Mexiletine-quinidine combination: Electrophysiologic correlates of a favorable antiarrhythmic interaction in humans

Combination therapy with mexiletine and quinidine has been shown to be more effective than either agent alone. The ability of mexiletine monotherapy, quinidine monotherapy and mexiletine-quinidine combination therapy to suppress inducible sustained ventricular tachycardia was related to drug-induced changes in ventricular refractoriness, conduction times and monophasic action potential duration recorded from both ventricles. Ventricular tachycardia could no longer be induced in 7 (35%) of the 20 patients studied with combination therapy. This was a significantly higher proportion of patients than that of the groups responding to either monotherapy (quinidine, 10%; mexiletine, 5%).Ventricular effective and functional refractory periods were measured when applying single (S2), double (S3) and triple (S4) extrastimuli. Quinidine monotherapy increased functional and effective refractory periods of both single and multiple extrastimuli. However, when comparing measurements made during mexiletine treatment with those at baseline, mexiletine monotherapy increased only the refractory periods of S4. The effective refractory period of S4 during mexiletine monotherapy (200 ± 20 ins) was significantly longer than at baseline (160 ± 21 ms). Similarly, when comparing measurements made during combination therapy with those during quinidine monotherapy, combination therapy significantly increased the refractory periods only of multiple extrastimuli. The effective refractory period of S4 during combination therapy (253 ± 26 ms) was significantly longer than that of quinidine monotherapy (223 ± 27 ms). The only other significant difference between combination therapy and monotherapy with either agent was a greater prolongation of conduction time to the left ventricular dyskinetic zone with combination therapy.Therefore, mexiletine-quinidine combination therapy is associated with additional prolongation of the refractory periods of multiple extrastimuli and with further prolongation of conduction into the dyskinetic zone of the left ventricle. These electrophysiologic effects may be markers of enhanced antiarrhythmic activity

Identification and control of American germander

1 online resource (PDF, 2 pages)This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu

High resolution infrared spectra of bulge globular clusters: Liller~1 and NGC 6553

Using the NIRSPEC spectrograph at Keck II, we have obtained echelle spectra covering the range 1.5-1.8um for 2 of the brightest giants in Liller 1 and NGC 6553, old metal rich globular clusters in the Galactic bulge. We use spectrum synthesis for the abundance analysis, and find [Fe/H]=-0.3 +/- 0.2 and [O/H]=+0.3 +/- 0.2 dex. The composition of the clusters is similar to that of field stars in the bulge and is consistent with a sceanrio in which the clusters formed early, with rapid enrichment. We have dificulty achieveing a good fit to the spectrum of NGC 6553 using either the low or the high values recently reported in the literature, unless unusually large, or no alpha-element enhancements are adopted, respectively.Comment: To appear in the Astronomical Journal, March 200

The Accretion of Lyman Alplha Clouds onto Gas-Rech Protogalaxies; A Scenario for the Formation of Globular Star Clusters

A satisfactory theory for the formation of globular star clusters (GCs) has long been elusive, perhaps because their true progenitors had not yet been guessed. In this paper I propose a causal relationship between the strongly decreasing densities of Lyman alpha (LyA) clouds at high redshift and the formation of GCs - namely that GCs were created by the accretion of LyA clouds onto protogalaxies. I describe a scenario which involves an inherently stable and orderly cycling of compression and cooling in the central cores of clouds during the extended period of dissipation in the outer regins of gas-rich proto galaxies, culminating in a burst of efficient star formation. I demonstrate that the comoving density of GCs is comparable to that of LyA clouds at high redshift, that the energetic requirements for compression to core GC densities can be met, and that the time-scale for cooling is within obvious limits imposed by dynamical stability. This dissipative process requires there to be a large column of dissipated gas about the attractor in order to form GCs. In addition, the energy requirements for compression requires attractor masses greater than that capable of sustaining circular velocities of ~40 km/s. If this scenario is supported by numerical simulations, then by implication, the GCs were formed at modest redshifts of z~1-3. This knowledge could help to break the degeneracy between lookback time and redshift. The model is consistent with a picture of hierarchical galaxy growth over time scales of many billions of years.Comment: 7 pages. Accepted, 10 June 1999 Astrophysical Journa

