Improving educational process quality in the lessons of natural and mathematical cycle by means of stem-training

Today, the educational process is focused on the development of personal characteristics that meet the requirements of a modern educated person. In this regard, the task of educational institutions is to adopt the educational process to today’s realities. To achieve this goal, STEM education is implemente

Оценки оператора Кордобы - Фернандеса в пространствах Марцинкевича

In the A. Cordoba and P. Fernandez research of the divergence of greedy algorithms in Lebesgue spaces some maximum operator P*(x) played the key role. This article reviews the assessment P*(x) in Marcinkiewicz spaces.В работах А. Кордобы и П. Фернандеса о расходимости жадных алгоритмов в пространствах Лебега ключевую роль играл некоторый максимальный оператор Pn**(x). В настоящей статье рассмотрены оценки P*(x) в пространствах Марцинкевича

Some aspects of the use of chemical weapons in the First world war

The aim of the study - defined as the identification of the consequences of the use of chemical weapons during the First World War.Цель исследования - выявление последствий использования химического оружия во время первой мировой войн

Electromigration-Induced Flow of Islands and Voids on the Cu(001) Surface

Electromigration-induced flow of islands and voids on the Cu(001) surface is studied at the atomic scale. The basic drift mechanisms are identified using a complete set of energy barriers for adatom hopping on the Cu(001) surface, combined with kinetic Monte Carlo simulations. The energy barriers are calculated by the embedded atom method, and parameterized using a simple model. The dependence of the flow on the temperature, the size of the clusters, and the strength of the applied field is obtained. For both islands and voids it is found that edge diffusion is the dominant mass-transport mechanism. The rate limiting steps are identified. For both islands and voids they involve detachment of atoms from corners into the adjacent edge. The energy barriers for these moves are found to be in good agreement with the activation energy for island/void drift obtained from Arrhenius analysis of the simulation results. The relevance of the results to other FCC(001) metal surfaces and their experimental implications are discussed.Comment: 9 pages, 13 ps figure

A clinical case of genetically confirmed myotubular myopathy

The aim of the study - presentation of a clinical case of genetically confirmed myotubular myopathy.Цель исследования – представление клинического случая генетически подтвержденной миотубулярной миопатии

A Large Hadron Electron Collider at CERN

This document provides a brief overview of the recently published report on the design of the Large Hadron Electron Collider (LHeC), which comprises its physics programme, accelerator physics, technology and main detector concepts. The LHeC exploits and develops challenging, though principally existing, accelerator and detector technologies. This summary is complemented by brief illustrations of some of the highlights of the physics programme, which relies on a vastly extended kinematic range, luminosity and unprecedented precision in deep inelastic scattering. Illustrations are provided regarding high precision QCD, new physics (Higgs, SUSY) and electron-ion physics. The LHeC is designed to run synchronously with the LHC in the twenties and to achieve an integrated luminosity of O(100) fb$^{-1}$. It will become the cleanest high resolution microscope of mankind and will substantially extend as well as complement the investigation of the physics of the TeV energy scale, which has been enabled by the LHC

Роль радионуклидной диагностики в комплексном обследовании ВИЧ-инфицированных пациентов с ишемической болезнью сердца

