292 research outputs found
Ordering of small particles in one-dimensional coherent structures by time-periodic flows
Small particles transported by a fluid medium do not necessarily have to
follow the flow. We show that for a wide class of time-periodic incompressible
flows inertial particles have a tendency to spontaneously align in
one-dimensional dynamic coherent structures. This effect may take place for
particles so small that often they would be expected to behave as passive
tracers and be used in PIV measurement technique. We link the particle tendency
to form one-dimensional structures to the nonlinear phenomenon of phase
locking. We propose that this general mechanism is, in particular, responsible
for the enigmatic formation of the `particle accumulation structures'
discovered experimentally in thermocapillary flows more than a decade ago and
unexplained until now
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Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females.
IntroductionDuring adolescence, exposure to nicotine or cannabis independently induces effects on neuromaturation and later cognitive function. However, the potential effect of both drugs under co-use conditions has become of increasing concern given the prevalence of e-cigarettes, legalization of cannabis, and availability of synthetic "spice" cannabinoid agonists.Aims and methodsThe current studies investigated the effects of exposure to a cannabinoid receptor agonist (WIN55,212-2) and/or nicotine over a discrete time period in mid-adolescence on later intravenous nicotine self-administration in adult male and female mice. We further examined whether cannabinoid agonist administration in adulthood would alter nicotine reinforcement, with either acute or chronic pairing across 7 days.ResultsWe found that adult males exhibited increased nicotine self-administration at a lower, rewarding nicotine dose following adolescent cannabinoid exposure, either alone or with nicotine coadministration. In contrast, adult females demonstrated an opposing effect in which adolescent cannabinoid and nicotine coexposure resulted in decreased nicotine intake compared with the nicotine only and control groups. Furthermore, after maintaining nicotine self-administration across sessions, pretreatment with a low dose of the cannabinoid agonist decreased nicotine intake in both male and female control mice, and this lowering effect was evidenced after both acute and chronic treatment. However, the cannabinoid agonist was ineffective in altering nicotine intake in mice previously exposed to nicotine, cannabinoid agonist, or both during adolescence.ConclusionsThese data provide evidence that adolescent drug exposure can alter later nicotine reinforcement in a sex-specific manner and can further modulate the effectiveness of interventions in reducing nicotine intake during adulthood.ImplicationsThese studies demonstrate a significant impact of nicotine, cannabinoids, or coexposure on developmental processes during adolescence. Differential effects were observed within each sex, with opposing results found for cannabinoid exposure on nicotine intake in males and females. Intriguingly, we also evidenced resistance to the lowering effects of a cannabinoid agonist on nicotine intake in adulthood based on adolescent drug exposure. Thus, these findings have important implications for our understanding of the impact of nicotine and cannabinoids (eg, Δ9-tetrahydrocannabinol (THC) and synthetic "spice" cannabinoids) during development, with further implications for the effectiveness of therapeutic interventions based on prior drug exposure in youth
The JEREMI-project on thermocapillary convection in liquid bridges. Part A : Overview of particle accumulation structures
The rapid accumulation of particles suspended in a thermocapillary liquid bridge is planned to be investigated during the JEREMI experiment on the International Space Station scheduled for 2016. An overview is given of the current status of experimental and numerical investigations of this phenomenon
Low Energy Electron and Nuclear Recoil Thresholds in the DRIFT-II Negative Ion TPC for Dark Matter Searches
Understanding the ability to measure and discriminate particle events at the
lowest possible energy is an essential requirement in developing new
experiments to search for weakly interacting massive particle (WIMP) dark
matter. In this paper we detail an assessment of the potential sensitivity
below 10 keV in the 1 m^3 DRIFT-II directionally sensitive, low pressure,
negative ion time projection chamber (NITPC), based on event-by-event track
