33 research outputs found
Sufficient Conditions for Fast Switching Synchronization in Time Varying Network Topologies
In previous work, empirical evidence indicated that a time-varying network
could propagate sufficient information to allow synchronization of the
sometimes coupled oscillators, despite an instantaneously disconnected
topology. We prove here that if the network of oscillators synchronizes for the
static time-average of the topology, then the network will synchronize with the
time-varying topology if the time-average is achieved sufficiently fast. Fast
switching, fast on the time-scale of the coupled oscillators, overcomes the
descychnronizing decoherence suggested by disconnected instantaneous networks.
This result agrees in spirit with that of where empirical evidence suggested
that a moving averaged graph Laplacian could be used in the master-stability
function analysis. A new fast switching stability criterion here-in gives
sufficiency of a fast-switching network leading to synchronization. Although
this sufficient condition appears to be very conservative, it provides new
insights about the requirements for synchronization when the network topology
is time-varying. In particular, it can be shown that networks of oscillators
can synchronize even if at every point in time the frozen-time network topology
is insufficiently connected to achieve synchronization.Comment: Submitted to SIAD
Why organizational and community diversity matter:Representativeness and the Emergence of Incivility and Organizational Performance
Integrating sociological and psychological perspectives, this research considers the value of organizational ethnic diversity as a function of community diversity. Employee and patient surveys, census data, and performance indexes relevant to 142 hospitals in the United Kingdom suggest that intraorganizational ethnic diversity is associated with reduced civility toward patients. However, the degree to which organizational demography was representative of community demography was positively related to civility experienced by patients and ultimately enhanced organizational performance. These findings underscore the understudied effects of community context and imply that intergroup biases manifested in incivility toward out-group members hinder organizational performance
Attitudes toward relationship treatment among underserved couples
Attitudinal and instrumental barriers exist for couples broadly that prevent couples from accessing professional relationship help. These barriers may be even more pronounced among couples from low-income, and other underserved, backgrounds. The current study examined how couples\u27 (N = 651 couples) presenting attitudes toward seeking couple treatment, and change in these attitudes, differed as a function of demographic variables within a brief relationship education program, Relationship Checkup (Gordon et al., 2020). Results revealed that individuals who identified as male, a person of color, had lower income, or were cohabiting evidenced poorer baseline attitudes relative to their demographic counterparts. Further, people of color and people who were cohabiting evidenced greater change in attitudes across the intervention relative to their demographic counterparts. Thus, clinicians may benefit from considering that underserved couples appear to face attitudinal barriers in addition to known instrumental barriers (e.g., financial, transportation, childcare, time, etc.). Clinical and research implications are discussed
Accelerated Ageing Kinetics of Pure Cellulose Paper after Washing, Alkalization and Impregnation with Methylcellulose
Cotton Cellulose Ageing in Sealed Vessels. Kinetic Model of Autocatalytic Depolymerization
Undernutrition and Risk of Mortality in Elderly Patients Within 1 Year of Hospital Discharge
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Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.
We assessed the results of genome sequencing for early-onset dementia. Participants were selected from a memory disorders clinic. Genome sequencing was performed along with C9orf72 repeat expansion testing. All returned sequencing results were Sanger-validated. Prior clinical diagnoses included Alzheimer's disease, frontotemporal dementia, and unspecified dementia. The mean age of onset was 54 (41-76). Fifty percent of patients had a strong family history, 37.5% had some, and 12.5% had no known family history. Nine of 32 patients (28%) had a variant defined as pathogenic or likely pathogenic (P/LP) by American College of Medical Genetics and Genomics standards, including variants in APP, C9orf72, CSF1R, and MAPT Nine patients (including three with P/LP variants) harbored established risk alleles with moderate penetrance (odds ratios of ∼2-5) in ABCA7, AKAP9, GBA, PLD3, SORL1, and TREM2 All six patients harboring these moderate penetrance variants but not P/LP variants also had one or two APOE ε4 alleles. One patient had two APOE ε4 alleles with no other established contributors. In total, 16 patients (50%) harbored one or more genetic variants likely to explain symptoms. We identified variants of uncertain significance (VUSs) in ABI3, ADAM10, ARSA, GRID2IP, MME, NOTCH3, PLCD1, PSEN1, TM2D3, TNK1, TTC3, and VPS13C, also often along with other variants. In summary, genome sequencing for early-onset dementia frequently identified multiple established or possible contributory alleles. These observations add support for an oligogenic model for early-onset dementia
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Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles.
We assessed the results of genome sequencing for early-onset dementia. Participants were selected from a memory disorders clinic. Genome sequencing was performed along with C9orf72 repeat expansion testing. All returned sequencing results were Sanger-validated. Prior clinical diagnoses included Alzheimer's disease, frontotemporal dementia, and unspecified dementia. The mean age of onset was 54 (41-76). Fifty percent of patients had a strong family history, 37.5% had some, and 12.5% had no known family history. Nine of 32 patients (28%) had a variant defined as pathogenic or likely pathogenic (P/LP) by American College of Medical Genetics and Genomics standards, including variants in APP, C9orf72, CSF1R, and MAPT Nine patients (including three with P/LP variants) harbored established risk alleles with moderate penetrance (odds ratios of ∼2-5) in ABCA7, AKAP9, GBA, PLD3, SORL1, and TREM2 All six patients harboring these moderate penetrance variants but not P/LP variants also had one or two APOE ε4 alleles. One patient had two APOE ε4 alleles with no other established contributors. In total, 16 patients (50%) harbored one or more genetic variants likely to explain symptoms. We identified variants of uncertain significance (VUSs) in ABI3, ADAM10, ARSA, GRID2IP, MME, NOTCH3, PLCD1, PSEN1, TM2D3, TNK1, TTC3, and VPS13C, also often along with other variants. In summary, genome sequencing for early-onset dementia frequently identified multiple established or possible contributory alleles. These observations add support for an oligogenic model for early-onset dementia