Phase detection at the quantum limit with multi-photon Mach-Zehnder interferometry

We study a Mach-Zehnder interferometer fed by a coherent state in one input port and vacuum in the other. We explore a Bayesian phase estimation strategy to demonstrate that it is possible to achieve the standard quantum limit independently from the true value of the phase shift and specific assumptions on the noise of the interferometer. We have been able to implement the protocol using parallel operation of two photon-number-resolving detectors and multiphoton coincidence logic electronics at the output ports of a weakly-illuminated Mach-Zehnder interferometer. This protocol is unbiased and saturates the Cramer-Rao phase uncertainty bound and, therefore, is an optimal phase estimation strategy.Comment: 4 pages, 5 figures replaced fig. 1 to correct graphics bu

Scale-Invariance and the Strong Coupling Problem

The effective theory of adiabatic fluctuations around arbitrary Friedmann-Robertson-Walker backgrounds - both expanding and contracting - allows for more than one way to obtain scale-invariant two-point correlations. However, as we show in this paper, it is challenging to produce scale-invariant fluctuations that are weakly coupled over the range of wavelengths accessible to cosmological observations. In particular, requiring the background to be a dynamical attractor, the curvature fluctuations are scale-invariant and weakly coupled for at least 10 e-folds only if the background is close to de Sitter space. In this case, the time-translation invariance of the background guarantees time-independent n-point functions. For non-attractor solutions, any predictions depend on assumptions about the evolution of the background even when the perturbations are outside of the horizon. For the simplest such scenario we identify the regions of the parameter space that avoid both classical and quantum mechanical strong coupling problems. Finally, we present extensions of our results to backgrounds in which higher-derivative terms play a significant role.Comment: 17 pages + appendices, 3 figures; v2: typos fixe

Density Perturbations in the Ekpyrotic Scenario

We study the generation of density perturbations in the ekpyrotic scenario for the early universe, including gravitational backreaction. We expose interesting subtleties that apply to both inflationary and ekpyrotic models. Our analysis includes a detailed proposal of how the perturbations generated in a contracting phase may be matched across a `bounce' to those in an expanding hot big bang phase. For the physical conditions relevant to the ekpyrotic scenario, we re-obtain our earlier result of a nearly scale-invariant spectrum of energy density perturbations. We find that the perturbation amplitude is typically small, as desired to match observation.Comment: 36 pages, compressed and RevTex file, one postscript figure file. Minor typographical and numerical errors corrected, discussion added. This version to appear in Physical Review

The four fixed points of scale invariant single field cosmological models

We introduce a new set of flow parameters to describe the time dependence of the equation of state and the speed of sound in single field cosmological models. A scale invariant power spectrum is produced if these flow parameters satisfy specific dynamical equations. We analyze the flow of these parameters and find four types of fixed points that encompass all known single field models. Moreover, near each fixed point we uncover new models where the scale invariance of the power spectrum relies on having simultaneously time varying speed of sound and equation of state. We describe several distinctive new models and discuss constraints from strong coupling and superluminality.Comment: 24 pages, 6 figure

Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome

Despite the lack of international agreement regarding the definition and classification of fiber, there is established evidence on the role of dietary fibers in obesity and metabolic syndrome. Beta glucan (β-glucan) is a soluble fiber readily available from oat and barley grains that has been gaining interest due to its multiple functional and bioactive properties. Its beneficial role in insulin resistance, dyslipidemia, hypertension, and obesity is being continuously documented. The fermentability of β-glucans and their ability to form highly viscous solutions in the human gut may constitute the basis of their health benefits. Consequently, the applicability of β-glucan as a food ingredient is being widely considered with the dual purposes of increasing the fiber content of food products and enhancing their health properties. Therefore, this paper explores the role of β-glucans in the prevention and treatment of characteristics of the metabolic syndrome, their underlying mechanisms of action, and their potential in food applications

The Coronavirus Pandemic: A Pitfall or a Fast Track for Validating Cell Therapy Products?

