of the major scientific goals at the Relativistic Heavy-Ion
Collider (RHIC) towards understanding the nontrivial topological fluctuations
of the Quantum Chromodynamics vacuum. In heavy-ion collisions, the CME is
expected to result in a charge separation phenomenon across the reaction plane,
whose strength could be strongly energy dependent. The previous CME searches
have been focused on top RHIC energy collisions. In this Letter, we present a
low energy search for the CME in Au+Au collisions at
GeV. We measure elliptic flow scaled charge-dependent correlators relative to
the event planes that are defined at both mid-rapidity and at
forward rapidity . We compare the results based on the
directed flow plane () at forward rapidity and the elliptic flow plane
() at both central and forward rapidity. The CME scenario is expected
to result in a larger correlation relative to than to , while
a flow driven background scenario would lead to a consistent result for both
event planes[1,2]. In 10-50\% centrality, results using three different event
planes are found to be consistent within experimental uncertainties, suggesting
a flow driven background scenario dominating the measurement. We obtain an
upper limit on the deviation from a flow driven background scenario at the 95\%
confidence level. This work opens up a possible road map towards future CME
search with the high statistics data from the RHIC Beam Energy Scan Phase-II.Comment: main: 8 pages, 5 figures; supplementary material: 2 pages, 1 figur
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