Cardiovascular disease is one of the most frequent cause of death globally. The greatest part is occupied by ischemic heart disease. HIV patients are composed to a higher risk of coronary heart disease.The purpose of this work is to evaluate the possibility of using molecular imaging methods in a comprehensive examination of patients with HIV infection and ischemic heart disease.Materials and methods. The survey group includes 32 patients with HIV infection. The comparison group consists of 25 age-matched patients with coronary heart disease and without HIV Infection. All patients were underwent myocardial perfusion scintigraphy using single photon emission computed tomography. Positron emission tomography with FDG were performed if necessary to assess the viability of the myocardium. The patients of the main group undergo diagnostic coronary angiography and standard set of laboratory and institutional diagnostic methods.Results. The results of which confirm the high efficiency of radionuclide diagnostic methods for detecting perfusion disorders, contractility and myocardial viability in patients with HIV infection even at an early stage. They can be recommended for using in a comprehensive examination of patients with HIV infection.Наиболее частой причиной смертности во всем мире являются сердечно-сосудистые заболевания, среди которых ведущее место занимает ишемическая болезнь сердца (ИБС). В группу с наиболее высоким риском развития ИБС входят пациенты с ВИЧ-инфекцией.Цель исследования: оценка возможности применения методов молекулярной визуализации в комплексном обследовании пациентов с ВИЧ-инфекцией и ИБС.Материал и методы. В группу обследования включено 32 пациента с ВИЧ-инфекцией, группу сравнения составили 25 сопоставимых по возрасту пациентов без ВИЧ-инфекции с ИБС. Всем пациентам проведена перфузионная сцинтиграфия миокарда (с помощью ОФЭКТ), ПЭТ/КТ сердца с ФДГ проводилась при необходимости оценки жизнеспособности миокарда в комплексе с диагностической коронароангиографией и стандартным набором лабораторно-инструментальных методов диагностики.Результаты. Полученные результаты подтверждают высокую эффективностью методов радионуклидной диагностики для выявления нарушений перфузии, сократимости и жизнеспособности миокарда у пациентов с ВИЧ-инфекцией даже на ранней стадии и могут быть рекомендованы к использованию в комплексном обследовании пациентов с ВИЧ-инфекцией

A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning

© 2015 Published by Elsevier B.V. Butyrylcholinesterase is a stoichiometric bioscavenger against poisoning by organophosphorus pesticides and nerve agents. The low level of expression and extremely rapid clearance of monomeric recombinant human butyrylcholinesterase (rhBChE) from bloodstream (t1/2;≈2 min) limits its pharmaceutical application. Recently (Ilyushin at al., PNAS, 2013) we described a long-acting polysialylated recombinant butyrylcholinesterase (rhBChE-CAO), stable in the bloodstream, that protects mice against 4.2 LD50 of VR. Here we report a set of modifications of the initial rhBChE expression vector to improve stability of the enzyme in the bloodstream and increase its production in CHO cells by introducing in the expression cassette: (i) the sequence of the natural human PRAD-peptide in frame with rhBChE gene via "self-processing" viral F2A peptide under control of an hEF/HTLV promoter, and (ii) previously predicted in silico MAR 1-68 and MAR X-29 sequences. This provides fully tetrameric rhBChE (4rhBChE) at 70 mg/l, that displays improved pharmacokinetics (t1/2; = 32 ± 1.2 h, MRT = 43 ± 2 h). 3D Fluorescent visualization and distribution of 125I-labeled enzyme reveals similar low level 4rhBChE and rhBChE-CAO accumulation in muscle, fat, and brain. Administered 4rhBChE was mainly catabolized in the liver and breakdown products were excreted in kidney. Injection of 1.2 LD50 and 1.1 LD50 of paraoxon to BALB/c and knockout BChE-/- mice pre-treated with 4rhBChE (50 mg/kg) resulted in 100% and 78% survival, respectively, without perturbation of long-term behavior. In contrast, 100% mortality of non-pre-treated mice was observed. The high expression level of 4rhBChE in CHO cells permits consideration of this new expression system for manufacturing BChE as a biopharmaceutical

The start of X-ray generator NESTOR comissioning

The first results of the NESTOR facility commissioning are presented. 60 MeV electron linac injector has been tested and the first electron beam with project parameters was registered at the screen monitors. Electron beam was passed through the transportation channel and injection system. The beamh of electrons was observed and controlled in the screen monitors in the expected range.Перші результати вводу в експлуатацію генератора НЕСТОР представлені. Інжектор-лінійний прискорювач на 60 МеВ електронів був випробуван, та перший пучок із проектними параметрами було зареєстровано на екранах моніторів. Електронний пучок проведено крізь канал транспортування та системи вводу в вакуумну камеру накопичувача. Пучок електронів спостерігається і контролюється на екранах моніторів в очікуваному діапазоні.Представлены первые результаты ввода в эксплуатацию генератора НЕСТОР. Инжектор-линейный ускоритель на 60 МэВ электронов был испытан, и первый пучок с проектными параметрами был зарегистрирован на экранах мониторов. Электронный пучок проведен через канал транспортировки и системы ввода в вакуумную камеру накопителя. Пучок электронов наблюдается и контролируется на экране мониторов в ожидаемом диапазоне