A first-in-human, randomized, controlled, subject- and reviewer-blinded multicenter study of Actamax™ Adhesion Barrier

Purpose: Post-surgical adhesions remain a significant concern following abdominopelvic surgery. This study was to assess safety, manageability and explore preliminary efficacy of applying a degradable hydrogel adhesion barrier to areas of surgical trauma following gynecologic laparoscopic abdominopelvic surgery. Methods: This first-in-human, prospective, randomized, multicenter, subject- and reviewer-blinded clinical study was conducted in 78 premenopausal women (18–46 years) wishing to maintain fertility and undergoing gynecologic laparoscopic abdominopelvic surgery with planned clinically indicated second-look laparoscopy (SLL) at 4–12 weeks. The first two patients of each surgeon received hydrogel, up to 30 mL sprayed over all sites of surgical trauma, and were assessed for safety and application only (n = 12). Subsequent subjects (n = 66) were randomized 1:1 to receive either hydrogel (Treatment, n = 35) or not (Control, n = 31); 63 completed the SLL. Results: No adverse event was assessed as serious, or possibly device related. None was severe or fatal. Adverse events were reported for 17 treated subjects (17/47, 36.2%) and 13 Controls (13/31, 41.9%). For 95.7% of treated subjects, surgeons found the device “easy” or “very easy” to use; in 54.5%, some residual material was evident at SLL. For 63 randomized subjects who completed the SLL, adjusted between-group difference in the change from baseline adhesion score demonstrated a 41.4% reduction for Treatment compared with Controls (p = 0.017), with a 49.5% reduction (p = 0.008) among myomectomy subjects (n = 34). Conclusion: Spray application of a degradable hydrogel adhesion barrier during gynecologic laparoscopic abdominopelvic surgery was performed easily and safely, without evidence of clinically significant adverse outcomes. Data suggest the hydrogel was effective in reducing postoperative adhesion development, particularly following myomectomy

Necessary and sufficient optimality conditions for scheduling unit time jobs on identical parallel machines

In this paper we characterize optimal schedules for scheduling problems with parallel machines and unit processing times by providing necessary and sufficient conditions of optimality. We show that the optimality conditions for parallel machine scheduling are equivalent to detecting negative cycles in a specially defined graph. For a range of the objective functions, we give an insight into the underlying structure of the graph and specify the simplest types of cycles involved in the optimality conditions. Using our results we demonstrate that the optimality check can be performed by faster algorithms in comparison with existing approaches based on sufficient conditions

Single-machine scheduling with stepwise tardiness costs and release times

We study a scheduling problem that belongs to the yard operations component of the railroad planning problems, namely the hump sequencing problem. The scheduling problem is characterized as a single-machine problem with stepwise tardiness cost objectives. This is a new scheduling criterion which is also relevant in the context of traditional machine scheduling problems. We produce complexity results that characterize some cases of the problem as pseudo-polynomially solvable. For the difficult-to-solve cases of the problem, we develop mathematical programming formulations, and propose heuristic algorithms. We test the formulations and heuristic algorithms on randomly generated single-machine scheduling problems and real-life datasets for the hump sequencing problem. Our experiments show promising results for both sets of problems

Ownership and control in a competitive industry

We study a differentiated product market in which an investor initially owns a controlling stake in one of two competing firms and may acquire a non-controlling or a controlling stake in a competitor, either directly using her own assets, or indirectly via the controlled firm. While industry profits are maximized within a symmetric two product monopoly, the investor attains this only in exceptional cases. Instead, she sometimes acquires a noncontrolling stake. Or she invests asymmetrically rather than pursuing a full takeover if she acquires a controlling one. Generally, she invests indirectly if she only wants to affect the product market outcome, and directly if acquiring shares is profitable per se. --differentiated products,separation of ownership and control,private benefits of control

Proposed astrophysical test of Lorentz invariance

Working in the context of a Lorentz-violating extension of the standard model we show that estimates of Lorentz symmetry violation extracted from ultra-high energy cosmic rays beyond the Greisen-Kuzmin-Zatsepin (GZK) cutoff allow for setting bounds on parameters of that extension. Furthermore, we argue that a correlated measurement of the difference in the arrival time of gamma-ray photons and neutrinos emitted from active galactic nuclei or gamma-ray bursts may provide a signature of possible violation of Lorentz symmetry. We have found that this time delay is energy independent, however it has a dependence on the chirality of the particles involved. We also briefly discuss the known settings where the mechanism for spontaneous violation of Lorentz symmetry in the context of string/M-theory may take place.Comment: Typos corrected. Version to appear in Phys. Rev.

