Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit

The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level of neurotransmission. Here, we show that cholinergic neurons grown in an autaptic circuit in the absence of glia sense the loss of half of their synaptic contacts triggered by exposure to peptide p4.2, a C-terminal fragment of SPARC. Synaptic elimination is driven by a reorganization of the periodic F-actin cytoskeleton present along neurites, and occurs without altering the density of postsynaptic receptors. Neurons recover baseline neurotransmission through a homeostatic presynaptic response that consists of the coordinated activation of rapid synapse formation and an overall potentiation of presynaptic calcium influx. These results demonstrate that neurons establishing autaptic connections continuously sense and adjust their synaptic output by tweaking the number of functional contacts and neurotransmitter release probability

Iron Displacements and Magnetoelastic Coupling in the Spin-Ladder Compound BaFe2Se3

We report long-range ordered antiferromagnetism concomitant with local iron displacements in the spin-ladder compound BaFe$_2$Se$_3$. Short-range magnetic correlations, present at room temperature, develop into long-range antiferromagnetic order below T$_N$ = 256 K, with no superconductivity down to 1.8 K. Built of ferromagnetic Fe$_4$ plaquettes, the magnetic ground state correlates with local displacements of the Fe atoms. These iron displacements imply significant magnetoelastic coupling in FeX$_4$-based materials, an ingredient hypothesized to be important in the emergence of superconductivity. This result also suggests that knowledge of these local displacements is essential for properly understanding the electronic structure of these systems. As with the copper oxide superconductors two decades ago, our results highlight the importance of reduced dimensionality spin ladder compounds in the study of the coupling of spin, charge, and atom positions in superconducting materials

Optimal control of dissipation and work fluctuations for rapidly driven systems

To achieve efficient and reliable control of microscopic systems one should look for driving protocols that mitigate both the average dissipation and stochastic fluctuations in work. This is especially important in fast driving regimes in which the system is driven far out of equilibrium, potentially creating large amounts of unwanted entropy production. Here we characterise these optimal protocols in rapidly driven classical and quantum systems and prove that they consist of two discontinuous jumps in the full set of control variables. These jumps can be tuned to interpolate between processes with either minimal dissipation or minimal fluctuations, and in some situations allow for simultaneous minimisation. We illustrate our general results with rapidly driven closed quantum systems, classical bit erasure and a dissipative Ising chain driven close to a quantum phase transition.Comment: 16 pages, 3 figures, comments welcom

Orbital Selective Magnetism in the Spin-Ladder Iron Selenides Ba1−x_{1-x}Kx_{x}Fe2_2Se3_3

Here we show that the 2.80(8) {\mu}B/Fe block antiferromagnetic order of BaFe2Se3 transforms into stripe antiferromagnetic order in KFe2Se3 with a decrease in moment to 2.1(1) {\mu}B/Fe. This reduction is larger than expected from the change in electron count from Ba$^{2+}$ to K$^{+}$, and occurs with the loss of the displacements of Fe atoms from ideal positions in the ladders, as found by neutron pair distribution function analysis. Intermediate compositions remain insulating, and magnetic susceptibility measurements show a suppression of magnetic order and probable formation of a spin-glass. Together, these results imply an orbital-dependent selection of magnetic versus bonded behavior, driven by relative bandwidths and fillings.Comment: Final versio