reconstruction and calorimetry in the multiwire proportional chamber (MWPC)
readout. By application of a digital smoothing polynomial it is shown that the
detector is sensitive to sulfur and carbon recoils down to 2.9 and 1.9 keV
respectively, and 1.2 keV for electron induced events. The energy sensitivity
is demonstrated through the 5.9 keV gamma spectrum of 55Fe, where the energy
resolution is sufficient to identify the escape peak. The effect a lower energy
sensitivity on the WIMP exclusion limit is demonstrated. In addition to recoil
direction reconstruction for WIMP searches this sensitivity suggests new
prospects for applications also in KK axion searches
The DRIFT Dark Matter Experiments
The current status of the DRIFT (Directional Recoil Identification From
Tracks) experiment at Boulby Mine is presented, including the latest limits on
the WIMP spin-dependent cross-section from 1.5 kg days of running with a
mixture of CS2 and CF4. Planned upgrades to DRIFT IId are detailed, along with
ongoing work towards DRIFT III, which aims to be the world's first 10 m3-scale
directional Dark Matter detector.Comment: Proceedings of the 3rd International conference on Directional
Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10 June 201
Melting Point and Lattice Parameter Shifts in Supported Metal Nanoclusters
The dependencies of the melting point and the lattice parameter of supported
metal nanoclusters as functions of clusters height are theoretically
investigated in the framework of the uniform approach. The vacancy mechanism
describing the melting point and the lattice parameter shifts in nanoclusters
with decrease of their size is proposed. It is shown that under the high vacuum
conditions (p<10^-7 torr) the essential role in clusters melting point and
lattice parameter shifts is played by the van der Waals forces of
cluster-substrate interation. The proposed model satisfactorily accounts for
the experimental data.Comment: 6 pages, 3 figures, 1 tabl
A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug–Drug Interaction
BACKGROUND: Fusidic acid (FA) has been used for decades for bone infection, including prosthetic joint infection (PJI), often in combination with rifampin (RIF). An FA/RIF pharmacokinetic interaction has not previously been described.
METHODS: In a phase 2 open-label randomized study, we evaluated oral FA/RIF vs standard-of-care (SOC) intravenous antibiotics for treatment of hip or knee PJI. Outcome assessment occurred at reimplantation (week 12) for subjects with 2-stage exchange, and after 3 or 6 months of treatment for subjects with hip or knee debride and retain strategies, respectively.
RESULTS: Fourteen subjects were randomized 1:1 to FA/RIF or SOC. Pharmacokinetic profiles were obtained for 6 subjects randomized to FA/RIF. FA concentrations were lower than anticipated in all subjects during the first week of therapy, and at weeks 4 and 6, blood levels continued to decline. By week 6, FA exposures were 40%-45% lower than expected.
CONCLUSIONS: The sponsor elected to terminate this study due to a clearly illustrated drug-drug interaction between FA and RIF, which lowered FA levels to a degree that could influence subject outcomes. Optimization of FA exposure if used in combination with RIF should be a topic of future research.
CLINICAL TRIALS REGISTRATION: NCT01756924
Radiative capture and electromagnetic dissociation involving loosely bound nuclei: the B example
Electromagnetic processes in loosely bound nuclei are investigated using an
analytical model. In particular, electromagnetic dissociation of B is
studied and the results of our analytical model are compared to numerical
calculations based on a three-body picture of the B bound state. The
calculation of energy spectra is shown to be strongly model dependent. This is
demonstrated by investigating the sensitivity to the rms intercluster distance,
the few-body behavior, and the effects of final state interaction. In contrast,
the fraction of the energy spectrum which can be attributed to E1 transitions
is found to be almost model independent at small relative energies. This
finding is of great importance for astrophysical applications as it provides us
with a new tool to extract the E1 component from measured energy spectra. An
additional, and independent, method is also proposed as it is demonstrated how
two sets of experimental data, obtained with different beam energy and/or
minimum impact parameter, can be used to extract the E1 component.Comment: Submitted to Phys. Rev. C. 10 pages, 7 figure
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