Instantons on conical half-flat 6-manifolds

We present a general procedure to construct 6-dimensional manifolds with SU(3)-structure from SU(2)-structure 5-manifolds. We thereby obtain half-flat cylinders and sine-cones over 5-manifolds with Sasaki-Einstein SU(2)-structure. They are nearly Kahler in the special case of sine-cones over Sasaki-Einstein 5-manifolds. Both half-flat and nearly Kahler 6-manifolds are prominent in flux compactifications of string theory. Subsequently, we investigate instanton equations for connections on vector bundles over these half-flat manifolds. A suitable ansatz for gauge fields on these 6-manifolds reduces the instanton equation to a set of matrix equations. We finally present some of its solutions and discuss the instanton configurations obtained this way.Comment: 1+32 pages, 1 figure, v2: 6 references added, v2 accepted for publication in JHE

Geometry-Oblivious FMM for Compressing Dense SPD Matrices

We present GOFMM (geometry-oblivious FMM), a novel method that creates a hierarchical low-rank approximation, "compression," of an arbitrary dense symmetric positive definite (SPD) matrix. For many applications, GOFMM enables an approximate matrix-vector multiplication in $N \log N$ or even $N$ time, where $N$ is the matrix size. Compression requires $N \log N$ storage and work. In general, our scheme belongs to the family of hierarchical matrix approximation methods. In particular, it generalizes the fast multipole method (FMM) to a purely algebraic setting by only requiring the ability to sample matrix entries. Neither geometric information (i.e., point coordinates) nor knowledge of how the matrix entries have been generated is required, thus the term "geometry-oblivious." Also, we introduce a shared-memory parallel scheme for hierarchical matrix computations that reduces synchronization barriers. We present results on the Intel Knights Landing and Haswell architectures, and on the NVIDIA Pascal architecture for a variety of matrices.Comment: 13 pages, accepted by SC'1

Instantons on sine-cones over Sasakian manifolds

We investigate instantons on sine-cones over Sasaki-Einstein and 3-Sasakian manifolds. It is shown that these conical Einstein manifolds are K"ahler with torsion (KT) manifolds admitting Hermitian connections with totally antisymmetric torsion. Furthermore, a deformation of the metric on the sine-cone over 3-Sasakian manifolds allows one to introduce a hyper-K"ahler with torsion (HKT) structure. In the large-volume limit these KT and HKT spaces become Calabi-Yau and hyper-K"ahler conifolds, respectively. We construct gauge connections on complex vector bundles over conical KT and HKT manifolds which solve the instanton equations for Yang-Mills fields in higher dimensions.Comment: 1+15 pages, 2 figure

Murine Itk SH3 domain

Interleukin-2 tyrosine kinase (Itk) is a non-receptor tyrosine kinase of the Tec family that is activated upon antigen binding to the T cell receptor (Schwartzberg et al. 2005; Berg 2007). Itk is comprised of four regulatory domains: PH (Pleckstrin homology), TH (Tec homology), SH3, SH2 and the catalytic kinase domain. SH3 domains share a common fold consisting of five anti-parallel β strands that form a β barrel and bind canonical proline rich ligands as well as a variety of noncanonical ligands (Agrawal and Kishan 2002)

Functionalised Clathrochelate Complexes – New Building Blocks for Supramolecular Structures

Tris(dioxime) iron(II) clathrochelate complexes functionalised with 3- and 4-pyridyl groups have been employed as building blocks in the preparation of supramolecular structures by coordination-driven self-assembly. These complexes possess a number of desirable characteristics, being straightforward to synthesise and offering ample opportunity for steric and functional modification. Clathrochelate-based 4,4'-bipyridyl metalloligands from 1.5 nm to 5.4 nm in length were prepared in up to two steps and their potential as building blocks for supramolecular architectures demonstrated through the preparation of a discrete molecular square and a three dimensional (3D) coordination polymer. Furthermore, the structure-directing capability of clathrochelate building blocks was illustrated through the synthesis of octahedral cage compounds, which are capable of encapsulating the large, hydrophobic BPh4– anion in aqueous solvent mixtures