3,223 research outputs found
"The Financially Fragile Firm: Is There a Case for It in the 1920s?"
This paper is an empirical investigation of Minsky's hypothesis in the U.S. consumer durables sector during the 1920s. The first section of the paper briefly describes Minsky's financial fragility hypothesis, while the second sketches a brief economic historical background of the 1920s in the U.S. The third section introduces the methodology utilized and the fourth presents the results of the analysis. In the conclusion the findings and their implications are summarized.
Cancer complicating systemic lupus erythematosus--a dichotomy emerging from a nested case-control study
We determined whether any individual cancers are increased or decreased in a cohort of 595 patients with systemic lupus erythematosus (SLE) followed for up to 32 years at the University College London Hospitals Lupus Clinic, looking for any associated clinical or serological factors and the prognosis after cancer diagnosis
A model problem for conformal parameterizations of the Einstein constraint equations
We investigate the possibility that the conformal and conformal thin sandwich
(CTS) methods can be used to parameterize the set of solutions of the vacuum
Einstein constraint equations. To this end we develop a model problem obtained
by taking the quotient of certain symmetric data on conformally flat tori.
Specializing the model problem to a three-parameter family of conformal data we
observe a number of new phenomena for the conformal and CTS methods. Within
this family, we obtain a general existence theorem so long as the mean
curvature does not change sign. When the mean curvature changes sign, we find
that for certain data solutions exist if and only if the transverse-traceless
tensor is sufficiently small. When such solutions exist, there are generically
more than one. Moreover, the theory for mean curvatures changing sign is shown
to be extremely sensitive with respect to the value of a coupling constant in
the Einstein constraint equations.Comment: 40 pages, 4 figure
A study of electronic packages environmental control systems and vehicle thermal systems integration Quarterly report, Nov. 1966 - Jan. 1967
Heat balances of combined astrionic equipment and thermal conditioning subsystem of environmental control system, and vehicle configuration
A non-existence result for a generalization of the equations of the conformal method in general relativity
The constraint equations of general relativity can in many cases be solved by
the conformal method. We show that a slight modification of the equations of
the conformal method admits no solution for a broad range of parameters. This
suggests that the question of existence or non-existence of solutions to the
original equations is more subtle than could perhaps be expected.Comment: minor changes from previous versio
Asymptotically Hyperbolic Non Constant Mean Curvature Solutions of the Einstein Constraint Equations
We describe how the iterative technique used by Isenberg and Moncrief to
verify the existence of large sets of non constant mean curvature solutions of
the Einstein constraints on closed manifolds can be adapted to verify the
existence of large sets of asymptotically hyperbolic non constant mean
curvature solutions of the Einstein constraints.Comment: 19 pages, TeX, no figure
Anti-IFNαR Mabs for the treatment of systemic lupus erythematosus
INTRODUCTION: The type 1 interferon pathway is known to play a role in the immunopathology of systemic lupus erythematosus (SLE). As a result, biologic agents targeting this pathway have been developed and are currently being investigated in clinical trials. AREAS COVERED: We review the biologic agents which have been developed to antagonize type I interferons in SLE. We focus on anifrolumab, a type I interferon receptor antagonist, and consider the complexities of defining efficacy in SLE clinical trials. EXPERT OPINION: Anifrolumab shows promise as an addition to the SLE therapeutic armamentarium. Despite discordant results between its two phase III studies, there is a convincing suggestion of benefit in both trials to encourage the view that this approach might be effective. Data acquired thus far look particularly useful for cutaneous disease. We await data on its effect on renal, pulmonary, cardiac, and central nervous system involvement, on patient reported outcomes, and its safety and efficacy with long-term use
Resonant Interactions Between Protons and Oblique Alfv\'en/Ion-Cyclotron Waves
Resonant interactions between ions and Alfv\'en/ion-cyclotron (A/IC) waves
may play an important role in the heating and acceleration of the fast solar
wind. Although such interactions have been studied extensively for "parallel"
waves, whose wave vectors are aligned with the background magnetic
field , much less is known about interactions between ions and
oblique A/IC waves, for which the angle between and is nonzero. In this paper, we present new numerical results on resonant
cyclotron interactions between protons and oblique A/IC waves in collisionless
low-beta plasmas such as the solar corona. We find that if some mechanism
generates oblique high-frequency A/IC waves, then these waves initially modify
the proton distribution function in such a way that it becomes unstable to
parallel waves. Parallel waves are then amplified to the point that they
dominate the wave energy at the large parallel wave numbers at which the waves
resonate with the particles. Pitch-angle scattering by these waves then causes
the plasma to evolve towards a state in which the proton distribution is
constant along a particular set of nested "scattering surfaces" in velocity
space, whose shapes have been calculated previously. As the distribution
function approaches this state, the imaginary part of the frequency of parallel
A/IC waves drops continuously towards zero, but oblique waves continue to
undergo cyclotron damping while simultaneously causing protons to diffuse
across these kinetic shells to higher energies. We conclude that oblique A/IC
waves can be more effective at heating protons than parallel A/IC waves,
because for oblique waves the plasma does not relax towards a state in which
proton damping of oblique A/IC waves ceases
The constraint equations for the Einstein-scalar field system on compact manifolds
We study the constraint equations for the Einstein-scalar field system on
compact manifolds. Using the conformal method we reformulate these equations as
a determined system of nonlinear partial differential equations. By introducing
a new conformal invariant, which is sensitive to the presence of the initial
data for the scalar field, we are able to divide the set of free conformal data
into subclasses depending on the possible signs for the coefficients of terms
in the resulting Einstein-scalar field Lichnerowicz equation. For many of these
subclasses we determine whether or not a solution exists. In contrast to other
well studied field theories, there are certain cases, depending on the mean
curvature and the potential of the scalar field, for which we are unable to
resolve the question of existence of a solution. We consider this system in
such generality so as to include the vacuum constraint equations with an
arbitrary cosmological constant, the Yamabe equation and even (all cases of)
the prescribed scalar curvature problem as special cases.Comment: Minor changes, final version. To appear: Classical and Quantum
Gravit
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