1,759 research outputs found

    Calcium Levels Affect the Ability to Immunolocalize Calmodulin to Cortical Microtubules

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    Benchmarking quantum control methods on a 12-qubit system

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    In this letter, we present an experimental benchmark of operational control methods in quantum information processors extended up to 12 qubits. We implement universal control of this large Hilbert space using two complementary approaches and discuss their accuracy and scalability. Despite decoherence, we were able to reach a 12-coherence state (or 12-qubits pseudo-pure cat state), and decode it into an 11 qubit plus one qutrit labeled observable pseudo-pure state using liquid state nuclear magnetic resonance quantum information processors.Comment: 11 pages, 4 figures, to be published in PR

    Two types of nematicity in the phase diagram of the cuprate superconductor YBa2_2Cu3_3Oy_y

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    Nematicity has emerged as a key feature of cuprate superconductors, but its link to other fundamental properties such as superconductivity, charge order and the pseudogap remains unclear. Here we use measurements of transport anisotropy in YBa2_2Cu3_3Oy_y to distinguish two types of nematicity. The first is associated with short-range charge-density-wave modulations in a doping region near p=0.12p = 0.12. It is detected in the Nernst coefficient, but not in the resistivity. The second type prevails at lower doping, where there are spin modulations but no charge modulations. In this case, the onset of in-plane anisotropy - detected in both the Nernst coefficient and the resistivity - follows a line in the temperature-doping phase diagram that tracks the pseudogap energy. We discuss two possible scenarios for the latter nematicity.Comment: 8 pages and 7 figures. Main text and supplementary material now combined into single articl

    Anisotropy of the Seebeck Coefficient in the Cuprate Superconductor YBa2_{2}Cu3_{3}Oy_{y}: Fermi-Surface Reconstruction by Bidirectional Charge Order

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    The Seebeck coefficient SS of the cuprate YBa2_{2}Cu3_{3}Oy_{y} was measured in magnetic fields large enough to suppress superconductivity, at hole dopings p=0.11p = 0.11 and p=0.12p = 0.12, for heat currents along the aa and bb directions of the orthorhombic crystal structure. For both directions, S/TS/T decreases and becomes negative at low temperature, a signature that the Fermi surface undergoes a reconstruction due to broken translational symmetry. Above a clear threshold field, a strong new feature appears in SbS_{\rm b}, for conduction along the bb axis only. We attribute this feature to the onset of 3D-coherent unidirectional charge-density-wave modulations seen by x-ray diffraction, also along the bb axis only. Because these modulations have a sharp onset temperature well below the temperature where S/TS/T starts to drop towards negative values, we infer that they are not the cause of Fermi-surface reconstruction. Instead, the reconstruction must be caused by the quasi-2D bidirectional modulations that develop at significantly higher temperature.Comment: 7 pages, 5 figure

    Hsp70 in mitochondrial biogenesis

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    The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix

    Broken rotational symmetry in the pseudogap phase of a high-Tc superconductor

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    The nature of the pseudogap phase is a central problem in the quest to understand high-Tc cuprate superconductors. A fundamental question is what symmetries are broken when that phase sets in below a temperature T*. There is evidence from both polarized neutron diffraction and polar Kerr effect measurements that time- reversal symmetry is broken, but at temperatures that differ significantly. Broken rotational symmetry was detected by both resistivity and inelastic neutron scattering at low doping and by scanning tunnelling spectroscopy at low temperature, but with no clear connection to T*. Here we report the observation of a large in-plane anisotropy of the Nernst effect in YBa2Cu3Oy that sets in precisely at T*, throughout the doping phase diagram. We show that the CuO chains of the orthorhombic lattice are not responsible for this anisotropy, which is therefore an intrinsic property of the CuO2 planes. We conclude that the pseudogap phase is an electronic state which strongly breaks four-fold rotational symmetry. This narrows the range of possible states considerably, pointing to stripe or nematic orders.Comment: Published version. Journal reference and DOI adde

    A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

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    Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis

    Lifshitz critical point in the cuprate superconductor YBa2Cu3Oy from high-field Hall effect measurements

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    The Hall coefficient R_H of the cuprate superconductor YBa2Cu3Oy was measured in magnetic fields up to 60 T for a hole concentration p from 0.078 to 0.152, in the underdoped regime. In fields large enough to suppress superconductivity, R_H(T) is seen to go from positive at high temperature to negative at low temperature, for p > 0.08. This change of sign is attributed to the emergence of an electron pocket in the Fermi surface at low temperature. At p < 0.08, the normal-state R_H(T) remains positive at all temperatures, increasing monotonically as T \to 0. We attribute the change of behaviour across p = 0.08 to a Lifshitz transition, namely a change in Fermi-surface topology occurring at a critical concentration p_L = 0.08, where the electron pocket vanishes. The loss of the high-mobility electron pocket across p_L coincides with a ten-fold drop in the conductivity at low temperature, revealed in measurements of the electrical resistivity ρ\rho at high fields, showing that the so-called metal-insulator crossover of cuprates is in fact driven by a Lifshitz transition. It also coincides with a jump in the in-plane anisotropy of ρ\rho, showing that without its electron pocket the Fermi surface must have strong two-fold in-plane anisotropy. These findings are consistent with a Fermi-surface reconstruction caused by a unidirectional spin-density wave or stripe order.Comment: 16 pages, 13 figures, see associated Viewpoint: M. Vojta, Physics 4, 12 (2011
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