Electroplating eliminates gas leakage in brazed areas

Electroplating method seals brazed or welded joints against gas leakage under high pressure. Any conventional electroplating process with many different metal anodes can be used, as well as the build up of layers of different metals to any required thickness

On the thermodynamics and approximation theory of viscoelastic materials

Thermodynamic properties and approximation method for viscoelastic material

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.

The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases INa. The time-course for SUMOylation of single NaV1.2 channels at the cell surface and changes in INa coincide, and both are prevented by mutation of NaV1.2-Lys38 or application of a deSUMOylating enzyme. Within 40 s, hypoxia-induced linkage of SUMO1 to the channels is complete, shifting the voltage-dependence of channel activation so that depolarizing steps evoke larger sodium currents. Given the recognized role of INa in hypoxic brain damage, the SUMO pathway and NaV1.2 are identified as potential targets for neuroprotective interventions

K2P channels and their protein partners.

A decade since their discovery, the K2P channels are recognized as pathways dedicated to regulated background leakage of potassium ions that serve to control neuronal excitability. The recent identification of protein partners that directly interact with K2P channels (SUMO, 14-3-3 and Vpu1) has exposed new regulatory pathways. Reversible linkage to SUMO silences K2P1 plasma membrane channels; phosphorylation of K2P3 enables 14-3-3 binding to affect forward trafficking, whereas it decreases open probability of K2P2; and, Vpu1, an HIV encoded partner, mediates assembly-dependent degradation of K2P3. An operational strategy has emerged: tonic inhibition of K2P channels allows baseline neuronal activity until enhanced potassium leak is required to suppress excitability

Renewable Energy Resources Impact on Clean Electrical Power by developing the North-West England Hydro Resource Model.

This paper describes the development of a sequential decision support system to promote hydroelectric power in North-West England. The system, composed of integrated models, addresses barriers to the installation of hydroelectric power schemes. Information is linked through an economic assessment which identifies different turbine options, assesses their suitability for location and demand; and combines the different types of information in a way that supports decision making. The system is structured into five components: the hydrological resource is modelled using Low Flows 2000, the turbine options are identified from hydrological, environmental and demand requirements; and the consequences of different solutions will be fed into other components so that the environmental impacts and public acceptability can be assessed and valued. A preliminary case study is presented on an old gunpowder works to illustrate how the resource model may be employed. Historical architectural structures, power uptake and educational instruction of hydro power technology are considered

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits.

KCNE1 (E1) β-subunits assemble with KCNQ1 (Q1) voltage-gated K(+) channel α-subunits to form IKslow (IKs) channels in the heart and ear. The number of E1 subunits in IKs channels has been an issue of ongoing debate. Here, we use single-molecule spectroscopy to demonstrate that surface IKs channels with human subunits contain two E1 and four Q1 subunits. This stoichiometry does not vary. Thus, IKs channels in cells with elevated levels of E1 carry no more than two E1 subunits. Cells with low levels of E1 produce IKs channels with two E1 subunits and Q1 channels with no E1 subunits--channels with one E1 do not appear to form or are restricted from surface expression. The plethora of models of cardiac function, transgenic animals, and drug screens based on variable E1 stoichiometry do not reflect physiology

SYM, Chern-Simons, Wess-Zumino Couplings and their higher derivative corrections in IIA Superstring theory

We find the entire form of the amplitude of two fermion strings (with different chirality), a massless scalar field and one closed string Ramond-Ramond (RR) in IIA superstring theory which is different from its IIB one. We make use of a very particular gauge fixing and explore several new couplings in IIA. All infinite $u$- channel scalar poles and $t,s$- channel fermion poles are also constructed. We find new form of higher derivative corrections to two fermion two scalar couplings and show that the first simple $(s+t+u)-$ channel scalar pole for $p+2=n$ case can be obtained by having new higher derivative corrections to SYM couplings at third order of $\alpha'$. We find that the general structure and the coefficients of higher derivative corrections to two fermion two scalar couplings are completely different from the derived $\alpha'$ higher derivative corrections of type IIB.Comment: 29 pages, no figure,Latex file,published version in EPJ