Problems of innovative receptivity of personnel of enterprises of industrial automation

Стаття присвячена аналізу галузі промислової автоматики (ПА), позначенню та з’ясовуванню проблематики у підприємств ПА для поліпшення інноваційної діяльності (ІД) шляхом комплексного підвищення інноваційної сприйнятливості (ІС) персоналу в системі управління персоналом. Показана динаміка виробничих економічних показників українських підприємств ПА за 2011-2017 рр., запропоновані рекомендації по підвищенню ІС персоналу. Наведено аналіз техніко-економічних показників підприємств ПА. Приведений загальний огляд реалізації продукції (товарів, послуг за видами економічної діяльності) на Україні за період 2010-2017 рр. Для дослідження приведена методологія порівняльного аналізу. Результати дослідження показують виявлення проблем підприємств ПA, які полягають у збільшенні реалізованої продукції і зниженні прибутку, що говорить про необхідність підвищення IС персоналу в системі управління персоналом.The article is devoted to the analysis of industrial areas in particular the field of industrial automation (ІA), the identification and clarification of problems in PA enterprises, to improve innovation activity (IА) through a comprehensive increase in the innovative receptivity (IR) of personnel in the personnel management system. The industrial enterprises of Ukraine and in particular industry of ІА now experiences heavy times of competitive activity with foreign companies and in particular with more cheap commodities from China. Not to lose the positions and occupy new markets it is needed not only to watch after novelties in the field of productive but also in the sphere of personnel and increase of him ІR for the increase of competitiveness. The dynamics of the production of economic indicators of the Ukrainian enterprises of IA for 2011-2017 is shown, recommendations for increasing the executive personnel are offered. The analysis of technical and economic indicators of IA enterprises is given. And also provides a general overview of the sale of products (goods, services by type of economic activity) in Ukraine for the period 2010-2017. For research methodology over of comparative analysis is brought. Research results are exposures of problems of enterprises of IA such as an increase of the realized products and decline of profit, that talks at the necessity of increase of IR of personnel, in control system by a personnel. Innovative activity of every enterprise of industrial automation (IA) is important for the increase of competitiveness and increase arrived. The innovative oriented skilled personnel failing in the Ukrainian enterprises, what called to provide development and increase of efficiency of activity of enterprises. For development normatively of technical documentation on a management and development of personnel experience of front-rank world companies is poorly used what track is adapted to take into account taking into account Ukrainian realities. To the necessity of development of control system by a personnel with the purpose of leading to of them to the standards of front-rank world companies

Regular and chaotic interactions of two BPS dyons at low energy

We identify and analyze quasiperiodic and chaotic motion patterns in the time evolution of a classical, non-Abelian Bogomol'nyi-Prasad-Sommerfield (BPS) dyon pair at low energies. This system is amenable to the geodesic approximation which restricts the underlying SU(2) Yang-Mills-Higgs dynamics to an eight-dimensional phase space. We numerically calculate a representative set of long-time solutions to the corresponding Hamilton equations and analyze quasiperiodic and chaotic phase space regions by means of Poincare surfaces of section, high-resolution power spectra and Lyapunov exponents. Our results provide clear evidence for both quasiperiodic and chaotic behavior and characterize it quantitatively. Indications for intermittency are also discussed.Comment: 22 pages, 6 figures (v2 contains a few additional references, a new paragraph on intermittency and minor stylistic corrections to agree with the published version

CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial

Background Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect tamoxifen efficacy. In this study, we investigated the clinical relevance of CYP2D6 polymorphisms. Methods We obtained tumor tissues and isolated DNA from 4861 of 8010 postmenopausal women with hormone receptor-positive breast cancer who enrolled in the randomized, phase III double-blind Breast International Group (BIG) 1-98 trial between March 1998 and May 2003 and received tamoxifen and/or letrozole treatment. Extracted DNA was used for genotyping nine CYP2D6 single-nucleotide polymorphisms using polymerase chain reaction-based methods. Genotype combinations were used to categorize CYP2D6 metabolism phenotypes as poor, intermediate, and extensive metabolizers (PM, IM, and EM, respectively; n = 4393 patients). Associations of CYP2D6 metabolism phenotypes with breast cancer-free interval (referred to as recurrence) and treatment-induced hot flushes according to randomized endocrine treatment and previous chemotherapy were assessed. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results No association between CYP2D6 metabolism phenotypes and breast cancer-free interval was observed among patients who received tamoxifen monotherapy without previous chemotherapy (P = .35). PM or IM phenotype had a non-statistically significantly reduced risk of breast cancer recurrence compared with EM phenotype (PM or IM vs EM, HR of recurrence = 0.86, 95% CI = 0.60 to 1.24). CYP2D6 metabolism phenotype was associated with tamoxifen-induced hot flushes (P = .020). Both PM and IM phenotypes had an increased risk of tamoxifen-induced hot flushes compared with EM phenotype (PM vs EM, HR of hot flushes = 1.24, 95% CI = 0.96 to 1.59; IM vs EM, HR of hot flushes = 1.23, 95% CI = 1.05 to 1.43). Conclusions CYP2D6 phenotypes of reduced enzyme activity were not associated with worse disease control but were associated with increased hot flushes, contrary to the hypothesis. The results of this study do not support using the presence or absence of hot flushes or the pharmacogenetic testing of CYP2D6 to determine whether to treat postmenopausal breast cancer patients with tamoxife

Fur in Magnetospirillum gryphiswaldense Influences Magnetosomes Formation and Directly Regulates the Genes Involved in Iron and Oxygen Metabolism

Magnetospirillum gryphiswaldense strain MSR-1 has the unique capability of taking up large amounts of iron and synthesizing magnetosomes (intracellular magnetic particles composed of Fe3O4). The unusual high iron content of MSR-1 makes it a useful model for studying biological mechanisms of iron uptake and homeostasis. The ferric uptake regulator (Fur) protein plays a key role in maintaining iron homeostasis in many bacteria. We identified and characterized a fur-homologous gene (MGR_1314) in MSR-1. MGR_1314 was able to complement a fur mutant of E. coli in iron-responsive manner in vivo. We constructed a fur mutant strain of MSR-1. In comparison to wild-type MSR-1, the mutant strain had lower magnetosome formation, and was more sensitive to hydrogen peroxide and streptonigrin, indicating higher intracellular free iron content. Quantitative real-time RT-PCR and chromatin immunoprecipitation analyses indicated that Fur protein directly regulates expression of several key genes involved in iron transport and oxygen metabolism, in addition it also functions in magnetosome formation in M. gryphiswaldense

Prospective Environmental Life Cycle Assessment of Nanosilver T-Shirts

A cradle-to-grave life cycle assessment (LCA) is performed to compare nanosilver T-shirts with conventional T-shirts with and without biocidal treatment. For nanosilver production and textile incorporation, we investigate two processes: flame spray pyrolysis (FSP) and plasma polymerization with silver co-sputtering (PlaSpu). Prospective environmental impacts due to increased nanosilver T-shirt commercialization are estimated with six scenarios. Results show significant differences in environmental burdens between nanoparticle production technologies: The "cradle-to-gate" climate footprint of the production of a nanosilver T-shirt is 2.70 kg of CO2-equiv (FSP) and 7.67-166 kg of CO2-equiv (PlaSpu, varying maturity stages). Production of conventional T-shirts with and without the biocide triclosan has emissions of 2.55 kg of CO2-equiv (contribution from triclosan insignificant). Consumer behavior considerably affects the environmental impacts during the use phase. Lower washing frequencies can compensate for the increased climate footprint of FSP nanosilver T-shirt production. The toxic releases from washing and disposal in the life cycle of T-shirts appear to be of minor relevance. By contrast, the production phase may be rather significant due to toxic silver emissions at the mining site if high silver quantities are require