Rescheduling in passenger railways: the rolling stock rebalancing problem

This paper addresses the Rolling Stock Rebalancing Problem (RSRP) which arises within a passenger railway operator when the rolling stock has to be rescheduled due to changing circumstances. RSRP is relevant both in the short-term planning stage and in the real-time operations. RSRP has as input a timetable and a rolling stock circulation where the allocation of the rolling stock among the stations at the start or at the end of a certain planning period does not match with the allocation before or after that planning period. The problem is then to modify the input rolling stock circulation in such a way that the number of remaining off-balances is minimal. If all off-balances have been solved, then the obtained rolling stock circulation can be implemented in practice. For practical usage of solution approaches for RSRP, it is important to solve the problem quickly. Since we prove that RSRP is NP-hard, we focus on heuristic solution approaches: we describe two heuristics and compare them with each other on (variants of) real-life instances of NS, the main Dutch passenger railway operator. Finally, to get further insight in the quality of the proposed heuristics, we also compare their outcomes with optimal solutions obtained by solving an existing rolling stock circulation model

High-Energy Tests of Lorentz Invariance

We develop a perturbative framework with which to discuss departures from exact Lorentz invariance and explore their potentially observable ramifications. Tiny non-invariant terms introduced into the standard model Lagrangian are assumed to be renormalizable (dimension $\le 4$), invariant under $SU(3)\otimes SU(2)\otimes U(1)$ gauge transformations, and rotationally and translationally invariant in a preferred frame. There are a total of 46 independent TCP-even perturbations of this kind, all of which preserve anomaly cancellation. They define the energy-momentum eigenstates and their maximal attainable velocities in the high-energy limit. The effects of these perturbations increase rapidly with energy in the preferred frame, more rapidly than those of TCP-odd perturbations. Our analysis of Lorentz-violating kinematics reveals several striking new phenomena that are relevant both to cosmic-ray physics ({\it e.g.,} by undoing the GZK cutoff) and neutrino physics ({\it e.g.,} by generating novel types of neutrino oscillations). These may lead to new and sensitive high-energy tests of special relativity.Comment: 33 pages, uses harvmac. This 2nd revision corrects two typos, an error in the Appendix, and includes further acknowledgement

A Hybrid Model for Dynamic Simulation of Custom Software Projects in a Multiproject Environment

This paper describes SimHiProS, a hybrid simulation model of software production. The goal is to gain insight on the dynamics induced by resource sharing in multiproject management. In order to achieve it the hierarchy of decisions in a multiproject organization is modeled and some resource allocation methods based on algorithms from the OR/AI domain are used. Other critical issues such as the hybrid nature of software production and the effects of measurement and control are also incorporated in the model. Some first results are presented.Ministerio de Ciencia e Innovación TIN2004-06689-C03-03Ministerio de Ciencia e Innovación TIN2007-67843-C06-0

Generating Multi-objective Optimized Business Process Enactment Plans

Declarative business process (BP) models are increasingly used allowing their users to specify what has to be done instead of how. Due to their flexible nature, there are several enactment plans related to a specific declarative model, each one presenting specific values for different objective functions, e.g., completion time or profit. In this work, a method for generating optimized BP enactment plans from declarative specifications is proposed to optimize the performance of a process considering multiple objectives. The plans can be used for different purposes, e.g., providing recommendations. The proposed approach is validated through an empirical evaluation based on a real-world case study.Ministerio de Ciencia e Innovación TIN2009-1371