1,251 research outputs found

    Empowering users to control their privacy in context-aware system through interactive consent

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    Context-aware systems adapt their behaviour based on the context a user is in. Since context is potentially privacy sensitive information, users should be empowered to control how much of their context they are willing to share, under what conditions and for what purpose. We propose an interactive consent mechanism that allows this. It is interactive in the sense that users are asked for consent when a request for their context information is received. Our interactive consent mechanism complements a more traditional pre-configuration approach. We describe the architecture, the implementation of our interactive consent mechanism and a use case

    Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML

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    Abstract Between 1985 and 1989, many cases of Philadelphia (Ph) chromosome negative chronic myelogenous leukemia (CML) were reported. For this review, the following selection criteria were used: the original articles on Ph-negative cases should provide clinical, hematologic, cytogenetic as well as molecular data. In addition, eight unpublished cases of Ph-negative CML are included that were studied in our institute during the last two years. Our purpose was to correlate presence or absence of the Ph rearrangement with the clinical features in an attempt to test whether the entity “Ph-negative CML” really exists and to identify the pathologic characteristics, frequency of occurrence, prognosis for survival, and underlying molecular mechanisms. Data on Ph-negative CML patients were compared with data on Ph-positive CML, atypical CML (aCML), and chronic myelomonocytic leukemia (CMMoL), reported in the same papers as the Ph negative patients. Essential for comparison of data from the different investigators appeared to be a clear description of criteria they used to establish the diagnosis CML, or alternatively a complete presentation of data for all patients reported in the articles. In most cases. Ph-negative CML was distinguishable from CMMoL and aCML, using simple criteria, e.g., differential count of peripheral blood and absence of dysplasia in the bone marrow. Cytogenetic analysis showed normal karyotype in most cases of Ph-negative CML. Interestingly, in cases with abnormal karyotype, chromosome 9 band q34 was relatively frequently involved in translocations with other chromosomes than chromosome 22, suggesting a variant Ph translocation not visible by cytogenetic techniques. This assumption was confirmed by molecular analysis, demonstrating bcr-abl rearrangement in 9 out of 10 of the latter cases. Results of cytogenetic and molecular investigations in 136 cases of Ph-negative CML reviewed in this article clearly indicated that molecular techniques are valuable tools for identification of bcr-abl rearrangements, indicative for the Ph translocation. The different mechanisms responsible for bcr-abl rearrangement in Ph-negative CML patients are discussed. The question remains whether all Ph-negative CML patients will have bcr-abl rearrangements, or whether alternative mechanisms will be identified that are responsible for this disease

    An Inner Gaseous Disk around the Herbig Be Star MWC 147

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    We present high-spectral-resolution, optical spectra of the Herbig Be star MWC 147, in which we spectrally resolve several emission lines, including the [O I] lines at 6300 and 6363\deg. Their highly symmetric, double-peaked line profiles indicate that the emission originates in a rotating circumstellar disk. We deconvolve the Doppler-broadened [O I] emission lines to obtain a measure of emission as a function of distance from the central star. The resulting radial surface brightness profiles are in agreement with a disk structure consisting of a flat, inner, gaseous disk and a flared, outer, dust disk. The transition between these components at 2 to 3 AU corresponds to the estimated dust sublimation radius. The width of the double-peaked Mg II line at 4481\deg suggests that the inner disk extends to at least 0.10 AU, close to the corotation radius.Comment: accepted for ApJ Letters (Oct. 2010

    In Conversation with Mubin Shaikh: From Salafi Jihadist to Undercover Agent inside the "Toronto 18" Terrorist Group

