A Review on use of Mistake Proof (Poka Yoke) Locating Fixture on Ultra SD Cartridge Assembly Line

Manufacturing defects are the major concern of all manufacturing industries. These defects occur due to poor material quality or lack of skilled labour. This paper focuses upon one such operation that was dependent on the skills of the operator which was deskilled by one of the successful devices in lean production which is used to eliminate waste caused by errors i.e ‘mistake-proofing' or ‘Poka-yoke'. The use of Poka Yoke in the Ultra SD Cartridge assembly operation eliminated the requirement of skilled operator. This was effectively done by introducing a new locating fixture on the assembly line

Searching and fixating: scale-invariance vs. characteristic timescales in attentional processes

In an experiment involving semantic search, the visual movements of sample populations subjected to visual and aural input were tracked in a taskless paradigm. The probability distributions of saccades and fixations were obtained and analyzed. Scale-invariance was observed in the saccadic distributions, while the fixation distributions revealed the presence of a characteristic (attentional) time scale for literate subjects. A detailed analysis of our results suggests that saccadic eye motions are an example of Levy, rather than Brownian, dynamics.Comment: Accepted to Europhysics Letters (2011

Carbon Nanotubes Based Porous Framework for Filtration Applications Using Industrial Grinding Waste

Forging, milling, turning, grinding and shaping etc. are the various industrial manufacturing processes which generate the metal waste. Grinding is extensively used in the finishing operation. The waste generated contains significant impurities apart from the metal particles. Due to these significant impurities, it becomes difficult to process and gets usually dumped in the landfills which create environmental problems. Therefore, it becomes essential to reuse metal waste to create value added products. Powder injection molding process is used for producing the porous metal matrix framework. This paper discusses the presented design of the porous framework to be used for the liquid filter application. Different parameters are optimized to obtain the better strength framework with variable porosity. Carbon nanotubes are used as reinforcing materials to enhance the strength of the metal matrix framework

Temperature dependent optical studies of Ti1−x_{1-x}Cox_xO2_2

We present the results of Raman and photoluminescence (PL) studies on epitaxial anatase phase Ti$_{1-x}$Co$_x$O$_2$ films for $x$ = 0-0.07, grown by pulsed laser deposition. The low doped system ($x$=0.01 and 0.02) shows a Curie temperature of ~700 K in the as-grown state. The Raman spectra from the doped and undoped films confirm their anatase phase. The photoluminescence spectrum is characterized by a broad emission from self-trapped excitons (STE) at 2.3 eV at temperatures below 120 K. This peak is characteristic of the anatase-phase TiO$_2$ and shows a small blueshift with increasing doping concentration. In addition to the emission from STE, the Co-doped samples show two emission lines at 2.77 eV and 2.94 eV that are absent in the undoped film indicative of a spin-flip energy.Comment: 8 pages, 4 figure

Effect of pharmacovigilance training programme on quantitative and qualitative adverse drug reaction reporting

Background: Adverse Drug Reactions(ADRs) are required to monitored in post marketing phase for unstudied ADR or beneficial effect which were not evident in controlled study design, but ADRs are usually under reported due to misbelieves or ignorance of health care worker. There is increasing numbers of adverse drug reaction monitoring centers in India affiliated to governing council but are in primitive phase. Also, there is lack of knowledge and attitude towards necessity for proper reporting of ADR, understanding of terminologies. Hence present study was undertaken to assess out of educational intervention in the form of simulated ADR workshop.Methods: Hundred nursing staff of JNMC were trained through Simulation Workshop i.e. initial knowledge as assessed before intervention, followed by explanations of every terminology essential for quality reporting of ADR. Ideal ADR reports were provided for study and ADR scenario was given for reporting of ADR. Deficiencies in reported ADR explained to participants. Post intervention knowledge and reporting was assessed. Deficiencies in actual ADR were pursued for three months.Results: There was statistically significant improvement observed in knowledge (p <0.01) and corresponding, proportionate quality parameters of ADRs as suggested by Z test.Conclusions: Educational intervention through simulated ADR and understanding about significance of ADR reporting’s and related terminologies improves quality as well as numbers of ADR reporting

TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death

Emerging evidence suggests that ubiquitin mediated post translational modification is a critical regulatory process involved in diverse cellular pathways including cell death. During ubiquitination, E3 ligases recognize target proteins and determine the topology of ubiquitin chains. Recruitment of E3 ligases to targets proteins under stress conditions including oxidative stress and their implication in cell death have not been systemically explored. In the present study, we characterized the role of TRIM32 as an E3 ligase in regulation of oxidative stress induced cell death. TRIM32 is ubiquitously expressed in cell lines of different origin and form cytoplasmic speckle like structures that transiently interact with mitochondria under oxidative stress conditions. The ectopic expression of TRIM32 sensitizes cell death induced by oxidative stress whereas TRIM32 knockdown shows a protective effect. The turnover of TRIM32 is enhanced during oxidative stress and its expression induces ROS generation, loss of mitochondrial transmembrane potential and decrease in complex-I activity. The pro-apoptotic effect was rescued by pan-caspase inhibitor or antioxidant treatment. E3 ligase activity of TRIM32 is essential for oxidative stress induced apoptotic cell death. Furthermore, TRIM32 decreases X-linked inhibitor of apoptosis (XIAP) level and overexpression of XIAP rescued cells from TRIM32 mediated oxidative stress and cell death. Overall, the results of this study provide the first evidence supporting the role of TRIM32 in regulating oxidative stress induced cell death, which has implications in numerous pathological conditions including cancer and neurodegeneration

Superconducting MgB2 thin films by pulsed laser deposition

Growth of MgB2 thin films by pulsed laser deposition is examined under ex situ and in situ processing conditions. For the ex situ process, Boron films grown by PLD were annealed at 900 C with excess Mg. For the in situ process, different approaches involving ablation from a stoichiometric target under different growth conditions, as well as multilayer deposition involving interposed Mg layers were examined and analyzed. Magnetic measurements on ex situ processed films show TC of ~39 K, while the current best in situ films show a susceptibility transition at ~ 22 K.Comment: 3 pages, PD