Five-Torsion in the Homology of the Matching Complex on 14 Vertices

J. L. Andersen proved that there is 5-torsion in the bottom nonvanishing homology group of the simplicial complex of graphs of degree at most two on seven vertices. We use this result to demonstrate that there is 5-torsion also in the bottom nonvanishing homology group of the matching complex $M_{14}$ on 14 vertices. Combining our observation with results due to Bouc and to Shareshian and Wachs, we conclude that the case $n=14$ is exceptional; for all other $n$, the torsion subgroup of the bottom nonvanishing homology group has exponent three or is zero. The possibility remains that there is other torsion than 3-torsion in higher-degree homology groups of $M_n$ when $n \ge 13$ and $n \neq 14$.Comment: 11 page

Subthreshold dynamics of the neural membrane potential driven by stochastic synaptic input

In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of the background activity and of the synapses made on a neuron. Subthreshold membrane polarization is, in turn, a potent modulator of neural responses. The present paper analyzes the subthreshold dynamics of the neural membrane potential driven by synaptic inputs of stationary statistics. Synaptic inputs are considered in linear interaction. The analysis identifies regimes of input statistics which give rise to stationary, fluctuating, oscillatory, and unstable dynamics. In particular, I show that (i) mere noise inputs can drive the membrane potential into sustained, quasiperiodic oscillations (noise-driven oscillations), in the absence of a stimulus-derived, intraneural, or network pacemaker; (ii) adding hyperpolarizing to depolarizing synaptic input can increase neural activity (hyperpolarization-induced activity), in the absence of hyperpolarization-activated currents

The Dirac system on the Anti-de Sitter Universe

We investigate the global solutions of the Dirac equation on the Anti-de-Sitter Universe. Since this space is not globally hyperbolic, the Cauchy problem is not, {\it a priori}, well-posed. Nevertheless we can prove that there exists unitary dynamics, but its uniqueness crucially depends on the ratio beween the mass $M$ of the field and the cosmological constant $\Lambda>0$ : it appears a critical value, $\Lambda/12$, which plays a role similar to the Breitenlohner-Freedman bound for the scalar fields. When $M^2\geq \Lambda/12$ there exists a unique unitary dynamics. In opposite, for the light fermions satisfying $M^2<\Lambda/12$, we construct several asymptotic conditions at infinity, such that the problem becomes well-posed. In all the cases, the spectrum of the hamiltonian is discrete. We also prove a result of equipartition of the energy.Comment: 33 page

An optimal gap theorem

By solving the Cauchy problem for the Hodge-Laplace heat equation for $d$-closed, positive $(1, 1)$-forms, we prove an optimal gap theorem for K\"ahler manifolds with nonnegative bisectional curvature which asserts that the manifold is flat if the average of the scalar curvature over balls of radius $r$ centered at any fixed point $o$ is a function of $o(r^{-2})$. Furthermore via a relative monotonicity estimate we obtain a stronger statement, namely a `positive mass' type result, asserting that if $(M, g)$ is not flat, then $\liminf_{r\to \infty} \frac{r^2}{V_o(r)}\int_{B_o(r)}\mathcal{S}(y)\, d\mu(y)>0$ for any $o\in M$

Antiflow of kaons in relativistic heavy ion collisions

We compare relativistic transport model calculations to recent data on the sideward flow of neutral strange K^0_s mesons for Au+Au collisions at 6 AGeV. A soft nuclear equation of state is found to describe very well the positive proton flow data measured in the same experiment. In the absence of kaon potential, the K^0 flow pattern is similar to that of protons. The kaon flow becomes negative if a repulsive kaon potential determined from the impulse approximation is introduced. However, this potential underestimates the data which exhibits larger antiflow. An excellent agreement with the data is obtained when a relativistic scalar-vector kaon potential, that has stronger density dependence, is used. We further find that the transverse momentum dependence of directed and elliptic flow is quite sensitive to the kaon potential in dense matter.Comment: 5 pages, Revtex, 4 figure

Density dependent hadron field theory for neutron stars with antikaon condensates

