Influence of phosphorus supplements upon cellulose digestion by ruman microorganisms and ration digestibility by sheep

Since phosphorus has been found to be of vital importance for rumen bacteria and since there are a large number of phosphorus supplements available for feed use, this study was undertaken for the following purposes: 1. To determine the effects of phosphorus from dicalcium phosphate (furnace process), dicalcium phosphate (vet acid process), Curaco rock phosphate and a defluorinated phosphate upon cellulose digestion by rumen microorganisms In vitro. 2. To compare the relative availability of these four sources of phosphorus. 3. To compare the relative availability of the four sources of phosphorus to rumen microorganisms collected from a steer on pasture and to rumen microorganism from a steer on dry feed. 4. To determine the effect of an adaption period on the availability of a phosphorus supplement to rumen microbes. 5. To compare the relative availability of three defluorinated phosphates obtained from three different sources. 6. To determine the effect of phosphorus from a dicalcium phosphate supplement and a defluorinated phosphate supplement upon cellulose digestion by sheep

Process Optimization By Flow Sheet Simulation

Optimization of large or complex chemical processes often requires simplifying the system to reduce the mathematics to a form manageable by available algorithms or to reduce the time required to perform the computations. In many cases, such simplification alters the solution of the problem. Flow sheet simulation programs are ideally suited to the study of chemical processes, although the computational time is generally considered excessive for detailed optimization of complex systems by the usual procedures. This paper discusses the modifications needed to apply flow sheet simulation programs to the optimization of chemical processes. The advantages and disadvantages of the use of several optimization algorithms, including stochastic procedures, in this modified program are discussed and examples compared. © 1976, American Chemical Society. All rights reserved

Association between genotypic diversity and biofilm production in group B Streptococcus

Background: Group B Streptococcus (GBS) is a leading cause of sepsis and meningitis and an important factor in premature and stillbirths. Biofilm production has been suggested to be important for GBS pathogenesis alongside many other elements, including phylogenetic lineage and virulence factors, such as pili and capsule type. A complete understanding of the confluence of these components, however, is lacking. To identify associations between biofilm phenotype, pilus profile and lineage, 293 strains from asymptomatic carriers, invasive disease cases, and bovine mastitis cases, were assessed for biofilm production using an in vitro assay. Results: Multilocus sequence type (ST) profile, pilus island profile, and isolate source were associated with biofilm production. Strains from invasive disease cases and/or belonging to the ST-17 and ST-19 lineages were significantly more likely to form weak biofilms, whereas strains producing strong biofilms were recovered more frequently from individuals with asymptomatic colonization. Conclusions: These data suggest that biofilm production is a lineage-specific trait in GBS and may promote colonization of strains representing lineages other than STs 17 and 19. The findings herein also demonstrate that biofilms must be considered in the treatment of pregnant women, particularly for women with heavy GBS colonization

An Examination Of The Adaptive Random Search Technique

Random search procedures have recently been successfully applied to the optimization of a variety of chemical engineering problems, including optimization of chemical processes by flow sheet simulation. These procedures represent the independent variables as random variables described by probability distributions. The adaptive random search procedure centers the distribution for each variable about the best search point found and examines this region for a better point. Thus, this technique has the ability of continuously moving the search region toward the optimum, which is particularly advantageous in following constraints. This study examines the efficiency of the adaptive random search technique as applied to six different problems, which have been previously solved by various other techniques. Copyright © 1976 American Institute of Chemical Engineer

The Relationship between Sex-role Identification and Personal Adjustment of College Males

The purpose of the present study was to determine the relationship between masculine traits in males and the characteristic patterns of emotional responses which affect social adjustment

Energy from Agriculture

During the past few years, the demand for energy and petrochemicals has grown at a pace so rapid that our reserves of fossil fuels, once considered inexhaustible, are now being quickly depleted. To help lessen this impending problem, alternative sources of energy must be rapidly developed. Of the many new sources of energy being studied, solar energy, undisputedly, is the most inexhaustible. Energy from the sun, incident upon the earth\u27s surface, exceeds by nearly three orders of magnitude the total energy consumption today. Furthermore, it is not subject to nationalistic boundaries and its use would be compatible with our environmental goals. Several methods of using solar energy are under investigation

Energy From Biochemical Sources

As available energy reserves decline, renewable sources must be utilized. Organic matter, grown agriculturally, represents a renewable energy source, which is readily available. This paper reviews the methods by which organic matter can be converted to energy sources by biochemical processes. The economics of conversion of agricultural crops and byproducts to alcohols by fermentation and conversion of these agricultural materials to methane by anaerobic digestion are examined. Projections of the potential of this energy source are quite promising

Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination

Background: Immunization strategies that elicit antibodies capable of neutralizing diverse strains of the virus will likely be an important part of a successful vaccine against HIV. The envelope trimer is the only neutralizing target on the virus, and strategies to promote durable, high avidity antibody responses against the native intact trimer structure are lacking. We recently developed chemically-crosslinked lipid nanocapsules as carriers of molecular adjuvants and encapsulated or surface-displayed antigens, which promote follicular helper T-cell responses and elicited high-avidity, durable antibody responses to a candidate malaria antigen (Moon et al. Nat. Mater. 10 243 (2011); Moon et al. PNAS 109 1080 (2012)). Methods: To apply this system to the delivery of HIV antigens, we developed a strategy to anchor recombinant envelope trimers to the surfaces of these particles under conditions preserving the antigenic integrity of the trimers, allowing multivalent display of these immunogens for immunization. To anchor trimers in their native orientation, gp140 trimers with terminal his-tags were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids. Results: Owing to their significant size (409 kDa) and heavy glycosylation, we found that liquid-ordered and/or gel-phase lipid compositions were required to stably anchor trimers to particle membranes. Trimer-loaded nanocapsules carrying monophosphoryl lipid A elicited durable antibody responses with titers comparable to a Complete Freund’s Adjuvant (CFA)-like emulsion in mice, without the toxic inflammation associated with the latter adjuvant. Further, nanocapsules elicited strong helper T-cell responses associated with a steadily increasing avidity of trimer-binding antibody over 90 days, which was not replicated by other adjuvants. Conclusion: These results suggest that nanoparticles displaying HIV trimers in an oriented, multivalent presentation can promote key aspects of the humoral response against Env immunogens.National Institutes of Health (U.S.) (AI095109)Massachusetts Institute of Technology. Ragon Institute of MGH, MIT, and Harvar

A Systematic Approach to Preparing for Chemotherapy Administration

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68916/2/10.1177_104345429100800308.pd

Zee electrical interconnect

An interconnect, having some length, that reliably connects two conductors separated by the length of the interconnect when the connection is made but in which one length if unstressed would change relative to the other in operation. The interconnect comprises a base element an intermediate element and a top element. Each element is rectangular and formed of a conducting material and has opposed ends. The elements are arranged in a generally Z-shape with the base element having one end adapted to be connected to one conductor. The top element has one end adapted to be connected to another conductor and the intermediate element has its ends disposed against the other end of the base and the top element. Brazes mechanically and electrically interconnect the intermediate element to the base and the top elements proximate the corresponding ends of the elements. When the respective ends of the base and the top elements are connected to the conductors, an electrical connection is formed therebetween, and when the conductors are relatively moved or the interconnect elements change length the elements accommodate the changes and the associated compression and tension forces in such a way that the interconnect does not mechanically fatigue