7,688 research outputs found
Crystallization and preliminary X-ray diffraction analysis of a biologically active fragment of CD55
Supervision and Scholarly Writing: Writing to Learn - Learning to Write
This paper describes an action research project on postgraduate students’ scholarly writing in which I employed reflective approaches to examine and enhance my postgraduate supervisory practice. My reflections on three distinct cycles of supervision illustrate a shift in thinking about scholarly writing and an evolving understanding of how to support postgraduate students’ writing. These understandings provide the foundation for a future-oriented fourth cycle of supervisory practice, which is characterised by three principles, namely the empowerment of students as writers, the technological context of contemporary writing, and ethical issues in writing
Fluctuations of a Greenlandic tidewater glacier driven by changes in atmospheric forcing : observations and modelling of Kangiata Nunaata Sermia, 1859–present
Acknowledgements. The authors wish to thank Stephen Price, Mauri Pelto, and the anonymous reviewer for their reviews and comments that helped to improve the manuscript. RACMO2.1 data were provided by Jan van Angelen and Michiel van den Broeke, IMAU, Utrecht University. MAR v3.2 data used for runoff calculations were provided by Xavier Fettweis, Department of Geography, University of Liège. The photogrammetric DEM used in Figs. 1 and 3 was provided by Kurt H. Kjær, Centre for GeoGenetics, University of Copenhagen. This research was financially supported by J. M. Lea’s PhD funding, NERC grant number NE/I528742/1. Support for F. M. Nick was provided through the Conoco-Phillips/Lundin Northern Area Program CRIOS project (Calving Rates and Impact on Sea Level).Peer reviewedPublisher PD
Reevaluation of patterns of mussel (Mytilus edulis) selection by European Oystercatchers (Haematopus ostralegus)
© National Research Council of Canada 2002. Published version reproduced with the permission of the publisher.European Oystercatchers (Haematopus ostralegus) were highly selective towards mussels between 35 and 50 mm in length, and fewer than 5% of mussels taken were below 35 mm or above 50 mm. The oystercatchers selected ventrally thin-shelled mussels, especially if the length was more than 35 mm, regardless of whether they opened the right or left valve of the mussel. The oystercatchers also took mussels that had few barnacles on the ventral surface. Although brown-shelled mussels were rare in the population, oystercatchers showed a strong preference for them. Generally, oystercatchers consumed ventrally flat mussels, especially in the smaller length classes, particularly the most preferred size class, 30–45 mm. Ventral shell thickness and colour had independent effects on mussel selection. The other two variables, number of barnacles and shape of the ventral surface (flat or curved), apparently had no influence on selection on their own, only by way of their association with colour or thickness
Reclaiming literacies: competing textual practices in a digital higher education
This essay examines the implications of the ubiquitous use of the term ‘digital literacies’ in higher education and its increasing alignment with institutional and organisational imperatives. It suggests that the term has been stripped of its provenance and association with disciplinary knowledge production and textual practice. Instead it is called into service rhetorically in order to promote competency based agendas both in and outside the academy. The piece also points to a tendency to position teachers in deficit with regard to their technological capabilities and pay scant attention to their own disciplinary and scholarly practices in a digital world. It concludes that there is a case for building on established theoretical and conceptual frameworks from literacy studies if we wish to integrate advantages of the digital landscape with thoughtful teaching practice
CaMKII-dependent responses to ischemia and reperfusion challenges in the heart
Ischemic heart disease is a leading cause of death, and there is considerable imperative to identify effective therapeutic interventions. Cardiomyocyte Ca2+ overload is a major cause of ischemia and reperfusion injury, initiating a cascade of events culminating in cardiomyocyte death, myocardial dysfunction, and occurrence of lethal arrhythmias. Responsive to fluctuations in intracellular Ca2+, Ca2+/calmodulin-dependent protein kinase II (CaMKII) has emerged as an enticing therapeutic target in the management of ischemic heart injury. CaMKII is activated early in ischemia and to a greater extent in the first few minutes of reperfusion, at a time when reperfusion arrhythmias are particularly prominent. CaMKII phosphorylates and upregulates many of the key proteins involved in intracellular Na+ and Ca2+ loading in ischemia and reperfusion. Experimentally, selective inhibition of CaMKII activity reduces cardiomyocyte death and arrhythmic incidence post-ischemia. New evidence is emerging that CaMKII actions in ischemia and reperfusion involve specific splice variant targeted actions, selective and localized post-translational modifications, and organelle-directed substrate interactions. A more complete mechanistic understanding of CaMKII mode of action in ischemia and reperfusion is required to optimize intervention opportunities. This review summarizes the current experimentally derived understanding of CaMKII participation in mediating the pathophysiology of the heart in ischemia and in reperfusion, and highlights priority future research directions.Centro de Investigaciones Cardiovasculare
Transversality of Electromagnetic Waves in the Calculus-Based Introductory Physics Course
Introductory calculus-based physics textbooks state that electromagnetic
waves are transverse and list many of their properties, but most such textbooks
do not bring forth arguments why this is so. Both physical and theoretical
arguments are at a level appropriate for students of courses based on such
books, and could be readily used by instructors of such courses. Here, we
discuss two physical arguments (based on polarization experiments and on lack
of monopole electromagnetic radiation), and the full argument for the
transversality of (plane) electromagnetic waves based on the integral Maxwell
equations. We also show, at a level appropriate for the introductory course,
why the electric and magnetic fields in a wave are in phase and the relation of
their magnitudes.Comment: 10 pages, 6 figure
Magneto-shear modes and a.c. dissipation in a two-dimensional Wigner crystal
The a.c. response of an unpinned and finite 2D Wigner crystal to electric
fields at an angular frequency has been calculated in the dissipative
limit, , where is the scattering rate. For
electrons screened by parallel electrodes, in zero magnetic field the
long-wavelength excitations are a diffusive longitudinal transmission line mode
and a diffusive shear mode. A magnetic field couples these modes together to
form two new magneto-shear modes. The dimensionless coupling parameter where and are the
speeds of transverse and longitudinal sound in the collisionless limit and
and are the tensor components of the
magnetoconductivity. For , both the coupled modes contribute
to the response of 2D electrons in a Corbino disk measurement of
magnetoconductivity. For , the electron crystal rotates rigidly in
a magnetic field. In general, both the amplitude and phase of the measured a.c.
currents are changed by the shear modulus. In principle, both the
magnetoconductivity and the shear modulus can be measured simultaneously.Comment: REVTeX, 7 pp., 4 eps figure
- …