APASS Landolt-Sloan BVgri photometry of RAVE stars. I. Data, effective temperatures and reddenings

We provide APASS photometry in the Landolt BV and Sloan g'r'i' bands for all the 425,743 stars included in the latest 4th RAVE Data Release. The internal accuracy of the APASS photometry of RAVE stars, expressed as error of the mean of data obtained and separately calibrated over a median of 4 distinct observing epochs and distributed between 2009 and 2013, is 0.013, 0.012, 0.012, 0.014 and 0.021 mag for B, V, g', r' and i' band, respectively. The equally high external accuracy of APASS photometry has been verified on secondary Landolt and Sloan photometric standard stars not involved in the APASS calibration process, and on a large body of literature data on field and cluster stars, confirming the absence of offsets and trends. Compared with the Carlsberg Meridian Catalog (CMC-15), APASS astrometry of RAVE stars is accurate to a median value of 0.098 arcsec. Brightness distribution functions for the RAVE stars have been derived in all bands. APASS photometry of RAVE stars, augmented by 2MASS JHK infrared data, has been chi2 fitted to a densely populated synthetic photometric library designed to widely explore in temperature, surface gravity, metallicity and reddening. Resulting Teff and E(B-V), computed over a range of options, are provided and discussed, and will be kept updated in response to future APASS and RAVE data releases. In the process it is found that the reddening caused by an homogeneous slab of dust, extending for 140 pc on either side of the Galactic plane and responsible for E(B-V,poles)=0.036 +/- 0.002 at the galactic poles, is a suitable approximation of the actual reddening encountered at Galactic latitudes |b|>=25 deg.Comment: Astronomical Journal, in press. Resolution of Figures degrated to match arXiv file size limit

ISOGAL-DENIS detection of red giants with weak mass loss in the Galactic Bulge

The ISOGAL project is a survey of the stellar populations, structure, and recent star formation history of the inner disk and bulge of the Galaxy. ISOGAL combines 15 and 7micron ISOCAM observations with DENIS IJKs data to determine the nature of a source and the interstellar extinction. In this paper we report an ISOGAL study of a small field in the inner Galactic Bulge (l=0deg, b=1.0deg, area=0.035 sq. deg) as a prototype of the larger area ISOGAL survey of the inner Galaxy. The five wavelengths of ISOGAL+DENIS, together with the relatively low and constant extinction in front of this specific field, allow reliable determination of the nature of the sources. The primary scientific result of this paper is evidence that the most numerous class of ISOGAL 15micron sources are Red Giants in the Galactic bulge and central disk, with luminosities just above or close to the RGB tip and weak mass-loss rates. They form loose sequences in the magnitude-colour diagrams [15]/Ks-[15] and [15]/[7]-[15]. Their large excesses at 15micron with respect to 2micron and 7micron is due to circumstellar dust produced by mass-loss at low rates. These ISOGAL results are the first systematic evidence and study of dust emission at this early stage (''Intermediate'' AGB), before the onset of the large mass-loss phase. It is thus well established that efficient dust formation is already associated with such low mass-loss rates during this early phase.Comment: 15 pages, 9 figures, accepted for publication in Astronomy and Astrophysics Journa

An inverse method to interpret colour-magnitude diagrams

An inverse method is developed to determine the star formation history, the age-metallicity relation, and the IMF slope from a colour-magnitude diagram. The method is applied to the Hipparcos HR diagram. We found that the thin disk of our Galaxy shows a peak of stellar formation 1.6 Gyr ago. The stars close to the Sun have a solar metallicity and a mean IMF index equal to 3.2. However, the model and the evolutionary tracks do not correctly reproduce the horizontal giant branch.Comment: 14 pages, 11 figures. To be published in Astronomy & Astrophysic