Vaccine-preventable haemophilus influenza type B disease burden and cost-effectiveness of infant vaccination in Indonesia.

BACKGROUND: Most of Asia, including Indonesia, does not use Haemophilus influenzae type b (Hib) conjugate vaccines. We estimated total vaccine-preventable disease burden and the cost-effectiveness of Hib conjugate vaccine in Indonesia. METHODS: Hib pneumonia and meningitis incidences for children with access to health care were derived from a randomized vaccine probe study on Lombok Island, Indonesia during 1998-2002. Incidences were adjusted for limited access to care. Health system and patient out-of-pocket treatment cost data were collected concurrent with the probe study. For Hib vaccine in monovalent and combined (with DTP-HepB) presentations, we used 2007 UNICEF vaccine prices of US$3.30 and$3.75 per dose. RESULTS: For the 2007 Indonesian birth cohort, Hib vaccine would prevent meningitis in 1 of every 179 children, pneumonia in 1 of every 18 children, and 4.9% of mortality among those younger than 5 years. The total incremental societal costs of introducing Hib vaccine in monovalent and pentavalent presentations were, respectively, US$11.74 and$8.93 per child vaccinated. Annual discounted treatment costs averted amounted to 20% of pentavalent vaccine costs. For the pentavalent vaccine, the incremental costs per discounted death and disability adjusted life-year averted amounted to US$3102 and$74, respectively, versus $4438 and$102 for monovalent vaccine. CONCLUSIONS: Routine infant Hib vaccination would prevent a large burden of pediatric illness and death in Indonesia. Even without external funding support, Hib vaccine will be a highly cost-effective intervention in either a monovalent or pentavalent presentation based on commonly used benchmarks

Three-dimensional Models of Core-collapse Supernovae From Low-mass Progenitors With Implications for Crab

We present 3D full-sphere supernova simulations of non-rotating low-mass (~9 Msun) progenitors, covering the entire evolution from core collapse through bounce and shock revival, through shock breakout from the stellar surface, until fallback is completed several days later. We obtain low-energy explosions [~(0.5-1.0)x 10^{50} erg] of iron-core progenitors at the low-mass end of the core-collapse supernova (LMCCSN) domain and compare to a super-AGB (sAGB) progenitor with an oxygen-neon-magnesium core that collapses and explodes as electron-capture supernova (ECSN). The onset of the explosion in the LMCCSN models is modelled self-consistently using the Vertex-Prometheus code, whereas the ECSN explosion is modelled using parametric neutrino transport in the Prometheus-HOTB code, choosing different explosion energies in the range of previous self-consistent models. The sAGB and LMCCSN progenitors that share structural similarities have almost spherical explosions with little metal mixing into the hydrogen envelope. A LMCCSN with less 2nd dredge-up results in a highly asymmetric explosion. It shows efficient mixing and dramatic shock deceleration in the extended hydrogen envelope. Both properties allow fast nickel plumes to catch up with the shock, leading to extreme shock deformation and aspherical shock breakout. Fallback masses of <~5x10^{-3} Msun have no significant effects on the neutron star (NS) masses and kicks. The anisotropic fallback carries considerable angular momentum, however, and determines the spin of the newly-born NS. The LMCCSNe model with less 2nd dredge-up results in a hydrodynamic and neutrino-induced NS kick of >40 km/s and a NS spin period of ~30 ms, both not largely different from those of the Crab pulsar at birth.Comment: 47 pages, 27 figures, 6 tables; minor revisions, accepted by MNRA

Local Detection of Quantum Correlations with a Single Trapped Ion

As one of the most striking features of quantum mechanics, quantum correlations are at the heart of quantum information science. Detection of correlations usually requires access to all the correlated subsystems. However, in many realistic scenarios this is not feasible since only some of the subsystems can be controlled and measured. Such cases can be treated as open quantum systems interacting with an inaccessible environment. Initial system-environment correlations play a fundamental role for the dynamics of open quantum systems. Following a recent proposal, we exploit the impact of the correlations on the open-system dynamics to detect system-environment quantum correlations without accessing the environment. We use two degrees of freedom of a trapped ion to model an open system and its environment. The present method does not require any assumptions about the environment, the interaction or the initial state and therefore provides a versatile tool for the study of quantum systems.Comment: 6 Pages, 5 Figures + 6 Pages, 1 Figure of Supplementary Materia

Can Galactic Observations Be Explained by a Relativistic Gravity Theory?

