Transferable Drug Resistance Among Enterobacteriaceae Isolated from Human Urinary Tract Infections

Fifteen sulfonamide-resistant cultures isolated from urinary tract infections in eastern Nebraska were screened for transferable drug resistance by three methods. Seven of the 15 resistant cultures could transfer resistance of varying levels to two or more chemotherapeutic agents. Transfer of drug resistance occurred without accompanying transfer of chromosomal traits and required cell to cell contact. In mixed culture, the number of drug-resistant recipients increased exponentially, reaching a plateau 2 hr after mixing. Spontaneous or artificial elimination of resistance was found to be a rare event. In addition, several drug-sensitive isolates from urinary tract infections were shown to be competent recipients of drug resistance determinants. From these data, it appears that the transferable drug resistance observed was mediated by R factors

Cellular requirements for antigen presentation in the induction of a thymus-independent antibody response in vitro.

We consider a rectilinear quasi-stationary motion of a two-mass system in a viscous medium. The motion of the system as a whole occurs due to periodic movements of the internal mass relatively to the shell. The problem is to describe the law of motion of the internal mass that provides the minimum energy consumption with a specified average velocity of the shell. We propose an algorithm for solving the problem with any law of the resistance of the medium. We obtain the energy-optimal law of motion of a spherical shell in a viscous liquid. © 2012 Allerton Press, Inc