We investigate $K^-$ and $\bar K^0$ condensation in $\beta$-equilibrated hyperonic matter within a density dependent hadron field theoretical model. In this model, baryon-baryon and (anti)kaon-baryon interactions are mediated by the exchange of mesons. Density dependent meson-baryon coupling constants are obtained from microscopic Dirac Brueckner calculations using Groningen and Bonn A nucleon-nucleon potential. It is found that the threshold of antikaon condensation is not only sensitive to the equation of state but also to antikaon optical potential depth. Only for large values of antikaon optical potential depth, $K^-$ condensation sets in even in the presence of negatively charged hyperons. The threshold of $\bar K^0$ condensation is always reached after $K^-$ condensation. Antikaon condensation makes the equation of state softer thus resulting in smaller maximum mass stars compared with the case without any condensate.Comment: 20 pages, 7 figures; final version to appear in Physical Review

Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States

Von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of much debate. In order to study the spectrum of type 1 VWD in the United States, the Zimmerman Program enrolled 482 subjects with a previous diagnosis of type 1 VWD without stringent laboratory diagnostic criteria. VWF laboratory testing and full length VWF gene sequencing were performed for all index cases and healthy control subjects in a central laboratory. Bleeding phenotype was characterized using the ISTH Bleeding Assessment Tool. At study entry, 64% of subjects had VWF:Ag or VWF:RCo below the lower limit of normal, while 36% had normal VWF levels. VWF sequence variations were most frequent in subjects with VWF:Ag < 30 IU/dL (82%) while subjects with type 1 VWD and VWF:Ag ≥ 30 IU/dL had an intermediate frequency of variants (44%). Subjects whose VWF testing was normal at study entry had a similar rate of sequence variations as the healthy controls at 14% of subjects. All subjects with severe type 1 VWD and VWF:Ag ≤ 5 IU/dL had an abnormal bleeding score, but otherwise bleeding score did not correlate with VWF:Ag level. Subjects with a historical diagnosis of type 1 VWD had similar rates of abnormal bleeding scores compared to subjects with low VWF levels at study entry. Type 1 VWD in the United States is highly variable, and bleeding symptoms are frequent in this population

MultiCellDS : a community-developed standard for curating microenvironment-dependent multicellular data

Exchanging and understanding scientific data and their context represents a significant barrier to advancing research, especially with respect to information siloing. Maintaining information provenance and providing data curation and quality control help overcome common concerns and barriers to the effective sharing of scientific data. To address these problems in and the unique challenges of multicellular systems, we assembled a panel composed of investigators from several disciplines to create the MultiCellular Data Standard (MultiCellDS) with a use-case driven development process. The standard includes (1) digital cell lines, which are analogous to traditional biological cell lines, to record metadata, cellular microenvironment, and cellular phenotype variables of a biological cell line, (2) digital snapshots to consistently record simulation, experimental, and clinical data for multicellular systems, and (3) collections that can logically group digital cell lines and snapshots. We have created a MultiCellular DataBase (MultiCellDB) to store digital snapshots and the 200+ digital cell lines we have generated. MultiCellDS, by having a fixed standard, enables discoverability, extensibility, maintainability, searchability, and sustainability of data, creating biological applicability and clinical utility that permits us to identify upcoming challenges to uplift biology and strategies and therapies for improving human health

Antikaon condensation and the metastability of protoneutron stars

We investigate the condensation of $\bar K^0$ meson along with $K^-$ condensation in the neutrino trapped matter with and without hyperons. Calculations are performed in the relativistic mean field models in which both the baryon-baryon and (anti)kaon-baryon interactions are mediated by meson exchange. In the neutrino trapped matter relevant to protoneutron stars, the critical density of $K^-$ condensation is shifted considerably to higher density whereas that of $\bar K^0$ condensation is shifted slightly to higher density with respect to that of the neutrino free case. The onset of $K^-$ condensation always occurs earlier than that of $\bar K^0$ condensation. A significant region of maximum mass protoneutron stars is found to contain $\bar K^0$ condensate for larger values of the antikaon potential. With the appearance of $\bar K^0$ condensation, there is a region of symmetric nuclear matter in the inner core of a protoneutron star. It is found that the maximum mass of a protoneutron star containing $K^-$ and $\bar K^0$ condensate is greater than that of the corresponding neutron star. We revisit the implication of this scenario in the context of the metastability of protoneutron stars and their evolution to low mass black holes.Comment: 26 pages; Revtex; 8 figures include