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    This interview with former undercover agent Mubin Shaikh can help academics and security practitioners understand the key role played and the challenges faced by covert human intelligence sources within domestic terrorist groups. The interview highlights the identity crisis, the personal factors, and the allure of jihadi militancy that initially drove Shaikh to join a Salafi jihadist group. It investigates Shaikh’s process of disengagement from the Salafi jihadist belief system and his rediscovery of a moderate, inclusive, and benevolent form of Islam. It explores his work as an undercover agent for the Canadian Security Intelligence Service, the Royal Canadian Mounted Police, and the Integrated National Security Enforcement Team responsible for disrupting domestic terrorist groups. The “Toronto 18” terrorist cell, the key role played by undercover agents in preventing terrorist action, and the challenges posed by entrapment are also discussed

    Warm and hot circumstellar gas in V1647 Ori during the 2008-2009 outburst

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    The pre-main sequence star V1647 Ori started a new outburst in August 2008. From October 2008 to February 2009 we monitored V1647 Ori, obtaining quasi-simultaneous VLT-CRIRES near-IR spectroscopy, VLT-VISIR mid-IR spectroscopy and VLT-FORS2 optical spectroscopy. We studied the evolution of H2 and CO emission from hot and warm gas and Hα and forbidden line-emission during the initial outburst phase of V1647 Ori. Hα is observed in emission displaying P-Cygni profiles with blue-shifted absorption up to -700 km/s, suggesting the presence of a high velocity wind (Fig. 1a). [OI] emission at 6300 Å is observed displaying a blue-shifted emission shoulder, indicating the presence of material moving away from the star (Fig. 1b). We detect H2 1-0 S(1) and CO (P4 to P14 and P30-P38) ro-vibrational lines centered at the velocity of the star at all epochs (Fig. 1c & d). This strongly suggests that the H2 and CO emission originates from a disk and not from a warm outflow. The H2 1-0 S(0) and 2-1 S(1) ro-vibrational lines at 2.22 and 2.24 ÎŒm and the pure-rotational H2 0-0 S(1) and 0-0 S(2) lines at 17 and 12 ÎŒm were not detected in our spectra. Changes in the Hα and [OI] profiles and the H2 and CO emission observed do not correlate. We modeled the H2 and CO line profiles assuming emission from a flat disk in keplerian rotation with line intensity decreasing with radius (I ~ I0(R/Rmin)−α). We found that the disk of V1647 Ori is observed nearly face-on and that the line emission is produced within a fraction of an AU of the star (Fig. 1d

    The structure of the protoplanetary disk surrounding three young intermediate mass stars. II. Spatially resolved dust and gas distribution

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    [Abridged] We present the first direct comparison of the distribution of the gas, as traced by the [OI] 6300 AA emission, and the dust, as traced by the 10 micron emission, in the protoplanetary disk around three intermediate-mass stars: HD 101412, HD 135344 B and HD 179218. N-band visibilities were obtained with VLTI/MIDI. Simple geometrical models are used to compare the dust emission to high-resolution optical spectra in the 6300 AA [OI] line of the same targets. The disks around HD 101412 and HD 135344 B appear strongly flared in the gas, but self-shadowed in the dust beyond ~ 2 AU. In both systems, the 10 micron emission is rather compact (< 2 AU) while the [OI] brightness profile shows a double peaked structure. The inner peak is strongest and is consistent with the location of the dust, the outer peak is fainter and is located at 5-10 AU. Spatially extended PAH emission is found in both disks. The disk around HD 179218 is flared in the dust. The 10 micron emission emerges from a double ring-like structure with the first ring peaking at ~ 1 AU and the second at ~ 20 AU. No dust emission is detected between ~ 3 -- 15 AU. The oxygen emission seems also to come from a flared structure, however, the bulk of this emission is produced between ~ 1 -- 10 AU. This could indicate a lack of gas in the outer disk or could be due to chemical effects which reduce the abundance of OH -- the parent molecule of the observed [OI] emission -- further away from the star. The three systems, HD 179218, HD 135344 B and HD 101412, may form an evolutionary sequence: the disk initially flared becomes flat under the combined action of gas-dust decoupling, grain growth and dust settling.Comment: Accepted for publication in A&
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