The global COVID-19 pandemic has prompted urgent need for potential therapies for severe respiratory consequences resulting from coronavirus infection. New therapeutic agents that will attenuate ongoing inflammation and at the same time promote regeneration of injured lung epithelial cells are urgently needed. Cell-based therapies, primarily involving mesenchymal stromal cells (MSCs) and their derivatives, are currently investigated worldwide for SARS-CoV-2-induced lung diseases. A significant number of academic centers and companies globally have already initiated such trials. However, at a time of unprecedented need, it is also foreseen that families and caregivers will seek all available options, including access to cell-based and other investigational products, even before proven safety and efficacy as well as regulatory approval. This should not be an excuse for opportunists to sell or advertise unproven therapies of any kind. "Compassionate use" should be conducted in the context of a clinical investigation framed by strict ethical and regulatory permissions, with the goal of obtaining mechanistic information wherever possible

3D visualisation tool for improving the resilience to urban and coastal flooding in Torbay, UK

This is the final version of the article. Available from Elsevier via the DOI in this record.Torbay, located in South West England, UK, is one of the Case Studies on the EU-funded project EU-CIRCLE, which is aimed at enhancing resilience of Critical Infrastructures (CI) to natural hazards. The region includes three urban centres (Torquay, Paignton and Brixham) and hosts more than 3 million tourists every year that contribute over £450 million to local economy. However, flooding, including coastal, fluvial and pluvial, has been a major threat to the area with more than 15 major incidents occurring since 1999. Rising sea levels, combined with increasing rainfall intensity, linked to climate change, are expected to exacerbate the problem. Better adaptation strategies are needed to safeguard CIs and services while improving resilience to climate hazards. EU-CIRCLE partners are engaged in a review of the existing capacity of flood defenses and the drainage systems in Torbay. To enhance the risk communication with the stakeholders, we adopted a high performance flood model to analyse the flood risk to Cis under a wide range of scenarios. The results are integrated into an innovative 3D visualization tool, showing the progress over time of any flood scenario in the region, via a fully interactive interface allowing stakeholders to better understand flood impacts to CIs.The work presented in this paper was partially funded by the ongoing EC H2020 EU-CIRCLE (GA 653824) and the FP7 PEARL (Preparing for Extreme And Rare events in coastaL regions, GA 603663) projects

Cosmological Perturbations in a Big Crunch/Big Bang Space-time

A prescription is developed for matching general relativistic perturbations across singularities of the type encountered in the ekpyrotic and cyclic scenarios i.e. a collision between orbifold planes. We show that there exists a gauge in which the evolution of perturbations is locally identical to that in a model space-time (compactified Milne mod Z_2) where the matching of modes across the singularity can be treated using a prescription previously introduced by two of us. Using this approach, we show that long wavelength, scale-invariant, growing-mode perturbations in the incoming state pass through the collision and become scale-invariant growing-mode perturbations in the expanding hot big bang phase.Comment: 47 pages, 4 figure

Long-wavelength approximation for string cosmology with barotropic perfect fluid

The field equations derived from the low energy string effective action with a matter tensor describing a perfect fluid with a barotropic equation of state are solved iteratively using the long-wavelength approximation, i.e. the field equations are expanded by the number of spatial gradients. In the zero order, a quasi-isotropic solution is presented and compared with the general solution of the pure dilaton gravity. Possible cosmological models are analyzed from the point of view of the pre-big bang scenario. The second order solutions are found and their growing and decaying parts are studied.Comment: 19 pages, 1 figur

Generalizing Galileons

The Galileons are a set of terms within four-dimensional effective field theories, obeying symmetries that can be derived from the dynamics of a 3+1-dimensional flat brane embedded in a 5-dimensional Minkowski Bulk. These theories have some intriguing properties, including freedom from ghosts and a non-renormalization theorem that hints at possible applications in both particle physics and cosmology. In this brief review article, we will summarize our attempts over the last year to extend the Galileon idea in two important ways. We will discuss the effective field theory construction arising from co-dimension greater than one flat branes embedded in a flat background - the multiGalileons - and we will then describe symmetric covariant versions of the Galileons, more suitable for general cosmological applications. While all these Galileons can be thought of as interesting four-dimensional field theories in their own rights, the work described here may also make it easier to embed them into string theory, with its multiple extra dimensions and more general gravitational backgrounds.Comment: 16 pages; invited brief review article for a special issue of Classical and Quantum Gravity. Submitted to CQ