We consider the possibility of an alternative gravity theory explaining the dynamics of galactic systems without dark matter. From very general assumptions about the structure of a relativistic gravity theory we derive a general expression for the metric to order $(v/c)^2$. This allows us to compare the predictions of the theory with various experimental data: the Newtonian limit, light deflection and retardation, rotation of galaxies and gravitational lensing. Our general conclusion is that the possibility for any gravity theory to explain the behaviour of galaxies without dark matter is rather improbable.Comment: 12p, REVTeX 3.

The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia : further evidence and meta-analysis

NO is a pleiotropic signaling molecule and has an important role in cognition and emotion. In the brain, NO is produced by neuronal nitric oxide synthase (NOS-I, encoded by NOS1) coupled to the NMDA receptor via PDZ. interactions; this protein-protein interaction is disrupted upon binding of NOS1 adapter protein (encoded by NOS1AP) to NOS-I. As both NOS1 and NOS1AP were associated with schizophrenia, we here investigated these genes in greater detail by genotyping new samples and conducting a meta-analysis of our own and published data. In doing so, we confirmed association of both genes with schizophrenia and found evidence for their interaction in increasing risk towards disease. Our strongest finding was the NOS1 promoter SNP rs41279104, yielding an odds ratio of 1.29 in the meta-analysis. As findings from heterologous cell systems have suggested that the risk allele decreases gene expression, we studied the effect of the variant on NOS1 expression in human post-mortem brain samples and found that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex. Bioinformatic analyses suggest that this might be due the replacement of six transcription factor binding sites by two new binding sites as a consequence of proxy SNPs. Taken together, our data argue that genetic variance in NOS1 resulting in lower prefrontal brain expression of this gene contributes to schizophrenia liability, and that NOS1 interacts with NOS1AP in doing so. The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia. PostprintPeer reviewe

Three-dimensional models of core-collapse supernovae from low-mass progenitors with implications for Crab

We present 3D full-sphere supernova simulations of non-rotating low-mass (∼9 M_⊙) progenitors, covering the entire evolution from core collapse through bounce and shock revival, through shock breakout from the stellar surface, until fallback is completed several days later. We obtain low-energy explosions (∼0.5–1.0 × 10⁵⁰ erg) of iron-core progenitors at the low-mass end of the core-collapse supernova (LMCCSN) domain and compare to a super-AGB (sAGB) progenitor with an oxygen–neon–magnesium core that collapses and explodes as electron-capture supernova (ECSN). The onset of the explosion in the LMCCSN models is modelled self-consistently using the VERTEX-PROMETHEUS code, whereas the ECSN explosion is modelled using parametric neutrino transport in the PROMETHEUS-HOTB code, choosing different explosion energies in the range of previous self-consistent models. The sAGB and LMCCSN progenitors that share structural similarities have almost spherical explosions with little metal mixing into the hydrogen envelope. A LMCCSN with less second dredge-up results in a highly asymmetric explosion. It shows efficient mixing and dramatic shock deceleration in the extended hydrogen envelope. Both properties allow fast nickel plumes to catch up with the shock, leading to extreme shock deformation and aspherical shock breakout. Fallback masses of ≲ 5×10⁻³ M_⊙ have no significant effects on the neutron star (NS) masses and kicks. The anisotropic fallback carries considerable angular momentum, however, and determines the spin of the newly born NS. The LMCCSN model with less second dredge-up results in a hydrodynamic and neutrino-induced NS kick of >40 km s⁻¹ and a NS spin period of ∼30 ms, both not largely different from those of the Crab pulsar at birth

Entanglement distribution and quantum discord

Establishing entanglement between distant parties is one of the most important problems of quantum technology, since long-distance entanglement is an essential part of such fundamental tasks as quantum cryptography or quantum teleportation. In this lecture we review basic properties of entanglement and quantum discord, and discuss recent results on entanglement distribution and the role of quantum discord therein. We also review entanglement distribution with separable states, and discuss important problems which still remain open. One such open problem is a possible advantage of indirect entanglement distribution, when compared to direct distribution protocols.Comment: 7 pages, 2 figures, contribution to "Lectures on general quantum correlations and their applications", edited by Felipe Fanchini, Diogo Soares-Pinto, and Gerardo Adess

Identification of Streptococcus suis Meningitis through Population-Based Surveillance, Togo, 2010-2014.

During 2010-2014, we enrolled 511 patients with suspected bacterial meningitis into surveillance in 2 districts of northern Togo. We identified 15 persons with Streptococcus suis infection; 10 had occupational contact with pigs, and 12 suffered neurologic sequelae. S. suis testing should be considered in rural areas of the African meningitis belt